A5045186424- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- PARP inhibition in cancer therapy
- Neuroendocrine Tumor Research Advances
- Sirtuins and Resveratrol in Medicine
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- CAR-T cell therapy research
- Wnt/β-catenin signaling in development and cancer
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Tannin, Tannase and Anticancer Activities
- Galectins and Cancer Biology
- Immunotherapy and Immune Responses
- Adenosine and Purinergic Signaling
- Adipose Tissue and Metabolism
- Bone and Dental Protein Studies
- Calcium signaling and nucleotide metabolism
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Toxin Mechanisms and Immunotoxins
- Genomics, phytochemicals, and oxidative stress
- Cancer Mechanisms and Therapy
- Barrier Structure and Function Studies
The University of Texas MD Anderson Cancer Center
2024
The University of Texas Health Science Center at Houston
2023-2024
Beni-Suef University
2015-2023
Jeonbuk National University
2018-2023
Chonbuk National University Hospital
2017-2022
Renal Research Institute
2022
Weatherford College
2020-2021
National University
2021
Hongik University
2020-2021
King Salman International University
2021
Central nervous system cytotoxicity is linked to neurodegenerative disorders. The objective of the study was investigate whether monosodium glutamate (MSG) neurotoxicity can be reversed by natural products, such as ginger or propolis, in male rats. Four different groups Wistar rats were utilized study. Group A served a normal control, whereas group B orally administered with MSG (100 mg/kg body weight, via oral gavage). Two additional groups, C and D, given along dose (500 weight) either...
PARP1 facilitates the recovery of DNA-damaged cells by recruiting DNA damage response molecules such as γH2AX and BRCA1/2, plays a role in resistance to antitumor therapies. Therefore, PARP inhibition being evaluated an anti-cancer therapy. However, there are limited studies regrading osteosarcoma.We expression 35 human osteosarcomas investigated effects co-treatment inhibitor, olaparib, doxorubicin osteosarcoma cells.The patterns PARP1, γH2AX, BRCA1, BRCA2 were significantly associated with...
SMARCA4 encodes one of two mutually exclusive ATPase subunits in the BRG/BRM associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive chromatin accessibility and transcriptional activation. among most recurrently mutated genes human cancer, including ∼30% germinal center (GC)-derived Burkitt lymphomas. In mice, GC-specific Smarca4 haploinsufficiency cooperated with MYC over-expression lymphomagenesis. Furthermore, monoallelic deletion drove GC hyperplasia...
The long non-coding RNA H19 suppresses carcinogenesis and chemoresistance in hepatocellular carcinoma – (lncRNA) represents a maternally expressed epigenetically regulated imprinted gene product is discussed to have either tumor-promoting or tumor-suppressive actions. Recently, was shown be under inflammatory conditions. Therefore, aim of this study determine the function (HCC), an inflammation-associated type tumor. In four different human HCC patient cohorts distinctly downregulated tumor...
Hepatocellular carcinoma (HCC) is one of the common cancers and lethal diseases worldwide. Both oxidative stress chronic inflammation contribute to pathogenesis HCC. Because limited treatment options a grave prognosis HCC, preventive management has been emphasized. The marine macroalgae Ulva lactuca (Ulvaceae) consumed by humans livestock because its nutritional value. Recent studies showed that various extracts U. possess antiviral, antiplasmodial, antinephrotoxic, antioxidant,...
FAM83H was initially identified as a protein essential for dental enamel formation. Recent reports have shown that is also involved in the progression of human cancers conjunction with tumor-associated molecules, such MYC and β-catenin. However, role sarcoma has not yet been investigated.The expression roles β-catenin were evaluated osteosarcomas from 34 patients osteosarcoma cells.The nuclear FAM83H, cytoplasmic significantly associated each other shorter survival by univariate analysis. In...
// Kaushlendra Tripathi 1, * , Usama K. Hussein 2, Roja Anupalli 3, Reagan Barnett 1 Lavanya Bachaboina Jennifer Scalici Rodney P. Rocconi Laurie B. Owen Gary A. Piazza Komaraiah Palle Department of Oncologic Sciences, Mitchell Cancer Institute, University South Alabama, Mobile, USA 2 Faculty Science, Beni Suef University, Suef, Egypt 3 Genetics, Osmania Hyderabad, India These authors have contributed equally to this work Correspondence to: Palle, e-mail: kpalle@health.southalabama.edu...
SIRT6 is involved in various cellular signaling pathways including those tumorigenesis association with β-catenin. However, the role of has been controversially reported and studies on ovarian cancers limited. In this study, we evaluated expression roles conjunction active β-catenin 104 human carcinomas cancer cells. carcinomas, expressions were associated higher tumor stage, histologic grade, platinum-resistance. Moreover, nuclear (104 carcinomas; P = 0.010, 63 high-grade serous 0.040)...
Diabetes Mellitus is a chronic generalized disorder due to insulin insufficiency or resistance. Skeletal muscles represent one of the most important target organs that affected by signaling. The aim current work was investigate effect metformin versus vitamin D (and also simultaneous administration) therapy in type 2 diabetic (T2D) rats on state muscle and sensitivity. Thirty six male constituted animal model have been divided into five groups: control, Diabetic, Diabetic + Metformin,...
Background/Aims: Hepatocellular carcinoma (HCC) represents the second most common cause of cancer-related deaths worldwide, not least due to its high chemoresistance.The long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1), localised in paraspeckles, has been shown enhance chemoresistance several cancer types.Since data on NEAT1 HCC chemosensitivity are completely lacking and is linked poor prognosis, we aimed study expression link prognosis.Methods: was determined either...
FAM83H is primarily known for its role in amelogenesis; however, recent reports suggest might be involved tumorigenesis. Although the studies of kidney cancer are limited, a search public database shows significant association between and pannexin-2 (PANX2) clear cell renal carcinomas (CCRCCs). Therefore, we evaluated clinicopathological significance immunohistochemical expression PANX2 199 CCRCC patients. The were significantly associated with each other. In univariate analysis, individual...
Lung cancer is the primary cause of cancer-related death worldwide, and development novel lung preventive therapeutic agents are urgently needed. Brassica nigra (black mustard) seeds commonly consumed in several Asian African countries. Mustard previously exhibited significant anticancer activities against types. In present study, we have investigated various cellular molecular mechanisms effects an ethanolic extract B. A549 H1299 human non-small cell lines. showed a substantial...
Abstract Background SIRT6 has diverse roles in cells, and the role of tumorigenesis is controversial. Considering as an inducer DNA damage repair, it might be involved resistance to anti-cancer therapy. Methods We evaluated prognostic significance 37 osteosarcomas investigated therapeutic efficacy on anticancer effects doxorubicin, olaparib, ATM inhibitor. Results Immunohistochemical expression was significantly associated with shorter overall survival relapse-free osteosarcoma patients,...
FAM83H primarily is known for its function in tooth development.Recently, a role tumorigenesis, conjunction with MYC and β-catenin, has been suggested.Analysis of public data indicates that expression closely associated SCRIB human gastric cancers.Therefore, this study investigated the roles 200 cancers cancer cells.In carcinomas, both individual combined patterns nuclear were independent indicators shorter survival carcinoma patients.In MKN-45 NCI-N87 cells, proliferation invasiveness...
Poncirus fructus (PF) is a phytochemical compound extracted from the dry, immature fruits of trifoliate. PF traditionally used to treat gastrointestinal disorders, allergies, and inflammatory disease. In East Asia, also known for its anticancer properties. There are numerous reports on anti‑inflammatory effects in wide range cancers diseases, respectively. However, role inducing apoptosis suppressing invasiveness hepatocellular carcinoma (HCC) remains unclear. This study investigated ability...
Immunoprevention is an emerging consideration for solid tumors, including pancreatic ductal adenocarcinoma (PDAC). We and others have shown that Kras mutations in genetic models of spontaneous intraepithelial neoplasia (PanIN), which a precursor to PDAC, results CD73 expression the neoplastic epithelium some populations infiltrating immune cells, macrophages CD8 T cells. ecto-enzyme converts extracellular adenosine monophosphate adenosine, critical inhibitory molecule PDAC. hypothesized...
Journal Article Caveolin‐1 is expressed on multipotent cells of hair follicles and might be involved in their resistance to chemotherapy Get access S. Selleri, Selleri Department Human Morphology Institute Pathology, National Cancer Institute, Università degli Studi di Milano, Via Mangiagalli, 31, 20133 Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar F. Arnaboldi, Arnaboldi M. Palazzo, Palazzo U. Hussein, Hussein A. Balsari, Balsari C. Rumio Cristiano...
SCRIB is a polarity protein important in maintaining cell junctions. However, recent reports have raised the possibility that might role human cancers. Thus, this study evaluated roles of ovarian In 102 carcinomas, nuclear expression predicted shorter survival carcinoma patients, especially patients who received post-operative chemotherapy. SKOV3 and SNU119 cancer cells, overexpression stimulated proliferation invasion cells. Knockout inhibited vivo tumor growth cells promoted growth....
CK2α/CSNK2A1 is involved in cancer progression by phosphorylating various signaling molecules. Considering the role of CSNK2A1 and phosphorylation SIRT6 chemoresistance through DNA damage repair pathway, might be resistance to conventional anti-cancer therapies. We evaluated expression phosphorylated 37 osteosarcoma patients investigated effects on Ser338 doxorubicin. Higher was associated with shorter survival patients. U2OS KHOS/NP cells induced overexpression were resistant cytotoxic...
Abstract Background Recently, FAM83H was reported to have roles in cancer progression conjunction with oncogenic molecules such as MYC and b-catenin. Moreover, the data from public database indicates a molecular relationship between zinc finger proteins, especially ZNF16. However, studies on ZNF16 gallbladder been limited. Methods This study investigated expression of 105 carcinomas. Results In human carcinomas, immunohistochemical significantly associated expression. univariate analysis,...
Gallbladder cancer is commonly associated with inflammation, which indicates that inflammation-related cytokines and cytokine receptors are related to the progression of gallbladder cancers. Interleukin 4 (IL4) a well-known promotes differentiation naive helper T cells (Th0) type 2 (Th2). IL13 secreted by Th2 cells. IL4 closely in immune responses. However, role IL4Rα IL13Rα1 signaling pathway has not been fully understood development cancer.In human carcinomas, expression were evaluated...
Oxidative stress induces various intracellular damage, which might be correlated with tumorigenesis. Accumulated oxidative stresses inactivate protein tyrosine phosphatase (PTP) by oxidizing it, and inducing the phosphorylation of H2AX (γH2AX) in response to DNA damage.We evaluated clinical significance expression oxidized-PTP γH2AX 169 gastric carcinomas.Immunohistochemical nuclear oxidized-PTP, cytoplasmic were significantly associated each other, their expressions predicted shorter...
Abstract Background IL4Rα and IL13Rα1 are constituents of the type II IL4 receptor. Recently, were reported to have roles in cancer progression suggested as potential prognostic markers. However, studies on soft-tissue sarcomas been limited. Methods This study investigated immunohistochemical expression 89 extremities, superficial trunk, retroperitoneum. Immunohistochemical staining for scored according a combination intensity area tissue microarray samples. Positivity determined using...