A5001872808- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Bone Tissue Engineering Materials
- Eosinophilic Disorders and Syndromes
- Immune Response and Inflammation
- Histone Deacetylase Inhibitors Research
- Immunotherapy and Immune Responses
- Cutaneous lymphoproliferative disorders research
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Antimicrobial Peptides and Activities
- Cellular transport and secretion
- RNA Interference and Gene Delivery
- Luminescence and Fluorescent Materials
- Ferrocene Chemistry and Applications
- Advancements in Semiconductor Devices and Circuit Design
- Titanium Alloys Microstructure and Properties
- Monoclonal and Polyclonal Antibodies Research
- Advanced Drug Delivery Systems
The University of Texas MD Anderson Cancer Center
2022-2024
Nanyang Technological University
2016-2022
Indian Institute of Technology Bombay
2021
A new drug concentration meter is developed. In vivo release can be monitored precisely via a self-indicating delivery system consisting of aggregation-induced emission thermoresponsive hydrogel. By taking the advantage system, one easily detect depletion drugs, and reinject to maintain dosage in optimal therapeutic window. As service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may re-organized for online delivery,...
SMARCA4 encodes one of two mutually exclusive ATPase subunits in the BRG/BRM associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive chromatin accessibility and transcriptional activation. among most recurrently mutated genes human cancer, including ∼30% germinal center (GC)-derived Burkitt lymphomas. In mice, GC-specific Smarca4 haploinsufficiency cooperated with MYC over-expression lymphomagenesis. Furthermore, monoallelic deletion drove GC hyperplasia...
Abstract In this study, we report that the integrin LFA-1 cross-linking with its ligand ICAM-1 in human PBMCs or CD4+ T cells promotes Th1 polarization by upregulating IFN-γ secretion and T-bet expression. stimulation PBMCs, cells, cell line HuT78 activates Notch pathway nuclear translocation of cleaved Notch1 intracellular domain (NICD) upregulation target molecules Hey1 Hes1. Blocking a neutralizing Ab specific inhibition γ-secretase inhibitor substantially inhibits LFA-1/ICAM-1–mediated...
Abstract Post-transcriptional gene silencing holds great promise in discovery research for addressing intricate biological questions and as therapeutics. While various approaches, such siRNA CRISPR-Cas9 techniques, are available, these cannot be effectively applied to “hard-to-transfect” primary T-lymphocytes. The locked nucleic acid-conjugated chimeric antisense oligonucleotide, called “GapmeR”, is an emerging new class of molecule. Here, we show that GapmeR internalizes into human T-cells...
Recent studies have described the remarkable clinical outcome of anti-CD19 chimeric antigen receptor (CAR) T cells in treating B-cell malignancies. However, over 50% patients develop life-threatening toxicities associated with cytokine release syndrome which may limit its utilization low-resource settings. To mitigate toxicity, we designed a novel humanized CAR by humanizing framework region single-chain variable fragment (scFv) derived from murine FMC63 mAb and combining it CD8α...
CG-NAP, also known as AKAP450, is a cytosolic scaffolding protein involved in the targeted positioning of multiple signaling molecules, which are critical for cellular functioning. Here, we show that CG-NAP predominantly expressed human primary T-lymphocytes, localizes close proximity (<0.2 μm) with centrosomal and Golgi structures serves docking platform Protein Kinase A (PKA). GapmeR-mediated knockdown inhibits LFA-1-induced T-cell migration impairs chemotaxis towards chemokine SDF-1α....
Background: Hesperetin is a natural compound known for its cholesterol-lowering effect and wide range of pharmacological activities. Objectives: Investigating the potential anticancer activities in malignant hematolymphoid cell lines HuT78 MJ, derived from patients with Cutaneous T-Cell Lymphomas (CTCL). Methods: The cytotoxic on two different CTCL lines, was assessed by MTS-based colorimetric assay. Apoptosis, cycle, ROS (Reactive Oxygen Species) molecular analysis were performed using...
Host defense peptides represent an important component of innate immunity. In this work, we report the anticancer properties a panel hyper-charged wholly cationic antimicrobial dodecapeptides (CAPs) containing multiple canonical forms lysine and arginine residues. These CAPs displayed excellent bactericidal activities against broad range pathogenic bacteria by dissipating cytoplasmic membrane potential. Specifically, identified two CAPs, named HC3 HC5, that effectively killed significant...
The development of new organometallic compounds as anticancer agents is currently an active area research. Here, we report the design, synthesis and characterization a panel 10 ferrocenyl-phosphine derivatives (FD1-FD10) analysis their anti-proliferative activities in hematolymphoid cells representing non-Hodgkin cutaneous T-cell lymphoma (CTCL). gold-coordinated complex FD10 exhibited significant dose-dependent cytotoxicity 4 different CTCL cell lines - HuT78, HH, MJ MyLa. concentrations...
In article number 1603404, Yun-Long Wu, Xian Jun Loh, and co-workers have created a self-indicating hydrogel that instantly reveals real-time drug concentration in the hydrogel. The gel shows potential as meter to benefit experimental non-invasive monitoring of actual release profile, which is not effectively supported by current technologies materials.
Abstract Non-Hodgkin’s lymphoma (NHL) is a diverse group of malignancies, encompassing the most common diffuse large B-cell (DLBCL) to rarer T-cell lymphomas. DDX3X an RNA helicase and, depending on tumour type, plays suppressive or oncogenic roles in cancer. However, its role NHL not clear. Targeted sequencing hotspots exons 8-15 cohort 158 unselected DLBCL subjects showed mutations 5 cases; whereas whole exome 9 relapsed/refractory patients treated with R-CHOP identified 4 cases. (n=223)...