A5103234064- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Cutaneous lymphoproliferative disorders research
- CAR-T cell therapy research
- Nutrition and Health in Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and disorders
- Cancer Immunotherapy and Biomarkers
- Clinical Nutrition and Gastroenterology
- Acute Lymphoblastic Leukemia research
- Diet and metabolism studies
- Cytokine Signaling Pathways and Interactions
- Apelin-related biomedical research
National Cancer Centre Singapore
2017-2020
National University of Singapore
2013-2016
Aberrant activation of the JAK3-STAT signaling pathway is a characteristic feature many hematological malignancies. In particular, hyperactivity this cascade has been observed in natural killer/T-cell lymphoma (NKTL) cases. Although first-in-class JAK3 inhibitor tofacitinib blocks activity NKTL both vitro and vivo, its clinical utilization cancer therapy limited by pan-JAK inhibition activity. To improve therapeutic efficacy NKTL, we have developed highly selective durable PRN371 that...
Summary Peripheral T‐cell lymphomas (PTCL) and natural killer (NK)/T‐cell (NKTCL) are a heterogeneous group of aggressive malignancies with dismal outcomes limited treatment options. While the phosphatidylinositol 3‐kinase (PIK3) pathway has been shown to be highly activated in many B‐cell lymphomas, its therapeutic relevance PTCL NKTCL remains unclear. The aim this study is investigate expression PIK3 phosphatase tensin homolog (PTEN) these subtypes lymphoma identify potential targets for...
Extranodal NK/T-cell lymphoma, nasal type (NKTL) is an aggressive of non-Hodgkin lymphoma closely associated with Epstein-Barr virus and characterized by varying degrees systemic inflammation. We aim to examine the prognostic significance peripheral blood neutrophil-lymphocyte ratio (NLR) in patients NKTL. Therefore, we conducted a retrospective review 178 biopsy-proven NKTL from National Cancer Centre Singapore Samsung Medical Center, South Korea. Using receiver operating curve analysis,...
Among Asian ethnic groups, Chinese or Malays are more insulin sensitive than South Asians, in particular lean individuals. We have further reported that body fat partitioning did not explain this difference sensitivity. examined whether adipocytokines might the differences relationship between obesity and resistance among three major groups Singapore. This was a cross-sectional study of 101 Chinese, 82 Malays, 81 men. Insulin sensitivity index (ISI) measured using hyperinsulinemic euglycemic...
7549 Background: Natural killer/T-cell lymphoma (NKTL) is a rare type of non-Hodgkin that occurs more frequently in East Asia and Latin America associated with Epstein–Barr virus infection. Recent whole-exome sequencing studies NKTL have reported recurrent somatic mutations genes JAK-STAT pathway, however the role aberrant signaling tumor immune escape through PD-L1 regulation unclear. Methods: To determine prevalence pathway alteration NKTL, we performed targeted 188 109 (22 Singapore...
Abstract: This study aims to identify recurrent genetic alterations in relapsed or refractory (RR) natural-killer/T-cell lymphoma (NKTL) patients who have achieved complete response (CR) with programmed cell death 1 (PD-1) blockade therapy. Seven of the eleven treated pembrolizumab CR while remaining four had progressive disease (PD). Using whole genome sequencing (WGS), we found clonal structural rearrangements (SR) PD-L1 gene seven (57%) patients’ pretreated tumors. These SRs consist...
Introduction: Natural killer/T-cell lymphoma (NKTL) is a rare type of non-Hodgkin that occurs more frequently in East Asia and Latin America associated with Epstein–Barr virus infection. Recent whole-exome sequencing studies NKTL have reported recurrent somatic mutations genes JAK-STAT pathway. We sought to determine the contribution aberrant signalling PD-L1 mediated immune checkpoint evasion NKTL. Methods: To prevalence pathway alteration NKTL, we performed targeted 188 110 (22 Singapore...