About
Contact & Profiles
A5102941634
Research Areas
- Cytokine Signaling Pathways and Interactions
- Hair Growth and Disorders
- Immune Cell Function and Interaction
- interferon and immune responses
- NF-κB Signaling Pathways
- Wnt/β-catenin signaling in development and cancer
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
Zhejiang Chinese Medical University
2024
National Cancer Centre Singapore
2018
10.1016/j.jep.2024.118227
article
EN
Journal of Ethnopharmacology
2024-04-28
Aberrant activation of the JAK3-STAT signaling pathway is a characteristic feature many hematological malignancies. In particular, hyperactivity this cascade has been observed in natural killer/T-cell lymphoma (NKTL) cases. Although first-in-class JAK3 inhibitor tofacitinib blocks activity NKTL both vitro and vivo, its clinical utilization cancer therapy limited by pan-JAK inhibition activity. To improve therapeutic efficacy NKTL, we have developed highly selective durable PRN371 that...
10.1038/s41375-017-0004-x
article
EN
cc-by-nc-nd
Leukemia
2018-02-02
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