A5009336240- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Protein Degradation and Inhibitors
- Acute Myeloid Leukemia Research
- Cancer Treatment and Pharmacology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Cutaneous lymphoproliferative disorders research
- 14-3-3 protein interactions
- Histone Deacetylase Inhibitors Research
- CAR-T cell therapy research
- T-cell and Retrovirus Studies
- Hepatitis B Virus Studies
- Chronic Myeloid Leukemia Treatments
- CNS Lymphoma Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- Radiomics and Machine Learning in Medical Imaging
- Venous Thromboembolism Diagnosis and Management
Mount Elizabeth Novena Hospital
2022-2025
University of Malaya
2018-2025
Singapore General Hospital
2013-2024
Ho Chi Minh University of Banking
2024
Harbin Institute of Technology
2024
Mount Elizabeth Hospital
2021-2024
Gleneagles Hospital
2024
Tan Tock Seng Hospital
2024
National University of Singapore
2024
National University of Malaysia
2023
The molecular pathogenesis of natural killer/T-cell lymphoma (NKTCL) is not well understood. We conducted whole-exome sequencing and identified Janus kinase 3 (JAK3) somatic-activating mutations (A572V A573V) in 2 4 patients with NKTCLs. Further validation the prevalence JAK3 was determined by Sanger high-resolution melt (HRM) analysis an additional 61 cases. In total, 23 65 (35.4%) cases harbored mutations. Functional characterization support its involvement cytokine-independent JAK/STAT...
The incidence of multiple myeloma (MM) is known to be variable according ethnicity. However, the differences in clinical characteristics between ethnic groups are not well‐defined. In Asian countries, although MM has been lower than that Western there growing evidence increasing rapidly. Myeloma Network decided initiate first multinational project describe and practices Asia. Data were retrospectively collected from 23 centers 7 countries regions. at diagnosis, survival rates initial...
Although combination therapy is the standard of care for relapsed/refractory non-Hodgkin's lymphoma (RR-NHL), treatment chosen an individual patient empirical, and response rates remain poor in individuals with chemotherapy-resistant disease. Here, we evaluate experimental-analytic method, quadratic phenotypic optimization platform (QPOP), prediction patient-specific drug efficacy from a limited quantity biopsied tumor samples. In this prospective study, enrolled 71 patients RR-NHL (39 B...
Primary mediastinal large B-cell lymphoma (PMBCL) is a distinct clinico-pathological subtype of diffuse with unclear prognostic factors and limited clinical data. Optimal treatment role for radiotherapy not fully defined. We performed multicenter retrospective review 124 patients newly diagnosed PMBCL between 2001 2016. Treatment regimens were R-CHOP (n = 41), + RT 37), DA-EPOCH-R 46). 6% 3) in the group received RT. With median follow up 45 months, overall 5-year OS PFS was 89.4% 82.4%,...
Abstract In the paper, an FBG-based biaxial extensometer is presented to detect ground movement, which a crucial element in slope monitoring systems. Multiple FBGs were used as displacement sensors establish sensing nodes at various locations along HDPE pipe. Each node comprises two for measurement. A numerical model based on characterization matrix equation formulated estimate lateral vectors using data obtained from all FBG sensors. The inclusion of torsion effects characteristic addresses...
Abstract PURPOSE: Functional precision medicine aims to expand the landscape of effective drug treatment options beyond standard care through additional insights from ex vivo phenotypic response data. In our previous work, we have demonstrated clinical feasibility Optim.AI™, a combinatorial functional platform, in identifying and resistant for non-Hodgkin lymphoma acute myeloid leukemia (AML). This study further investigates utility concordance Optim.AI™ predicting sensitivity or resistance...