A5009864755- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- CNS Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Pulmonary Hypertension Research and Treatments
- Erythropoietin and Anemia Treatment
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Blood groups and transfusion
- Viral-associated cancers and disorders
- Transplantation: Methods and Outcomes
- Neutropenia and Cancer Infections
- Hematological disorders and diagnostics
- Blood disorders and treatments
- Protein Degradation and Inhibitors
- Liver Disease and Transplantation
- HIV/AIDS drug development and treatment
- Cutaneous lymphoproliferative disorders research
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
Ramathibodi Hospital
2016-2025
Mahidol University
2015-2024
Chiang Mai University
2021
Palmetto Hematology Oncology
2013
Vanderbilt University
1993
Abstract Purpose: To examine the reproducibility of single breathhold T2* technique from different scanners, after installation standard methodology in five international centers. Materials and Methods: Up to 10 patients each center were scanned twice locally for local interstudy heart liver T2*, then flown a central MR facility be rescanned on reference scanner intercenter reproducibility. Interobserver all scans was also assessed. Results: Of 49 scanned, 5.9% 5.8% liver. Local 7.4% 4.6%...
Abstract Randomized clinical trials have shown ixazomib, lenalidomide and dexamethasone (IRd) to be efficacious safe in Asian patients with relapsed/refractory multiple myeloma (RRMM); however, real-world data are limited. The APEX study was a multicenter, observational cohort of IRd conducted at 16 sites across South Korea, Malaysia, Thailand. Overall, 104 treated during 2016–2023 were enrolled; collected by retrospective chart review 6-month prospective follow-up. Median age initiation...
Abstract β‐Thalassemia intermediate patients show a remarkable clinical heterogeneity. We examined the phenotypic diversity of 950 β‐thalassemia/Hb E in an attempt to construct system for classifying disease severity. A novel scoring based on six independent parameters, hemoglobin level, age at presentation, receiving first blood transfusion, requirement spleen size, and growth development, was able separate into three distinctive severity categories: mild, moderate, severe courses. This...
Summary. Small pulmonary arterial thromboses can occur following splenectomy of patients with haemoglobin E/β‐thalassaemia (Hb E/β‐thal). We compared plasma markers coagulation activation in vivo and red blood cell (RBC) procoagulant activity 15 Hb E/β‐thal who were not splenectomized (NS), had been (S), normal controls (NC). Levels thrombin–antithrombin III complex (TAT) significantly higher the S group than either NS or NC groups, levels prothrombin fragment 1.2 (F 1.2) group. Diluted...
Patients with non-transfusion-dependent thalassemia (NTDT) often develop iron overload that requires chelation to levels below the threshold associated complications. This can take several years in patients high burden, highlighting value of long-term data. Here, we report 1-year extension THALASSA trial assessing deferasirox NTDT; continued or crossed from placebo deferasirox. Of 133 entering extension, 130 completed. Liver concentration (LIC) decrease over 2 years; mean change was -7.14 mg...
We investigated the effects of a low n-6 fatty acid (FA) diet supplemented with fish oil on serum pro-inflammatory cytokine concentrations and clinical variables in patients active rheumatoid arthritis (RA). Sixty were randomly assigned to receive FAs n-3 supplement (fish group), placebo (placebo or no special intervention (control group). Serum cytokines biochemical evaluated at baseline various timepoints. At week 18 group had significant reductions linoleic acid, C-reactive protein (CRP)...
Summary Liver iron concentration ( LIC ) assessment by magnetic resonance imaging MRI remains the gold standard to diagnose overload and guide chelation therapy in patients with non‐transfusion‐dependent thalassaemia NTDT ). However, limited access technology expertise worldwide makes it practical also use serum ferritin assessments. The THALASSA (assessment of Exjade ® THALASS emiA patients) study assessed efficacy safety deferasirox iron‐overloaded provided a large data set allow...
Abstract The aim of this study was to assess the outcome patients with aplastic anemia (AA), receiving rabbit anti‐thymocyte globulin (Thymoglobulin, SANOFI) and cyclosporin, as first line treatment. Eligible were 955 AA, treated Thymoglobulin, between 2001 2008 ( n = 492), or 2009 2012 463). median age 21 years (range 1‐84). Mortality within 90 days 5.7% 2.4%, respectively in two time periods P .007).The actuarial 10‐year survival for entire population 70%; transplant free 64%. Predictors...
Disease-related complications and management are different among patients with thalassemia. This study was aimed to review the prevalence, clinical risk factors for in thalassemia Thailand. A multicenter cross-sectional conducted aged ≥ 18 years old. Thalassemia-related were reviewed. The parameters significantly associated analyzed by logistic regression methods. prevalence of thalassemia-related 100% transfusion-dependent (TDT) 58.8% non-transfusion-dependent (NTDT). Advanced age...
The effect of parenteral glutamine dipeptide (Gln) supplementation on neutrophil phagocytosis, superoxide anion generation (SAG), prevention chemotherapy-induced side-effects and cost-effectiveness was examined in a pilot study acute myeloid leukaemia (AML) patients receiving chemotherapy. Sixteen AML were randomized to receive intravenous with Gln (30 g/day) or an equivalent quantity (25 standard amino acid mixture (control) days 1 − 5 Complete blood count evaluated twice week until...
Abstract Systemic reports on the descriptive epidemiology of non‐Hodgkin lymphoma (NHL) from Southeast Asia are scarce. A nationwide multi‐institutional registry was conducted to compare histopathology, clinical features, and survival Thai adult patients with NHL using large registries, especially those Far East (FEA). Using a web‐based system, 13 major medical centers 4 geographic regions Thailand prospectively collected, 2007 2014, diagnostic pathology, according World Health Organization...
Standard treatment with a thiotepa-based regimen in countries limited resource is less feasible. Aims of the study were to evaluate outcome, and identify prognostic factors patients primary central nervous system lymphoma (PCNSL). We conducted retrospective 43 diagnosed PCNSL, DLBCL subtype, who treated either HDMTX-based regimen, whole brain radiotherapy (WBRT), or both between 2010 2017. There median age 65 years (range 34–89 years). Protein expression CD10, Bcl6, MUM1, Bcl2 MYC found 19,...
Thalidomide based regimen is an effective and well tolerated therapy in multiple myeloma (MM) patients, however, there were a small number of studies written about the results thalidomide non-transplant MM patients. We therefore conducted retrospective study 42 consecutive patients with newly diagnosed relapsed/refractory treated thalidomide- induction regimens followed by maintenance therapy.Induction dexamethasone, oral combination melphalan, prednisolone administrated 22 16 respectively....
Increased frequency of thrombosis has been observed in patients with hemoglobin E/beta-thalassemia (Hb E/beta-thal) disease, particularly those who have previously splenectomized. We compared various hemostatic and thrombotic markers blood from 15 Hb E/beta-thal were not splenectomized (NS), had (S), normal controls (NC). Levels plasma thrombin-antithrombin, beta2 thromboglobulin, C-reactive protein, tissue plasminogen activator antigen significantly higher the S group than either NS or NC...
The relationship between asplenia and thrombophilia in β-thalassemia disease patients is not yet completely understood. One hundred ten adult hemoglobin (Hb) E/β-thalassemia (E/β-Thal) outpatients, dichotomized according to the presence or absence of spleen, were prospectively studied for evidence intravascular hemolysis (IVH) vascular endothelial cell (EC) activation. Biomarkers IVH (serum cell-free Hb), EC [soluble E-selectin (sE-selectin) soluble adhesion molecule 1 (sVCAM-1)], platelet...
Abstract Bone marrow transplantation is the only therapeutic option that can potentially eliminate thalassemic disease. Early results indicated children in Class 3 Lucarelli had a much worse outcome because of high nonrejection mortality and rejection rate. In present study, reduced intensity stem cell (RIT) was performed eight patients conditioned by busulfan, fludarabine, antilymphpcute globulin. One additionally received thiotepa, total lymphoid irradiation (TLI), while one TLI. All...
Summary Some patients with relapsed/refractory Hodgkin lymphoma ( HL ) are not considered suitable for stem cell transplant SCT and have a poor prognosis. This phase IV study (NCT01990534) evaluated brentuximab vedotin (1·8 mg/kg intravenously once every 3 weeks) in 60 (aged ≥18 years) CD30‐positive , history of ≥1 prior systemic chemotherapy regimen, who were unsuitable /multi‐agent chemotherapy. Primary endpoint was overall response rate ORR per independent review facility IRF ). Secondary...
Osteoporosis is a common problem in thalassemics. As the most affected bone spinal vertebrae, theoretically, it should have greatest risk of fracture. However, vertebral fracture (VF) thalassemics was rarely reported. Screening for asymptomatic VF has not been We, therefore, evaluated prevalence adolescents and young adults with thalassemia. A total 150 patients thalassemia, aged 10 years older were enrolled. Lateral thoracolumbar spine radiography evaluated. Twenty (13%) had 6 20 (30%)...