A5066097592- Lymphoma Diagnosis and Treatment
- 14-3-3 protein interactions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Cell Function and Interaction
- Burkholderia infections and melioidosis
- Chemical Looping and Thermochemical Processes
- Pneumonia and Respiratory Infections
- DNA Repair Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Health disparities and outcomes
- Respiratory viral infections research
- Carcinogens and Genotoxicity Assessment
- Colorectal and Anal Carcinomas
- T-cell and Retrovirus Studies
- Brucella: diagnosis, epidemiology, treatment
- Migration, Aging, and Tourism Studies
- Immunodeficiency and Autoimmune Disorders
- Effects of Radiation Exposure
- Dementia and Cognitive Impairment Research
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
Republic Polytechnic
2015
National Cancer Centre Singapore
2008-2013
Genome Institute of Singapore
2012
Singapore General Hospital
2007-2012
Duke-NUS Medical School
2012
National University of Singapore
2006
The molecular pathogenesis of natural killer/T-cell lymphoma (NKTCL) is not well understood. We conducted whole-exome sequencing and identified Janus kinase 3 (JAK3) somatic-activating mutations (A572V A573V) in 2 4 patients with NKTCLs. Further validation the prevalence JAK3 was determined by Sanger high-resolution melt (HRM) analysis an additional 61 cases. In total, 23 65 (35.4%) cases harbored mutations. Functional characterization support its involvement cytokine-independent JAK/STAT...
ABSTRACT Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with protean clinical manifestations. The major route infection thought to be through subcutaneous inoculation contaminated soil and water, although ingestion inhalation aerosols are also possible. This study examines intranasal in a murine model mimic inhalation. Two strains mice, C57BL/6 BALB/c, exhibit differential susceptibilities infection, mice being considerably more resistant. To examine...
Burkholderia pseudomallei is the causative agent for melioidosis. For many bacterial infections, cytokine dysregulation one of contributing factors to severe clinical outcomes in susceptible hosts. The C57BL/6 and BALB/c mice have been established as a differential model susceptibility murine In this study, we compared innate IFN-γ response B. between splenocytes characterized hyperproduction relatively vitro. Naïve were found produce more live infection splenocytes. Natural killer cells be...
Streptococcus pneumonia (the pneumococcus) is the leading vaccine preventable cause of serious infections in infants under 5 years age. The major correlate protection for pneumococcal serotype-specific IgG antibody. More recently, antibody-independent mechanisms have also been identified. Preclinical studies found that IL-17 secreting CD4+ Th17 cells reducing colonisation. This study assessed IL-17A levels children from Fiji with high and low carriage density, as measured by quantitative...
<p>PDF file - 185K, Representative HRM curves of a NKTCL case confirmed as heterozygous JAK3A573V mutation</p>
<p>PDF file - 185K, Representative HRM curves of a NKTCL case confirmed as heterozygous JAK3A573V mutation</p>
<div>Abstract<p>The molecular pathogenesis of natural killer/T-cell lymphoma (NKTCL) is not well understood. We conducted whole-exome sequencing and identified <i>Janus kinase 3</i> (<i>JAK3</i>) somatic–activating mutations (A572V A573V) in 2 4 patients with NKTCLs. Further validation the prevalence <i>JAK3</i> was determined by Sanger high-resolution melt (HRM) analysis an additional 61 cases. In total, 23 65 (35.4%) cases harbored mutations....
<div>Abstract<p>The molecular pathogenesis of natural killer/T-cell lymphoma (NKTCL) is not well understood. We conducted whole-exome sequencing and identified <i>Janus kinase 3</i> (<i>JAK3</i>) somatic–activating mutations (A572V A573V) in 2 4 patients with NKTCLs. Further validation the prevalence <i>JAK3</i> was determined by Sanger high-resolution melt (HRM) analysis an additional 61 cases. In total, 23 65 (35.4%) cases harbored mutations....