A5040552120- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Acute Lymphoblastic Leukemia research
- Histiocytic Disorders and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Parvovirus B19 Infection Studies
- CAR-T cell therapy research
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- HIV/AIDS drug development and treatment
- Hematopoietic Stem Cell Transplantation
- Genetic and rare skin diseases.
- Genital Health and Disease
- T-cell and Retrovirus Studies
- Renal and related cancers
- HIV/AIDS Research and Interventions
- Advanced Causal Inference Techniques
- Family Support in Illness
- Infectious Diseases and Mycology
- RNA modifications and cancer
- Immunodeficiency and Autoimmune Disorders
- Chromatin Remodeling and Cancer
Baylor College of Medicine
2016-2025
Children's Cancer Center
2017-2024
Texas Children's Hospital
2016-2024
New York Medical College
2014-2019
Kamuzu Central Hospital
2013-2017
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
2017
Ministry of Health
2017
University of Liverpool
2017
Dignitas International
2017
University of Malawi
2017
SMARCA4 encodes one of two mutually exclusive ATPase subunits in the BRG/BRM associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive chromatin accessibility and transcriptional activation. among most recurrently mutated genes human cancer, including ∼30% germinal center (GC)-derived Burkitt lymphomas. In mice, GC-specific Smarca4 haploinsufficiency cooperated with MYC over-expression lymphomagenesis. Furthermore, monoallelic deletion drove GC hyperplasia...
Abstract Long-term cure of childhood Burkitt lymphoma (BL) in sub-Saharan Africa after treatment with single-agent cyclophosphamide has been documented for more than half a century. Contemporary rates the highest-risk patients BL high-income countries exceed 90% using intensive multiagent chemotherapy. By contrast, majority African children still die. Data spanning 5 decades have repeatedly shown that most likely to achieve limited regimens are those lower-stage disease isolated jaw....
Abstract Background Kaposi sarcoma (KS) is the most common HIV‐associated malignancy in sub‐Saharan Africa. The presentation and outcomes of pediatric KS are not well understood. Procedure We performed a retrospective cohort analysis 81 HIV‐infected children with at Baylor Children's Clinical Centres Excellence Malawi Botswana from March 2003 to October 2009. Results Eighty‐one were identified whose median age was 8.0 (inter‐quartile range 5.1–11.3) years. lesions presented primarily on skin...
Point-of-care tools are needed in sub-Saharan Africa (SSA) to improve pediatric Burkitt lymphoma (BL) diagnosis and treatment. We evaluated plasma Epstein–Barr virus (pEBV) DNA as a BL biomarker Malawi. Prospectively enrolled children with were compared classical Hodgkin (cHL) nonlymphoma diagnoses. Pediatric patients received standardized chemotherapy supportive care. pEBV was measured at baseline, mid-treatment, treatment completion. Of 121 assessed children, detected 76/88 (86%) BL, 16/17...
Abstract Background Contemporary descriptions of classical Hodgkin lymphoma (cHL) are lacking from sub‐Saharan Africa where human immunodeficiency virus (HIV) and Epstein–Barr (EBV) prevalent. Methods We describe a prospective cHL cohort in Malawi enrolled 2013 to 2015. Patients received standardized treatment evaluation, including HIV status EBV testing tumors plasma. Results Among 31 patients with confirmed cHL, the median age was 19 years (range, 2–51 years) 22 (71%) were male. Sixteen...
PURPOSE Excellent survival for advanced (stages II with high lactate dehydrogenase, III, and IV) pediatric mature B-cell non-Hodgkin lymphoma (MB-NHL) has been achieved intensive regimens, but adoption in sub-Saharan Africa is limited by inadequate supportive care. We provide real-world data on treating MB-NHL high-dose methotrexate (HD-MTX; ≥1,000 mg/m 2 /cycle) where real-time serum MTX monitoring unavailable. METHODS identified two cohorts—a retrospective (January 2017-December 2020)...
Burkitt lymphoma (BL) is the most common paediatric cancer in sub-Saharan Africa (SSA). Anthracyline-based treatment standard resource-rich settings, but has not been described SSA. Children ≤18 years of age with newly diagnosed BL were prospectively enrolled from June 2013 to May 2015 Malawi. Staging and supportive care standardized, as was CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) for six cycles. Among 73 children BL, median 9·2 (interquartile range 7·7-11·8), 48 (66%)...
Kaposi sarcoma (KS) is the most common HIV-associated malignancy in children and adolescents Africa. Pediatric KS distinct from adult disease. We evaluated clinical characteristics associated with long-term outcomes. performed a retrospective observational analysis of 70 HIV-infected less than 18 years age diagnosed between 8/2010 6/2013 Lilongwe, Malawi. Local first-line treatment included bleomycin vincristine plus nevirapine-based highly active anti-retroviral therapy (HAART). Median was...
Abstract Langerhans cell histiocytosis (LCH) is a myeloid neoplastic disorder characterized by lesions with CD1a‐positive/Langerin (CD207)‐positive histiocytes and inflammatory infiltrate that can cause local tissue damage systemic inflammation. Clinical presentations range from single minimal impact to life‐threatening disseminated disease. Therapy for LCH has been established through serial trials empirically testing different chemotherapy agents durations of therapy. However, fewer than...
Background. Although Burkitt lymphoma (BL) is the most common childhood in sub-Saharan Africa, Hodgkin (HL) and other non-Hodgkin lymphomas occur. Diagnosing non-jaw mass presentations challenging with limited pathology resources. Procedure. We retrospectively analyzed 114 pediatric Lilongwe, Malawi, from December 2011 to June 2013 compared clinical versus pathology-based diagnoses over two time periods. Access resources became more consistent 2011-2012; interpretations were based on...
Abstract Background Systemic forms of EBV‐associated T‐cell lymphoproliferative disorders childhood (S‐EBV‐T‐LPD) comprise three major forms: EBV‐positive hemophagocytic lymphohistiocytosis (EBV‐HLH), systemic lymphoma (S‐EBV‐TCL), and chronic active EBV infection (S‐CAEBV). These occur rarely in children Western countries. Here, we described eight such entities. Design Eight cases (six clinical two autopsy) with S‐EBV‐T‐LPD were retrospectively identified from 1990 to 2015....
Abstract Pediatric non‐Hodgkin lymphoma (NHL) includes over 30 histologies (many with subtypes), approximately 800 cases per year in the United States. Improvements survival NHL past 5 decades align overall success of cooperative trial model dramatic improvements outcomes. As an example, for advanced Burkitt is now >95%. Major remaining challenges include relapsed and refractory disease long‐term morbidity survivors. Langerhans cell histiocytosis (LCH) was added to Committee portfolio...
Summary Adenovirus infection is a significant complication in paediatric AlloSCT recipients with mortality rate for disseminated adenovirus that may exceed 80%. We sought to determine the incidence, risk factors, and associated outcomes of 123 consecutive recipients. was diagnosed by antigen detection or viral culture, defined isolation virus presence correlating clinical symptoms. The probability developing 12·3% (CI 95 6·0–18·6). There were no statistically differences univariate analysis...
BACKGROUNDKaposi sarcoma (KS) is among the most common childhood cancers in Eastern and Central Africa. Pediatric KS has a distinctive clinical presentation compared with adult KS, which includes tendency for primary lymph node involvement, considerable proportion of patients lacking cutaneous lesions, potential fulminant disease. The molecular mechanisms or correlates these disease features are unknown.METHODSThis was cross-sectional study. All cases were confirmed by IHC KS-associated...
T- and natural killer (NK)-cell lymphomas are challenging childhood neoplasms. These cancers have varying presentations, vast molecular heterogeneity, several quite unusual in the West, creating diagnostic challenges. Over 20 distinct NK-cell neoplasms recognized by 2008 World Health Organization classification, demonstrating diversity potential complexity of these cases. In pediatric populations, selection optimal therapy poses an additional quandary, as most malignancies not been studied...