A5054223683- Acute Myeloid Leukemia Research
- Blood disorders and treatments
- Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Viral-associated cancers and disorders
- Immunodeficiency and Autoimmune Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Acute Lymphoblastic Leukemia research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Parvovirus B19 Infection Studies
- Sarcoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Hematopoietic Stem Cell Transplantation
- Glioma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Clinical Laboratory Practices and Quality Control
- Autoimmune and Inflammatory Disorders Research
- T-cell and Retrovirus Studies
- Chronic Myeloid Leukemia Treatments
- Cancer-related gene regulation
Texas Children's Hospital
2016-2025
Baylor College of Medicine
2016-2025
Children's Cancer Center
2017-2023
Dan L Duncan Comprehensive Cancer Center
2019
Institute of Forensic Sciences
2014
The University of Texas Health Science Center at Houston
2014
The University of Texas Medical Branch at Galveston
2000-2009
Division of Cancer Epidemiology and Genetics
2002-2003
Cancer Genetics (United States)
2003
Galveston College
2003
Immunoglobulin G4-related disease (IgG4-RD) is a systemic disorder characterized by multiorgan fibrosis with IgG4-producing plasma cells, increased IgG4 serum concentration, and responsiveness to steroid therapy. Involvement of the pancreas, salivary glands, orbit, aorta, other sites has been well documented in literature; however, there have limited reports cases involving coronary arteries. We report case 53-year-old Hispanic man who was brought emergency center diagnosed sudden cardiac...
Ethosuximide-associated aplastic anemia (AA) is a rare idiosyncratic disorder with unclear etiology. We report 17-year-old female absence seizures on ethosuximide, who was incidentally found to have pancytopenia and markedly hypocellular marrow (<5% cellularity) lupus erythematosus (LE) cells. The presence of antinuclear anti-histone antibodies supported diagnosis AA secondary drug-induced erythematosus. Ethosuximide discontinued, prednisone started marked blood count recovery. Our case...
Abstract Context.—Shwachman-Diamond syndrome (SDS) is a rare inherited disorder characterized by pancreatic insufficiency, neutropenia, and in some patients, metaphyseal dysostosis. Patients with SDS are at high risk for development of bone marrow failure, myelodysplastic syndrome, acute leukemia. The p53 gene plays major role cell-cycle regulation, particularly the presence genetic alteration DNA, critical step initiation leukemogenesis. up-regulation protein overexpression may occur as...
Abstract Context.—Shwachman-Diamond syndrome (SDS) is a rare inherited disorder characterized by pancreatic insufficiency, neutropenia, and in some patients, metaphyseal dysostosis. Patients with SDS are at high risk for development of bone marrow failure, myelodysplastic syndrome, acute leukemia. The p53 gene plays major role cell-cycle regulation, particularly the presence genetic alteration DNA, critical step initiation leukemogenesis. up-regulation protein overexpression may occur as...
Abstract Background Systemic forms of EBV‐associated T‐cell lymphoproliferative disorders childhood (S‐EBV‐T‐LPD) comprise three major forms: EBV‐positive hemophagocytic lymphohistiocytosis (EBV‐HLH), systemic lymphoma (S‐EBV‐TCL), and chronic active EBV infection (S‐CAEBV). These occur rarely in children Western countries. Here, we described eight such entities. Design Eight cases (six clinical two autopsy) with S‐EBV‐T‐LPD were retrospectively identified from 1990 to 2015....
The understanding of normal surface maturation pattern granulocytes plays an essential role in identifying abnormal patterns, which may be diagnostic or pathogenetic significance some disorders, such as myclodysplastic syndromes. CD24, is expressed only on and not monocytes, has been adequately studied. Surface marker studies eight control marrows indicate that CD24 bone marrow a similar to CD11b while much different than the more mature markers, CD16b CD35. Three sorting experiments show...
Abstract Flow cytometry studies of surface markers neutrophils have been performed mostly on peripheral blood, and for a limited spectrum diseases. Studying maturation defects developing in the bone marrow (BM) may be helpful BM diseases, such as myelodysplastic syndromes Shwachman‐Diamond syndrome. We applied an expanded panel antibodies to examine normal patterns 26 control samples together with microscopic correlation. Promyelocytes correlated well CD24 − CD11b populations, metamyelocytes...
Approximately 10% of children with primary myelodysplastic syndrome (MDS) have germ line GATA2 mutations, leading to the proposal that all MDS and certain cytogenetic findings, including monosomy 7, be tested for mutations regardless family history or other clinical features associated deficiency. In adults familial GATA2-MDS, those somatic in ASXL1 experience rapid disease progression acute myeloid leukemia (AML) poor prognosis after stem cell transplantation; however, prevalence pediatric...
Myeloid sarcoma (MS) is a neoplastic condition composed of immature myeloid cells involving an extramedullary site. We investigated underlying chromosomal and molecular alterations to assess potential markers prognosis outcome in this rare pediatric disease. conducted retrospective review clinicopathologic cytogenetic data from 33 patients with MS (ages 1 month–18 years) at our institution over 32 year period (1984–2016). Tissue-based cancer microarray targeted next-generation sequencing...