A5058316873- Acute Lymphoblastic Leukemia research
- Hemoglobinopathies and Related Disorders
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Viral-associated cancers and disorders
- Blood groups and transfusion
- Child Nutrition and Water Access
- Chronic Lymphocytic Leukemia Research
- Iron Metabolism and Disorders
- Global Cancer Incidence and Screening
- Neonatal and fetal brain pathology
- Cerebral Palsy and Movement Disorders
- Advanced Causal Inference Techniques
- T-cell and Retrovirus Studies
- Polyomavirus and related diseases
- Blood donation and transfusion practices
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hip and Femur Fractures
- Employment and Welfare Studies
- Phonocardiography and Auscultation Techniques
- Urban Transport and Accessibility
- ECG Monitoring and Analysis
- Infant Development and Preterm Care
- Family and Disability Support Research
- Malaria Research and Control
University of North Carolina at Chapel Hill
2016-2024
UNC Lineberger Comprehensive Cancer Center
2019-2024
University of Malawi
2016-2024
Children's Hospital of Philadelphia
2016-2021
University of North Carolina Health Care
2019
University of Botswana
2016-2017
University of Pennsylvania
2016
College of Charleston
1985
Burkitt lymphoma (BL) is the most common paediatric cancer in sub-Saharan Africa (SSA). Anthracyline-based treatment standard resource-rich settings, but has not been described SSA. Children ≤18 years of age with newly diagnosed BL were prospectively enrolled from June 2013 to May 2015 Malawi. Staging and supportive care standardized, as was CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) for six cycles. Among 73 children BL, median 9·2 (interquartile range 7·7-11·8), 48 (66%)...
Abstract Pediatric lymphoma is common in sub‐Saharan Africa, where survival estimates are often based on limited follow‐up with incomplete retention, introducing potential for bias. We compared and overall (OS) between passive active tracing within a prospective cohort of children Malawi. Median times were 4.4 months (interquartile range [IQR] 2.0–9.4) 10.8 (IQR 6.2–20.6) follow‐up, respectively. Twelve‐month was 69% (95% confidence interval [CI] 54–80) 44% CI 34–54) follow‐up. Passive...
Abstract Burkitt lymphoma (BL) is common in sub-Saharan Africa (SSA). In high-income countries, BL highly curable with chemotherapy. However, there are few prospective studies from SSA describing nonpediatric and no regional standard of care. Thirty-five participants age 15 years or older newly diagnosed were enrolled Malawi 2013 to 2018. Chemotherapy was administered according institutional guidelines, concurrent antiretroviral therapy if HIV infected. Median 21 (range, 15-61) (43%)...
Sickle cell disease (SCD) is among the most common inherited hematologic diseases in sub-Saharan Africa (SSA). Historically, hydroxyurea administration SSA has been restricted due to limited region-specific evidence for safety and efficacy.We conducted a prospective observational cohort study of pediatric patients with SCD Malawi. From January 2015 November 2017, at doses 10-20 mg/kg/day was administered children clinically severe (targeted use policy). December 2017 July 2018, prescribed...
The pathology laboratory at Kamuzu Central Hospital (KCH) in Lilongwe, Malawi was established 2011. We published our initial experiences development and telepathology 2013 2016, respectively. purpose of this paper is to provide an update on work by highlighting the positive role has played improving regional cancer care research. In addition, we a summary adult data from specimens received between July 1, 2011, May 31, 2019, with emphasis malignant diagnoses. compare these summaries...
Malnutrion among children with childhood cancer in low and middle income countries (LMICs) is prevelant. While national nutrition programs focus on under 5 years, can occur regardless of their age. Through a single-center retrospective cohort Lilongwe, Malawi, we aim to characterize the burden age-related malnutrition diagnosed evaluate them for any associations mortality. Four hundred sixty-three (63.5% ≥5 years 58.3% males) were identified.The majority (63.3%) malnourished; 23.1% had...
Esophageal squamous cell carcinoma (ESCC) is a major cause of cancer morbidity and mortality in Eastern Africa. The majority patients with ESCC Africa present advanced disease at the time diagnosis. Several palliative interventions for are currently use within region, including chemotherapy, radiation therapy without esophageal stenting self-expandable metallic stents; however, comparative effectiveness these low resource setting has yet to be examined. This prospective, observational,...
A safe and healthy natural built environment is fundamental to children’s health represents a significant determinant of community well-being. We aimed identify prioritize environmental concerns within resource-poor neighborhoods in the Dominican Republic using free-listing semi-structured focus groups composed parents caregivers perirural Consuelo, Republic. Transcripts were coded relevant themes identified qualitative content analysis. Demographic data information regarding trash disposal...
Background. Burnout during registrar training is high, especially in resource-limited settings where stressors are intensified. leads to decreased quality of life for doctors, poor job and patient satisfaction, difficulty retaining doctors. Objectives. Primary: measure burnout among registrars working at Princess Marina Hospital Gaborone, Botswana. Secondary: determine factors contributing identify potential wellness interventions. Methods. The validated Maslach Inventory was used the degree...
Background: Patient-reported outcomes (PROs) that assess health-related quality of life (HRQoL) are increasingly important components cancer care and research have been infrequently used in sub-Saharan Africa (SSA). We aimed to longitudinally measure HRQoL among pediatric lymphoma patients Malawi. Methods: administered the Chichewa Pediatric Patient-Reported Outcome Measurement Information System (PROMIS)-25 at diagnosis, active treatment, follow-up Lilongwe, Mean scores were calculated for...
PURPOSE Burkitt lymphoma (BL) accounts for 90% of pediatric lymphomas in sub-Saharan Africa. Plasmodium falciparum (Pf) malaria is considered an etiological factor BL. We describe the geographic distribution BL Malawi and association with prevalence (PfPR). also examine influence travel time to cancer referral center as a potential confounder. METHODS enrolled pathologically confirmed incident cases (2013-2018) into prospective observational cohort at Kamuzu Central Hospital (KCH) Lilongwe,...