A5013135418- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Palliative Care and End-of-Life Issues
- Global Cancer Incidence and Screening
- Esophageal and GI Pathology
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Mobile Health and mHealth Applications
- Patient-Provider Communication in Healthcare
- Colorectal Cancer Screening and Detection
- Advances in Oncology and Radiotherapy
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Diagnosis and Treatment
- Global Health and Surgery
- Health Systems, Economic Evaluations, Quality of Life
- Telemedicine and Telehealth Implementation
- Digital Mental Health Interventions
- Tracheal and airway disorders
- Advanced Radiotherapy Techniques
- Cervical Cancer and HPV Research
- Clinical practice guidelines implementation
- Diabetes, Cardiovascular Risks, and Lipoproteins
Muhimbili University of Health and Allied Sciences
2016-2025
Memorial University of Newfoundland
2019
Ocean Road Cancer Institute
2016-2018
Tenwek Hospital
2018
National Cancer Institute
2018
University of California, San Francisco
2018
PURPOSE Eastern Africa is one of several regions affected by high incidence rates esophageal squamous cell carcinoma (ESCC). A unique epidemiologic feature ESCC in the young people, with one-third cases diagnosed at age < 45 years. This study aimed to investigate risk factors for early-onset Tanzania through a secondary analysis matched case-control study. MATERIALS AND METHODS From 2013 2015, were recruited Muhimbili National Hospital and Ocean Road Cancer Institute Dar es Salaam,...
Background Women with breast cancer in sub-Saharan Africa are commonly diagnosed at advanced stages. In Tanzania, more than 80% of women stage III or IV disease, and mortality rates high. This study explored factors contributing to delayed diagnostic evaluation among Tanzania. Methods A qualitative was performed Muhimbili National Hospital Dar es Salaam, Twelve symptomatic pathologically proven were recruited. In-depth, semi-structured interviews conducted Swahili. Interviews the women’s...
Background Improving access to end-of-life symptom control interventions among cancer patients is a public health priority in Tanzania, and innovative community-based solutions are needed. Mobile technology holds promise; however, existing resources limited, outpatient palliative care specialists poor. A mobile platform that extends specialist via shared with local workers (LHWs) provides remote support for pain other management can address this gap. Objective The aim of study design develop...
Age-standardized incidence rates for esophageal cancer (EC) in East Africa have been reported as disproportionately high compared with the worldwide of nine per 100,000 population. This study aimed to characterize EC cases seen at Muhimbili National Hospital and Ocean Road Cancer Institute Dar es Salaam, Tanzania.Demographic, clinical, treatment variables were abstracted from charts patients who received care a diagnosis one or both institutions between 2011 2013. Categorical data summarized...
The incidence of esophageal squamous cell carcinoma (ESCC) is disproportionately high in the eastern corridor Africa and parts Asia. Emerging research has identified a potential association between poor oral health ESCC. One possible link ESCC involves alteration microbiome. We performed an integrated analysis four independent sequencing efforts tumors from patients high- low-incidence regions world. Using whole genome (WGS) RNA (RNAseq) 61 Tanzania, we community bacteria, including members...
Late-stage cancer patient symptom control is a national priority in Tanzania. Mobile health promises to improve the reach of limited pool palliative care specialists through interprofessional, community-based coordination. This work assessed effectiveness smartphone- or Web-based app, mPalliative Care Link (mPCL), extend specialist access via shared data and communication with local workers. Central mPCL African Palliative Outcome Scale (POS), adapted for automated mobile assessment...
Abstract Background Despite recent international efforts to develop resource-stratified clinical practice guidelines for cancer, there has been little research evaluate the best strategies dissemination and implementation in low- middle-income countries (LMICs). Guideline publication alone is insufficient. Extensive shown that structured, multifaceted target barriers guideline use are most likely improve adherence; however, of this conducted high-income countries. There a pressing need...
Fine-needle aspiration biopsy (FNAB) is a minimally invasive, cost-effective diagnostic tool that can be used in low-resource settings. However, adequacy and accuracy of FNAB highly dependent on the skills operator requires specialized training. Poor technique preclude definitive diagnoses because insufficient quality or quantity samples. We evaluated efficacy an intensive training experience Tanzania improving ultrasound-guided techniques.A 2-day workshop offered didactic lectures,...
Esophageal squamous cell carcinoma (ESCC) is a major cause of cancer morbidity and mortality in Eastern Africa. The majority patients with ESCC Africa present advanced disease at the time diagnosis. Several palliative interventions for are currently use within region, including chemotherapy, radiation therapy without esophageal stenting self-expandable metallic stents; however, comparative effectiveness these low resource setting has yet to be examined. This prospective, observational,...
Abstract Background Symptom control among cancer patients is a Tanzanian public health priority impacted by limited access to palliative care (PC) specialists and resources. Mobile Palliative Care Link (mPCL), mobile/web application, aims extend specialist via shared with local workers (LHWs) the African Outcome Scale (POS) adapted for regular, automated symptom assessment as core feature. Objective The aim of study assess clinicians' attitudes, beliefs, perceptions regarding mPCL usability...
Context.— Rapid onsite evaluation (ROSE) is critical in determining sample adequacy and triaging cytology samples. Although fine-needle aspiration biopsy (FNAB) the primary method of initial tissue sampling Tanzania, ROSE not practiced. Objective.— To investigate performance cellular providing preliminary diagnoses breast FNAB a low-resource setting. Design.— Patients with masses were recruited prospectively from clinic at Muhimbili National Hospital. Each was evaluated by for overall...
In response to the increasing burden of cancer in Tanzania, Ministry Health, Community Development, Gender, Elderly and Children launched National Cancer Treatment Guidelines (TNCTG) February 2020. The guidelines aimed improve standardize oncology care country. At Ocean Road Institute (ORCI), we developed a theory-informed implementation strategy promote guideline-concordant care. As part situation analysis for development, conducted focus group discussions evaluate clinical systems...
The eastern corridor of Africa is affected by a high burden esophageal cancer (EC), with > 90% patients presenting advanced disease. Self-expanding metal stents (SEMS) have been previously reported as safe and effective for palliation malignant dysphagia in resource-limited settings; however, access limited throughout Eastern Africa.
Abstract 75 Objective: East Africa has been previously reported as a geographic area with disproportionately high incidence of squamous cell esophageal cancer (EC). In the setting an apparent cluster, we sought to identify specific etiologic factors contributing EC in Tanzania (TZ). Methods: We performed case-control study examine possible associations between and selected environmental, dietary, lifestyle factors. Newly diagnosed cases were recruited at Muhimbili National Hospital Ocean...
PURPOSE Tracheostomy and gastrostomy tube interventions are common procedures for patients with head neck esophageal cancer, which both highly prevalent at Muhimbili National Hospital (MNH), the largest referral hospital in Tanzania. Reported complications lead to unplanned readmissions increased disease burden, negatively impacting patient outcomes. While there described approaches quality improvement these procedures, have mostly been high-income countries. We aimed study MNH Tanzania...
<div>Abstract<p>Background: Esophageal squamous cell carcinoma (ESCC) comprises 90% of all esophageal cancer cases globally and is the most common histology in low-resource settings. Eastern Africa has a disproportionately high incidence ESCC. Methods: We describe genomic profiles 61 ESCC from Tanzania compare them to an existing cohort Malawi. also provide comparison tumors The Cancer Genome Atlas. Results: observed substantial transcriptional overlap with other histologies via...
<p>Supplementary Figure S2. Expression of Mutsig CV genes in cohorts from Tanzania (Panel A) and Malawi B).</p>
<p>Supplementary Figure S1. Measurement of RNA Quantity and Quality using PAXgene tissue container vs. RNAlater.</p>