A5026975441- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Economic and Financial Impacts of Cancer
- Chronic Lymphocytic Leukemia Research
- Global Cancer Incidence and Screening
- Acute Lymphoblastic Leukemia research
- Polyomavirus and related diseases
- Air Quality and Health Impacts
- Neutropenia and Cancer Infections
- Hematological disorders and diagnostics
- HIV Research and Treatment
- Histiocytic Disorders and Treatments
- HIV/AIDS drug development and treatment
- Climate Change and Health Impacts
- Adolescent and Pediatric Healthcare
- Cervical Cancer and HPV Research
- Energy and Environment Impacts
- Tuberculosis Research and Epidemiology
- Mobile Health and mHealth Applications
- Digital Imaging for Blood Diseases
- Lymphadenopathy Diagnosis and Analysis
- High Altitude and Hypoxia
- Mycobacterium research and diagnosis
University of Malawi
2018-2024
University of North Carolina at Chapel Hill
2018-2024
UNC Lineberger Comprehensive Cancer Center
2018-2024
University of North Carolina Health Care
2024
Johns Hopkins Medicine
2013-2015
Johns Hopkins University
2013-2015
Washington University in St. Louis
2013
University of Minnesota
2005
Human embryonic stem (hES) cells provide an important means to evaluate specific soluble and cell-bound stimuli that regulate development of cell lineages. Here, we examined cytokines extracellular matrix (ECM) proteins support differentiation hES hepatocytes. Tests several different conditions determined addition fibroblast growth factor (FGF)-4 hepatocyte in completely serum-free cultures cell-derived embryoid bodies subsequently allowed attach type I collagen-coated dishes led maximal...
<h3>Background</h3> Biomass fuels are used for cooking in the majority of rural households worldwide. While their use is associated with an increased risk lung diseases and all-cause mortality, effects on cardiovascular disease (CVD) not well characterised. Exposure to biomass fuel smoke has been lung-mediated inflammation oxidative stress, which may increase atherosclerosis as evaluated by carotid intima-media thickness (CIMT), atherosclerotic plaque prevalence blood pressure....
Stigma is an impediment across the cancer care continuum, leading to delayed presentation care, elevated morbidity and mortality, reduced quality of life. The goal this study was qualitatively examine drivers, manifestations, impacts cancer-related stigma among individuals who received treatment in Malawi, identify opportunities address stigma.
There are no clinical trials involving patients with diffuse large B-cell lymphoma (DLBCL) in sub-Saharan Africa since antiretroviral therapy (ART) for HIV became widely available this region. We aimed to establish the safety and efficacy of rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP) DLBCL Malawi.
Abstract Kaposi sarcoma (KS) is the most common cancer in people living with HIV (PLWH) many countries where KS‐associated herpesvirus endemic. Treatment has changed little 20 years, but disease presentation has. This prospective cohort study enrolled 122 human immunodeficiency virus (HIV) positive KS patients between 2017 and 2019 Malawi. Participants were treated bleomycin, vincristine combination antiretroviral therapy, local standard of care. One‐year overall survival was 61%,...
BackgroundABVD (doxorubicin, bleomycin, vinblastine, and dexamethasone) is a proven, curative regimen for Hodgkin lymphoma (HL). Prospective data describing HL treatment in sub-Saharan Africa are limited. We aimed to fill this knowledge gap, using from Malawi.MethodsWe report prospective observational cohort of (aged ≥ 15) single, tertiary referral centre Malawi. enrolled patients with pathologicially confirmed between June 1, 2013, Dec 31, 2021 follow-up censored on May 2022. Patients were...
Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV highly endemic. We identified 12 patients with pathologically confirmed PBL a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26–71), seven (58%) were male, six (50%) HIV-positive. Eight treated CHOP four modified EPOCH regimen. One-year overall survival 56% (95% CI 24–79%), without clear differences based on status. occurs Malawi HIV-positive HIV-negative...
Outcomes for diffuse large B-cell lymphoma (DLBCL) in sub-Saharan Africa (SSA) are poorly described. We report mature data from one of the first prospective SSA cohorts. Patients aged ≥18 years with DLBCL were enrolled Malawi 2013-2017. Participants treated CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy and concurrent antiretroviral therapy (ART) if positive human immunodeficiency virus (HIV+). Eighty-six participants (mean age 47 years, standard deviation 13)...
Abstract Burkitt lymphoma (BL) is common in sub-Saharan Africa (SSA). In high-income countries, BL highly curable with chemotherapy. However, there are few prospective studies from SSA describing nonpediatric and no regional standard of care. Thirty-five participants age 15 years or older newly diagnosed were enrolled Malawi 2013 to 2018. Chemotherapy was administered according institutional guidelines, concurrent antiretroviral therapy if HIV infected. Median 21 (range, 15-61) (43%)...
Painschab, Matthew S., Gary E. Malpartida, Victor G. Davila-Roman, Robert H. Gilman, Todd M. Kolb, Fabiola Leon-Velarde, J. Jaime Miranda, and William Checkley. Association between serum concentrations of hypoxia inducible factor responsive proteins excessive erythrocytosis in high altitude Peru. High Alt Med Biol 16:26-33, 2015.-Long-term residence at is associated with the development chronic mountain sickness (CMS), which characterized by (EE). EE occurs under hypoxia, a strongly selected...
Abstract Plasma Epstein‐Barr virus (EBV) DNA measurement has established prognostic utility in EBV‐driven lymphomas, where it serves as a circulating tumor marker. The value of plasma EBV may be amplified sub‐Saharan Africa (SSA), advanced imaging and molecular technologies for risk stratification are not typically available. However, its diffuse large B‐cell lymphoma (DLBCL) is less certain, given that only subset DLBCLs EBV‐positive. To explore this possibility, we measured at diagnosis...
Aggressive non-Hodgkin lymphoma (NHL) is among the most common cancers in sub-Saharan Africa (SSA), where CHOP standard treatment and outcomes are poor. To address this, we treated 17 newly diagnosed adult patients Malawi with Burkitt (n = 8), plasmablastic primary effusion 1) a modified EPOCH regimen between 2016 2019. Twelve (71%) were male median age was 40 years (range 16-63). Eleven (65%) HIV infected, CD4 count 218 cells/µL 9-460), nine (82%) had suppressed RNA < 400 copies/mL....
Cost-effectiveness data for cancer treatment are needed from sub-Saharan Africa, where diffuse large B-cell lymphoma (DLBCL) is a common, curable cancer. In high-income countries, the standard of care DLBCL R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) chemoimmunotherapy. Rituximab often not available in Africa due to perceived unaffordability, with CHOP (cyclophosphamide, common. We aimed evaluate cost-effectiveness Malawi, comparing best supportive care,...
The pathology laboratory at Kamuzu Central Hospital (KCH) in Lilongwe, Malawi was established 2011. We published our initial experiences development and telepathology 2013 2016, respectively. purpose of this paper is to provide an update on work by highlighting the positive role has played improving regional cancer care research. In addition, we a summary adult data from specimens received between July 1, 2011, May 31, 2019, with emphasis malignant diagnoses. compare these summaries...
PURPOSE Kamuzu Central Hospital (KCH) in Lilongwe, Malawi serves a population of 10 million from the country’s and Northern regions. However, KCH is one just 2 centers country providing care to cancer patients, leaving majority with burden travelling long distances for diagnosis treatment. Spatial barriers care, particularly relation travel time clinic, are not well defined adults hematologic malignancies may contribute disparities treatment outcomes. Therefore, it important understand...
Kaposi sarcoma-associated herpes virus (KSHV), also known as human 8 (HHV-8), is the primary etiologic cause of sarcoma (KS) and KSHV Inflammatory Cytokine Syndrome (KICS). Patients with KICS demonstrate symptoms systemic inflammation, high viral load, elevation inflammatory markers, increased mortality. Management requires rapid diagnosis, treatment underlying HIV, direct KS, addressing hyperimmune response. While a case definition based on clinical presentation, imaging findings,...
Cancer outcomes in sub-Saharan Africa (SSA) remain suboptimal, part due to poor patient retention. Many patients travel long distances receive care, and transportation costs are often prohibitively expensive. These well-known established causes of delayed treatment care abandonment Malawi across SSA. We sent visit reminder texts offered upfront money cover through a mobile transfer (MMT) platform lymphoma enrolled prospective cohort Malawi. The primary aim was test the feasibility MMTs. 1034...