A5029484111- Gene expression and cancer classification
- RNA modifications and cancer
- RNA Research and Splicing
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Chromatin Dynamics
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Animal Behavior and Reproduction
- Diabetes and associated disorders
- Advanced Biosensing Techniques and Applications
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Chemical Synthesis and Analysis
- Lymphoma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Neurobiology and Insect Physiology Research
- Viral-associated cancers and disorders
- Olfactory and Sensory Function Studies
- Digital Image Processing Techniques
- Bioinformatics and Genomic Networks
- Diabetes Management and Research
- Animal Vocal Communication and Behavior
- Synthesis and Reactions of Organic Compounds
- Pancreatic function and diabetes
- melanin and skin pigmentation
University of Massachusetts Chan Medical School
2024
University of North Carolina at Chapel Hill
2024
University of Utah
2023
Centre Interdisciplinaire de Recherche en Biologie
2018-2022
Inserm
2010-2022
Collège de France
2018-2022
Centre National de la Recherche Scientifique
2010-2022
Université Paris Sciences et Lettres
2022
LEIZA - Leibniz-Zentrum für Archäologie
2021
Loyola University Chicago
2021
The periodic stripes and spots that often adorn animals' coats have been largely viewed as self-organizing patterns, forming through dynamics such Turing's reaction-diffusion within the developing skin. Whether preexisting positional information also contributes to periodicity orientation of these patterns has, however, remained unclear. We used natural variation in colored juvenile galliform birds show form a two-step process. Autonomous signaling from somite sets stripe position by...
In the field of bioinformatics, exon profiling is a developing area disease-associated transcriptome analysis. this study, we performed microarray-based analysis at single level in mouse 4T1 primary mammary tumors with different metastatic capabilities. A novel bioinformatics platform was developed that identified 679 genes differentially expressed exons tumors, many which were involved cell morphology and movement. Of 152 alternative tested by reverse transcription-PCR, 97 validated as...
The cohesin complex is a key player in regulating cell division. Cohesin proteins SMC1, SMC3, Rad21, and stromalin (SA), along with associated Nipped-B, Pds5, EcoI, maintain sister chromatid cohesion before segregation to daughter cells during anaphase. Recent chromatin immunoprecipitation (ChIP) data reveal extensive overlap of Nipped-B components RNA polymerase II binding at active genes Drosophila . These other strongly suggest role for transcription; however, there no clear evidence any...
Elucidating how cancer cells respond to antagonists of HER receptor family members is critical understanding mechanisms therapeutic resistance that arise in patients. In large part, such agents appears from deregulation the phosphatidylinositol-3-kinase (PI3K)/Akt/mTOR pathway. mTOR-dependent phosphorylation translation repressor 4E-BP1 leads its dissociation eIF4E, thereby causing an increase formation eIF4F complex, which also comprises eIF4G and eIF4A. this study, we show trastuzumab,...
Chronic kidney disease is promoted by a variety of factors that induce chronic inflammation and fibrosis. Inflammation excessive scaring have been recently associated with disruptions the gap junction-mediated intercellular communication. Nevertheless, little known about alterations expression junction proteins such as connexin (Cx) 43 37 in renal disease. In this study, we investigated these two Cxs hypertensive RenTg mice, anti-glomerular basement membrane glomerulonephritis, unilateral...
The color patterns that adorn animals’ coats not only exhibit extensive diversity linked to various ecological functions but also display recurrences in geometry, orientation, or body location. How processes of pattern formation shape such phenotypic trends remains a mystery. Here, we surveyed plumage passerine finches displaying extreme apparent variation and identified conserved set domains. We these domains putative embryonic skin regions instructed by early developmental tissues outlined...
Oligonucleotides containing CpG motifs (cytosine-phosphate-guanosine oligodeoxynucleotide [CpG ODN]) display strong immunostimulatory effects, and polycations have been previously reported as cellular delivery system. In the present study, we investigated adjuvant properties of combinations a ODN with various (poly-arginine, poly-lysine, poly-histidine, or chitosan) in an ovalbumin vaccination model. We showed that, when combined to ODN, poly-arginine but not poly-lysine chitosan, enhanced...
Objectives Diabetes mellitus is a common condition that requires intensive treatment and markedly impacts the welfare of affected cats. The aim this study was to identify diabetes mellitus‐associated perturbations in feline pancreatic islet microenvironment. utility “clear, unobstructed brain/body imaging cocktails computational analysis” (CUBIC) for three‐dimensional analysis investigated. Methods Formalin‐fixed paraffin‐embedded tissues from cats with mellitus, or control without...
Abstract Many animals exhibit typical color patterns that have been linked to key adaptive functions, yet the developmental mechanisms establishing these crucial designs remain unclear. Here, we surveyed distribution in plumage across a large number of passerine finches. Despite extreme apparent pattern diversity, identified small set conserved regions whose combinatory association can explain all observed patterns. We found domains are instructed by early embryonic landmarks, and through...
Meningiomas (MN) are one of the most common types brain tumors and categorized by World Health Organization (WHO) in three grades according to severity, with grade III MNs being aggressive; patients diagnosed latter do not have a positive prognosis. Increased malignancy correlates genetic heterogeneity, which is partly responsible for difficulty finding chemical treatment. As now, surgical resection best option treatment high MNs, however, failure excise all cancerous tissue can lead...
Supplementary Figures 1-11 from Exon-Based Clustering of Murine Breast Tumor Transcriptomes Reveals Alternative Exons Whose Expression Is Associated with Metastasis
Supplementary Figure Legends 1-11, Table 1-3, Methods from Exon-Based Clustering of Murine Breast Tumor Transcriptomes Reveals Alternative Exons Whose Expression Is Associated with Metastasis
Supplementary Figures 1-11 from Exon-Based Clustering of Murine Breast Tumor Transcriptomes Reveals Alternative Exons Whose Expression Is Associated with Metastasis