A5000866897- Veterinary Oncology Research
- Milk Quality and Mastitis in Dairy Cows
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Microbial infections and disease research
- Infectious Diseases and Mycology
- Pancreatic function and diabetes
- Rabbits: Nutrition, Reproduction, Health
- Neonatal Respiratory Health Research
- Cancer Diagnosis and Treatment
- Diabetes Management and Research
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- Veterinary Medicine and Surgery
- Infant Nutrition and Health
- Immunotherapy and Immune Responses
- Digestive system and related health
- Cancer and Skin Lesions
- Diabetes Treatment and Management
- Virus-based gene therapy research
- Cancer Risks and Factors
- Diabetes and associated disorders
- Cell Adhesion Molecules Research
- Breast Lesions and Carcinomas
- Cancer-related molecular mechanisms research
University of Cambridge
2016-2025
NHS Greater Glasgow and Clyde
2022-2025
Naval Medical Center San Diego
2025
Glasgow Royal Infirmary
2022-2025
University of Leeds
2024
Queen's Hospital
2017-2022
Zoological Society of London
2022
Institute of Cancer Research
2022
University of Arizona
2022
The University of Queensland
2022
Salmonellosis is one of the leading causes food poisoning worldwide. Controlling bacterial burden essential to surviving infection. Nucleotide-binding oligomerization domain-like receptors (NLRs), such as NLRC4, induce inflammasome effector functions and play a crucial role in controlling Salmonella Inflammasome-dependent production IL-1β recruits additional immune cells site infection, whereas inflammasome-mediated pyroptosis macrophages releases bacteria for uptake by neutrophils. Neither...
Abstract Mammary gland regression following weaning (involution) is associated with extensive cell death and the acquisition of an inflammatory signature. Characterizing interplay between mammary epithelial cells, re‐emerging stroma immune cells has implications for understanding pathogenesis pregnancy‐associated breast cancer. Stat3 a role in orchestrating involution, we sought to determine whether expression by epithelium also influences innate environment influx gland. We examined mice...
The aetiology of genital squamous cell carcinoma (SCC) in horses remains unknown, but the similarity to disease man, for which papillomavirus infection has been shown be a causal factor, requires investigated horses.One or more novel papillomaviruses cause equine SCC and its associated premalignant lesions.DNA was extracted from samples performed rolling circle amplification, order identify closed circular DNA viral genomes within samples. amplified subcloned sequenced sequence compared that...
Abstract Anaplastic large cell lymphoma (ALCL) is a peripheral T-cell presenting mostly in children and young adults. The natural progression of this disease largely unknown as the identity its true origin. Here we present model ALCL pathogenesis where malignancy initiated early thymocytes, before receptor (TCR) β-rearrangement, which bypassed CD4/NPM–ALK transgenic mice following Notch1 expression. However, find that TCR required for thymic egress development murine tumours, yet must be...
Abstract The Wnt signalling pathway, one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL), is activated only a subset patients through somatic mutations. Here we describe alternative, microenvironment-dependent mechanisms activation malignant B cells. We show that tumour cells specifically induce Notch2 activity mesenchymal stromal (MSCs) required for transcription complement factor C1q. MSC-derived C1q turn inhibits Gsk3-β mediated degradation β-catenin CLL...
Low Density Granulocytes (LDGs), which appear in the peripheral blood mononuclear cell layer of density-separated blood, are seen cancer, sepsis, autoimmunity and pregnancy. Their significance ANCA vasculitis (AAV) is little understood. As these cells bear autoantigens associated with this condition have been found to undergo spontaneous NETosis other diseases, we hypothesised that they were key drivers vascular inflammation. We LDGs comprise a 3-fold higher fraction total granulocytes...
Mammary gland development begins in the embryo and continues throughout reproductive life of female mammals. Tissue macrophages (Mϕs), dependent on signals from Mϕ colony stimulating factor 1 receptor (CSF1R), have been shown to regulate generation, regression regeneration this organ, which is central for mammalian offspring survival. However, distribution Mϕs pre- post-natal mammary gland, as it undergoes distinct phases regression, unknown or has inferred immunostaining thin tissue...
Abstract Background Newer glucose-lowering agents for type 2 diabetes (sodium glucose cotransporter inhibitors (SGLT2i), glucagon-like peptide-1 receptor analogues (GLP1ra) and dipeptidyl peptidase-4 (DPP4i)) improve hyperglycaemia SGLT2i GLP1ra reduce the risk of major adverse cardiovascular events (MACE). It is not clear whether efficacy these varies by age. Methods We searched Medline Embase, plus clinical trial registries, randomised controlled trials SGLT2i, DPP4i, versus placebo or...
Toll-like receptor-4 (TLR4) is important in protection against lethal Salmonella enterica serovar Typhimurium (S. Typhimurium) infection. Control of the early stages sublethal S. infection mice depends on TLR4-dependent activation macrophages and natural killer (NK) cells to drive an inflammatory response. TLR4 signals through adapter proteins Mal/MyD88 TRIF-related adaptor molecule (TRAM)/TIR-domain-containing adaptor-inducing interferon-b (TRIF). In mouse typhoid model we showed that...
Copy-number gain of the oncostatin-M receptor (OSMR) occurs frequently in cervical squamous cell carcinoma (SCC) and is associated with adverse clinical outcome. We previously showed that OSMR overexpression renders SCC cells more sensitive to major ligand (OSM), which increases migration invasion vitro. hypothesised a contribution this phenotype would come from epithelial-mesenchymal transition (EMT).We performed comprehensive integrated study, involving vitro line studies, vivo animal...
Abstract Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence haplotypes under positive selection ‘selfish’ traits, such as replicative advantage. However, few cases this phenomenon arising within natural populations have been described. Here, we survey frequency mtDNA horizontal transfer canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires from its hosts....
The adult mammary gland undergoes dynamic changes during puberty and the postnatal developmental cycle. epithelium is composed of a bilayer outer basal, or myoepithelial, cells inner luminal cells, latter lineage giving rise to milk‐producing alveolar pregnancy. These undergo Stat3‐mediated programmed cell death following cessation lactation. It established that immune in microenvironment have role play both ductal outgrowth removal dead remodelling stroma process postlactational regression....
In rabbits, a white-spotted liver can be indicative of one several disease processes, frequently caused by parasites. To date, the prevalence in wild Oryctolagus cuniculus, United Kingdom is undetermined. We evaluated and main parasitic etiologies this entity U.K. population rabbits. Wild rabbits (n = 87) were shot Cambridgeshire for control, cadavers donated research. Postmortem examination was undertaken, including gross histologic hepatic examination. Macroscopic lesions consistent with...
The oncostatin M (OSM) receptor (OSMR) shows frequent gene copy number gains and overexpression in cervical squamous cell carcinomas (SCCs), associated with adverse clinical outcomes. In SCC cells that overexpress OSMR, the major ligand OSM induces multiple pro-malignant effects, including invasion, secretion of angiogenic factors, metastasis. Here, we demonstrate, for first time, OSMR activates cell-autonomous feed-forward signalling, via further expression sustained STAT3 activation,...
At the start of 2018, multiple incidents dog illnesses were reported following consumption marine species washed up onto beaches eastern England after winter storms. Over a two-week period, nine confirmed including two canine deaths recorded. Symptoms in affected dogs included sickness, loss motor control, and muscle paralysis. Samples flatfish, starfish, crab from areas analysed for suite naturally occurring neurotoxins dinoflagellate origin. Toxins causing paralytic shellfish poisoning...