Edward M. Donelan
A5023973948- Veterinary Oncology Research
- Virus-based gene therapy research
- Genomics and Phylogenetic Studies
- Infectious Diseases and Mycology
- Microbial infections and disease research
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- Hedgehog Signaling Pathway Studies
- Evolution and Genetic Dynamics
- Human-Animal Interaction Studies
Centre for Rural and Remote Mental Health
2016
Canine transmissible venereal tumor (CTVT) is the oldest known somatic cell lineage. It a cancer that propagates naturally in dogs. We sequenced genomes of two CTVT tumors and found has acquired 1.9 million substitution mutations bears evidence exposure to ultraviolet light. remarkably stable lacks subclonal heterogeneity despite thousands rearrangements, copy-number changes, retrotransposon insertions. More than 10,000 genes carry nonsynonymous variants, 646 have been lost. first arose dog...
Canine transmissible venereal tumour (CTVT) is a clonally cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of CTVT nuclear genome, mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs global population CTVTs, show mtDNA horizontal transfer has occurred at least five times, delineating clades whose distributions track two millennia dog migration. Negative...
The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by "metastasizing" between hosts through cell transfer. somatic mutations in this record its phylogeography evolutionary history. We constructed time-resolved phylogeny from 546 CTVT exomes describe the lineage's worldwide expansion. Examining variation mutational exposure, we identify highly context-specific process operated early cancer's evolution but subsequently vanished,...
Abstract Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence haplotypes under positive selection ‘selfish’ traits, such as replicative advantage. However, few cases this phenomenon arising within natural populations have been described. Here, we survey frequency mtDNA horizontal transfer canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires from its hosts....
Summary Although somatic cell genomes are usually entirely clonally inherited, nuclear DNA exchange between cells of an organism can occur sporadically by fusion, phagocytosis or other mechanisms 1–3 . This phenomenon has long been noted in the context cancer, where it could be envisaged that horizontal transfer plays a functional role disease evolution 4–13 However, understanding frequency and significance this process naturally occurring tumours is lacking. The host-tumour genetic...