A5063465707- COVID-19 Clinical Research Studies
- MicroRNA in disease regulation
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Systemic Lupus Erythematosus Research
- Circular RNAs in diseases
- Rheumatoid Arthritis Research and Therapies
- Bacteriophages and microbial interactions
- Cardiovascular Disease and Adiposity
- Vitamin D Research Studies
- Inflammasome and immune disorders
- Hepatitis C virus research
- Phytochemistry and Biological Activities
- Synthesis and biological activity
- Respiratory Support and Mechanisms
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Microbial infections and disease research
- Adrenal Hormones and Disorders
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Genomics and Phylogenetic Studies
Beni-Suef University
2017-2025
Minia University
2022
Taif University
2022
Cairo University
2022
National Veterinary Research Institute
2002-2020
Taraba State University
2020
The Ohio State University
2016
Interface (United States)
2016
Lung Institute
2016
Ahmadu Bello University
2015
Autophagy is a biological process characterized by self-digestion and involves induction of autophagosome formation, leading to degradation autophagic cargo. Aging associated with the reduction autophagy activity neurodegenerative disorders, chronic inflammation, susceptibility infection; however, underlying mechanism unclear. DNA methylation methyltransferases reduces expression corresponding genes. Since macrophages are major players in inflammation defense against infection we determined...
Cystic fibrosis (CF) is a fatal, genetic disorder that critically affects the lungs and directly caused by mutations in CF transmembrane conductance regulator (CFTR) gene, resulting defective CFTR function. Macroautophagy/autophagy highly regulated biological process provides energy during periods of stress starvation. Autophagy clears pathogens dysfunctional protein aggregates within macrophages. However, this impaired patients mice, as their macrophages exhibit limited autophagy activity....
Artemisia herba alba & monosperma: The Discovery of the first potential Egyptian plant sources for Pharmaceutical Commercial Production Artemisinin and Some Its Related AnaloguesEl Motaz Bellah El Maggar
Abstract Background Successful treatment of pathogenic bacteria like Enterobacter Cloacae with bacteriophage (phage) counteract some hindrance such as phage stability and immunological clearance. Our research is focused on the encapsulation HK6 within chitosan nanoparticles. Result Encapsulation significantly improves stability, efficacy, delivery phages. Chitosan nanoparticles (CS-NPs) achieve a entrapment efficiency 97%. Fourier-transform infrared spectroscopy (FT-IR) reveals shifts...
Background: Diabetic nephropathy (DNP) is a type 2 diabetes mellitus (T2DM) chronic complication, which the largest single cause of end-stage kidney disease. There an increasing evidence role inflammation and Toll-like receptors (TLRs) as part innate immune system in its development progression. In addition, receptor (TLR2) 4 (TLR4) downward signaling causes production proinflammatory cytokines, can induce insulin (INS) resistance T2DM. Objective: The goal this study was to estimate...
Lung cancer is the primary cause of cancer-related death worldwide, and development novel lung preventive therapeutic agents are urgently needed. Brassica nigra (black mustard) seeds commonly consumed in several Asian African countries. Mustard previously exhibited significant anticancer activities against types. In present study, we have investigated various cellular molecular mechanisms effects an ethanolic extract B. A549 H1299 human non-small cell lines. showed a substantial...
COVID-19 impacts the cardiovascular system resulting in myocardial damage, and also affects kidneys leading to renal dysfunction. This effect is mostly through binding with angiotensin-converting enzyme 2 (ACE2) Neuropilin-1 (NRP-l) receptors. Toll-Like Receptors (TLRs) typically combine microbial pathogens provoke an inflammatory response.This work aims compare changes kidney heart function bioindicators expressions of TLRs (TLR2 TLR2) as well ACE2 NRP-l receptors moderate severe patients....
Higher expression of angiotensin-converting enzyme-2 (ACE-2) in addition to neuropilin-1 (NRP-1) can lead a cytokine storm which is correlated higher mortality rate and contributes the progression renal diseases pathogenesis coronary heart disease (CHD) COVID-19 patients.We herein sought examine correlations between levels, ACE-2 NRP-1 expression, function biomarkers, cardiac enzymes patients.For study, 50 healthy subjects 100 patients were enrolled. Then, confirmed cases divided into two...
The primary factor causing chronic renal failure is diabetic nephropathy (DN) worldwide. However, the current biomarkers for DN have limited diagnostic utility. Thus, this work aimed to clarify implications of microRNA-200a (miR-200a) and microRNA-132 (miR-132) their correlation with NF-κB (nuclear factor- kappa beta), and, TNF-α (tumor necrosis -alpha) signaling identify able distinguish late-stage from early- stage DN.
Background Colorectal cancer (CRC) is a type that thought to be influenced by human papillomaviruses (HPVs) and polyomaviruses (HPyVs). In Egypt, CRC ranks as the 7th most common cancer, accounting for 3.47% of male cancers 3% female cancers. However, there currently lack information regarding presence PyVs HPVs co-infection specifically in cases Egypt. Therefore, aim this study was investigate occurrence HPyVs (JCPyV, BKPyV, SV40) infections, well co-infections, among patients Additionally,...
Abstract Background A novel corona virus called SARS-CoV-2 was identified at the end of December 2019, and illness induced by it designated as coronavirus disease 2019 (COVID-19). Severity could vary significantly since most infected individuals experience mild to moderate respiratory symptoms recover without specialized care. Genetic polymorphisms have implications in influencing varying degrees COVID-19 severity. This study aims assess potential association between CXCL12 rs2839693...
Abstract Objective Nephropathy is among the most pervasive complications of diabetes; it frequently results in end-stage renal disease and even death. However, current biomarkers for diabetic nephropathy (DN) have limited diagnostic utility. Thus, this present study aims to examine associations estimated glomerular filtration rate (eGFR) with plasma concentrations microRNA-192 (miR-192), pentraxin-3 (PTX-3), transforming growth factor-beta1 (TGF-β1) identify able distinguish late-stage from...
Increased prevalence of Enterobacter cloacae within food products underscores as an underexplored reservoir for antibiotic resistance, thus requiring particular intervention. Bacteriophages have been explored a promising approach controlling bacterial growth in different matrices. Moreover, their specific interaction and self-replication, put them apart from traditional methods bacteria
Aim: The study evaluated the correlations between cytokine levels, liver function markers, and neuropilin-1 (NRP-1) expression in patients with COVID-19 Egypt. also aimed to evaluate accuracy sensitivity, specificity, area under curve (AUC) of tested laboratory parameters identifying infection its severity. Patients Methods: Fifty healthy subjects 100 confirmed were included this study. separated into two groups based on severity their symptoms. Serum ALT, AST, albumin, C-reactive protein...
The need of extremophile enzymes is increased.Such had found their utility in bio-industries such as leather, food, animal feed, textiles, and bioconversions bioremediation.Screening microorganisms producing from different areas soil led to the isolation 38 isolates, isolates were plate-screened for ability produce extracellular enzymes.The promising strains selected screened enzyme thermostability quantitatively potential industrial therapeutic applications.Tolerance was investigated a...
Abstract Background COVID-19 impacts the cardiovascular system resulting in myocardial damage and also affects kidneys leading to renal dysfunction. This effect is mostly through binding with angiotensin-converting enzyme-2 (ACE2) Neuropilin-1(NRP-l) receptors. Toll-Like Receptors (TLRs) typically combine microbial pathogens provoke an inflammatory response. Aim work aims compare changes kidney heart function bioindicators expressions of TLRs (TLR2 TLR2) as well ACE2 NRP-l receptors moderate...
Although it has been shown that the long non-coding RNA (lncRNA) insulin-like growth factor type 1 receptor (IGF1R) antisense imprinted non-protein coding (IRAIN) is downregulated in leukaemia cell lines, its usefulness as a prognostic marker acute myeloid (AML) not yet thoroughly investigated. Here, we sought to determine whether expression of IRAIN associated with clinical outcome AML patients.Using quantitative real-time polymerase chain reaction (qRT-PCR), levels were assessed peripheral...