Abstract Background A novel corona virus called SARS-CoV-2 was identified at the end of December 2019, and illness induced by it designated as coronavirus disease 2019 (COVID-19). Severity could vary significantly since most infected individuals experience mild to moderate respiratory symptoms recover without specialized care. Genetic polymorphisms have implications in influencing varying degrees COVID-19 severity. This study aims assess potential association between CXCL12 rs2839693...

COVID-19 poses a serious risk, especially to the elderly. Additionally, has demonstrated blatant sex-specific bias, with men exhibiting more severe reaction and greater fatality rate. The aim of this study is assess genotypic allelic frequencies chemokine ligand CXCL12 rs2839693 its receptor CXCR4 rs2228014 according age sex. Also, evaluate interaction between sex other risk variables affects how is.The present conducted on 131 female 169 male Egyptian patients who admitted Assiut University...

By the end of December 2019, a new coronavirus, termed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged, and cause disease was named 2019 (COVID-19). Several genetic factors have been implicated in diverse responses to SARS-CoV-2 infection, such as C-X-C chemokine receptor 4 (CXCR4) rs2228014 polymorphism, which has previously studied various diseases but not explored context COVID-19 severity. The current study aimed assess association between polymorphism CXCR4 gene...

BACKGROUND: Immune Thrombocytopenia (ITP) is a common acquired hematological disease. Genetic polymorphisms play an important role in ITP pathogenesis and prognosis. TNF-α-induced protein 3 (TNFAIP3) negative regulator of NF-kB many signaling pathways. Several variants TNFAIP3 have been associated with various inflammatory autoimmune disorders. AIM: Our study aimed to the association single nucleotide (SNPs); rs2230926 & rs5029939 susceptibility, as well prognosis by follow up cases for...

Abstract BackgroundImmune Thrombocytopenia (ITP) is a relatively common acquired hematological disorder, affecting 2 to 4/100000 adults. Understanding of the pathogenesis ITP has been greatly improved with taking into consideration important role genetic variants. This study aimed at investigating incidence TNFAIP3 SNPs (rs2230926 and rs5029939) in primary Egyptian patients as well their response therapy addition linkage between two SNPs.Methods Resultsthe was conducted 110 diagnosed (PITP)...

BACKGROUND: Chronic myeloid leukemia (CML) is one of the most common hematological tumors. Gene candidate studies cleared association single genetic variants (SNVs) to risk and progression in CML. MicroRNA biogenesis genes disruption contributes a fundamental role carcinogenesis. AIM: We aimed determine between rs636832 rs2740348 SNVs AGO1 gene GEMIN4 gene, respectively, prognosis CML Egyptian patients with 5 years survival estimation. METHODS: The study was conducted on 110 newly diagnosed...

<br><b>Background</b><br>Preeclampsia (PE) is a common pregnancy-specific complication, characterized by hypertension and significant proteinuria at or after 20 weeks of pregnancy; it affects ∼ 5–10% pregnant women worldwide remains the second leading cause maternal perinatal morbidity mortality. Depletion antioxidant enzymes such as superoxide dismutase (SOD) might be associated with development PE.<br><b>Objective</b><br>This study aimed to investigate correlation Ala40Thr polymorphism...

Background and Objectives: Myeloproliferative neoplasms (MPNs) are Philadelphia negative disorders involving polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF). Although JAK2 mutation is almost involved, other several mutations linked to MPNs risk prognosis. TNFAIP3 genetic related cancers autoimmune diseases. Our study aimed demonstrate the effects of rs2230926_T/G &amp; rs5029939_C/G SNVs gene on prognosis V617F positive MPNs.&#x0D; Methods: Matched 2...