Abstract Background Monkeypox has emerged as a global health concern, necessitating preventive measures and awareness among healthcare students. Understanding nursing students’ fears, concerns, practices regarding can help improve preparedness response strategies. Aim This study aimed to assess the levels of fear, related monkeypox students at Beni Suef University, Egypt, during 2024–2025 academic year. Methods A cross-sectional descriptive design was employed, involving 505 systematically...

Abstract Background Ventilator‐associated pneumonia (VAP) is a frequent and severe complication among newborns in neonatal intensive care units (NICUs). It associated with elevated morbidity mortality rates, more extended hospital stays increased health costs. Implementing preventive bundles structured sets of evidence‐based practices reduces VAP incidence. As primary caregivers, nurses are critical consistently applying these measures NICU settings. Aim To evaluate the impact training...

Refractory or unexplained iron deficiency anemia accounts for about 15% of all cases. The endoscopic gastrointestinal workup sometimes fails to establish the cause and a considerable proportion patients regardless risk category fail respond oral supplementation. aim present study was assess etiological role Helicobacter pylori infection in adult Egyptian with refractory anemia.A case controlled composed 104 cases 70 age- gender-matched healthy controls. Patients were diagnosed according...

Immune thrombocytopenia (ITP) treatment has evolved recently. However, none of the treatments have only benefits without drawbacks. This study aimed to compare clinical outcomes and adverse drug patterns Eltrombopag, Romiplostim, Prednisolone + Azathioprine, High Dose-dexamethasone (HD-DXM) (control group), Rituximab in primary ITP Egyptian patients. All patients were initiated with corticosteroids, HD-DXM, as a first-line for first month immediately following diagnosis. Four hundred...

Primary immune thrombocytopenia (ITP) is an inflammatory autoimmune disease that can be managed with several treatment options. However, there a lack of comparative data on the efficacy these options in different phases disease. This study aimed to evaluate high-dose Dexamethasone (HD-DXM), Prednisolone + Azathioprine, Rituximab, Eltrombopag, and Romiplostim schedules persistent, chronic refractory or relapsed Egyptian ITP patients platelet count ≤30 × 109/L. The primary outcome measure was...

Abstract Background Immune thrombocytopenia (ITP) is characterized by immune response dysregulations. Cytotoxic T lymphocyte‐associated antigen‐4 (CTLA‐4) plays a central role in checkpoint pathways and preventing autoimmune diseases regulating tolerance. We aimed to explore the potential association between CTLA-4 gene polymorphisms ITP as well study their impact on therapy. Methods investigated two single‐nucleotide (SNPs; rs: 231775 3087243) using real-time PCR plasma levels of ELISA 88...

Abstract Aim The purpose of this study is to assess the effect a distance education training program on nurse interns' readiness for and their perceptions lifelong learning. Design A quasi‐experimental research approach with one‐group, pre/post‐test was used. Methods used carried out at Damanhour University's Faculty Nursing. 345 students. All nursing interns enrolled in 2020–2021 internship year. researchers employed that contained assessment as well questionnaire about perceived advantages...

Abstract Background Heavy menstrual bleeding is an important health problem in women of reproductive age and also one the most common symptoms with disorders. Data about frequency rare disorders are limited, population-based studies lacking, so we aimed to determine among presented heavy periods that cannot be attributed obvious problems. Methods Complete blood count profiles include activated partial thromboplastin time, prothrombin factor VIII activity assay, ristocetin cofactor activity,...

Atherosclerosis has been extensively studied in thalassemia major (TM) and sickle cell disease but not yet β intermedia (TI). Previous studies concerned with TM were performed children. TI patients usually live longer and, thus, are more prone to complications of atherosclerosis.In our study, we applied color Doppler for the determination arterial conduit flow velocities patients.For central circulation, measured right left middle cerebral arteries (MCAs) basilar artery (BA) mean velocity...

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder caused by antigen-specific T cells and antiplatelet autoantibodies that inhibit platelet production in the bone marrow or destroy platelets spleen. ITP a form of autoimmunity closely associated with inflammation. Corticosteroids are first-line therapy for ITP, total response rate 53–80%. However, corticosteroid significant side effects often ineffective patients corticosteroid-resistant -intolerant disease. Eltrombopag has been...

Acute myeloid leukemia (AML) is a potentially fatal hematological disease. Along with disease-related factors, patient-related in particular age, are strong predictor of outcome that influence treatment decisions. Many acute risk stratification models have been developed to predict the intensive chemotherapy. However, these did not include physical function assessments.This study investigated impact several namely performance status, and age on short-term outcomes chemotherapy cohort 50...

Abstract Background Side effects of antiviral therapies for hepatitis C, especially hematologic abnormalities, may decrease both therapeutic adherence and success rate. Adherence to therapy is essential achieve an early viral response (EVR), this vital attaining a sustained (SVR). Discontinuation anti-viral the only way prevent progressive thrombocytopenia; however, discontinuation reduce rate clearance SVR. Our aim study HCV on platelet count. One hundred sixty eight adult patients with...

Background: Thalassemia is the commonest type of chronic hemolytic anemia in Egypt. Despite recent advances management thalassemia, people do not receive satisfactory treatment. For such conditions, only patients’ survival important but their quality life (QOL) also important, which primarily driven by psychological and social constraints. Aims: This study explores various factors that affect QOL transfusion‐dependent adult thalassemia patients hence authorities who provide services to...

BACKGROUND: Immune Thrombocytopenia (ITP) is a common acquired hematological disease. Genetic polymorphisms play an important role in ITP pathogenesis and prognosis. TNF-α-induced protein 3 (TNFAIP3) negative regulator of NF-kB many signaling pathways. Several variants TNFAIP3 have been associated with various inflammatory autoimmune disorders. AIM: Our study aimed to the association single nucleotide (SNPs); rs2230926 & rs5029939 susceptibility, as well prognosis by follow up cases for...

Abstract BackgroundImmune Thrombocytopenia (ITP) is a relatively common acquired hematological disorder, affecting 2 to 4/100000 adults. Understanding of the pathogenesis ITP has been greatly improved with taking into consideration important role genetic variants. This study aimed at investigating incidence TNFAIP3 SNPs (rs2230926 and rs5029939) in primary Egyptian patients as well their response therapy addition linkage between two SNPs.Methods Resultsthe was conducted 110 diagnosed (PITP)...

Chronic immune thrombocytopenia (cITP) is characterized by dysregulation of the response. Until recently, role Th2-related cytokine gene polymorphisms was unclear. Interleukin 4 (IL-4) exerts its functions binding to three types IL-4 receptor (IL-4R) complexes. We aimed explore potential association between polymorphism IL-4Rα and cITP. investigated clinical impact (rs1801275) A>G single nucleotide (SNP) using polymerase chain reaction (PCR) followed restriction fragment length (RFLP) method...

Purpose: The current study assesses cyberbullying among university students and explores the role of student-teacher relationship virtual classroom community. Methods: A descriptive exploratory on four randomly selected colleges at Damanhour University/Egypt. Participants were recruited conveniently using an equal allocation 150 students/college (600 students). European Cyberbullying Intervention Project Questionnaire (ECIPQ), Rovai's Classroom Community Scale (RCCS), Student Version...

Abstract Background Thrombopoietin receptor agonists (TPO-RA) are a well-established treatment in patients with immune thrombocytopenia (ITP). Predictors of response to some lines ITP have been reported; yet, date there no predictors TPO-RA were identified. We aimed identify predictive factors adult avoid unwanted adverse effects and individualize the treatment. Patients methods investigated demographic features, clinical-laboratory data as well previous 48 who received for at least 3 months...