A5002076323- Retinoids in leukemia and cellular processes
- Estrogen and related hormone effects
- Fatty Acid Research and Health
- Antioxidant Activity and Oxidative Stress
- Biotin and Related Studies
- Skin Protection and Aging
- Child Welfare and Adoption
- Reproductive Health and Technologies
- Cancer, Lipids, and Metabolism
- Breast Cancer Treatment Studies
- LGBTQ Health, Identity, and Policy
- Cancer Risks and Factors
- Eicosanoids and Hypertension Pharmacology
The University of Texas MD Anderson Cancer Center
2018-2022
Broughton Hospital
2003
Abstract Obesity, a cause of subclinical inflammation, is risk factor for the development postmenopausal breast cancer and associated with poorer outcomes. Docosahexaenoic acid (DHA), an omega-3 fatty acid, possesses anti-inflammatory properties. We hypothesized that treatment DHA would reduce expression proinflammatory genes aromatase, rate-limiting enzyme estrogen biosynthesis, in benign tissue overweight/obese women. A randomized, placebo-controlled, double-blind phase II study given 12...
The authors examined policies and practices related to adoption by gay lesbian parents in North Carolina. In this article, they review the literature concerning changing definition of family impact sexual orientation on development children relevant federal state legislation policy Workers a sample 20 100 county Departments Social Service were interviewed. results show that lack clear at or level protection from discrimination made it difficult for prospective adoptive adopt.
Abstract Agents that can reduce the incidence of hormone receptor negative breast cancer are currently lacking. Rexinoids such as bexarotene significantly reduced mammary tumor development in preclinical mouse models. Oral BRCA mutation carriers decreased cyclin D1 cells, suggesting biological activity on tissue. This study evaluated topical 1% gel applied to one unaffected women at high risk for 4 weeks assess safety and toxicity. Secondary objectives included assessment concentrations...
<div>Abstract<p>Obesity, a cause of subclinical inflammation, is risk factor for the development postmenopausal breast cancer and associated with poorer outcomes. Docosahexaenoic acid (DHA), an omega-3 fatty acid, possesses anti-inflammatory properties. We hypothesized that treatment DHA would reduce expression proinflammatory genes aromatase, rate-limiting enzyme estrogen biosynthesis, in benign tissue overweight/obese women. A randomized, placebo-controlled, double-blind phase...
<div>Abstract<p>Obesity, a cause of subclinical inflammation, is risk factor for the development postmenopausal breast cancer and associated with poorer outcomes. Docosahexaenoic acid (DHA), an omega-3 fatty acid, possesses anti-inflammatory properties. We hypothesized that treatment DHA would reduce expression proinflammatory genes aromatase, rate-limiting enzyme estrogen biosynthesis, in benign tissue overweight/obese women. A randomized, placebo-controlled, double-blind phase...
<div>Abstract<p>Agents that can reduce the incidence of hormone receptor negative breast cancer are currently lacking. Rexinoids such as bexarotene significantly reduced mammary tumor development in preclinical mouse models. Oral BRCA mutation carriers decreased cyclin D1 cells, suggesting biological activity on tissue. This study evaluated topical 1% gel applied to one unaffected women at high risk for 4 weeks assess safety and toxicity. Secondary objectives included assessment...
<div>Abstract<p>Agents that can reduce the incidence of hormone receptor negative breast cancer are currently lacking. Rexinoids such as bexarotene significantly reduced mammary tumor development in preclinical mouse models. Oral BRCA mutation carriers decreased cyclin D1 cells, suggesting biological activity on tissue. This study evaluated topical 1% gel applied to one unaffected women at high risk for 4 weeks assess safety and toxicity. Secondary objectives included assessment...
Abstract Background: Tamoxifen uptake for risk reduction has remained low due to concerns about toxicity despite the efficacy and effectiveness data available. Studies of tamoxifen in adjuvant preventive setting have demonstrated that a decline mammographic density (MD) approximately 10% is consistently associated with better outcomes. Additionally, MD one strongest independent predictors breast cancer risk, apart from older age BRCA1/2 mutation, among women. 4-hydroxytamoxifen topical gel...