A5084916598- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Adenosine and Purinergic Signaling
- Phagocytosis and Immune Regulation
- Adolescent and Pediatric Healthcare
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Advanced NMR Techniques and Applications
- Advanced MRI Techniques and Applications
- CAR-T cell therapy research
- Gut microbiota and health
- Cancer Research and Treatments
- Psoriasis: Treatment and Pathogenesis
- RNA modifications and cancer
- Cancer Cells and Metastasis
- RNA regulation and disease
- Dietary Effects on Health
- Atomic and Subatomic Physics Research
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Cytokine Signaling Pathways and Interactions
- Head and Neck Cancer Studies
- NMR spectroscopy and applications
- interferon and immune responses
- Ultrasound and Hyperthermia Applications
The University of Texas MD Anderson Cancer Center
2020-2024
Abstract The microenvironment that surrounds pancreatic ductal adenocarcinoma (PDAC) is profoundly desmoplastic and immunosuppressive. Understanding triggers of immunosuppression during the process tumorigenesis would aid in establishing targets for effective prevention therapy. Here, we interrogated differential molecular mechanisms dependent on cell origin subtype promote PDAC initiation established tumors. Transcriptomic analysis cell-of-origin–dependent epithelial gene signatures...
Abstract IL17 is required for the initiation and progression of pancreatic cancer, particularly in context inflammation, as previously shown by genetic pharmacological approaches. However, cellular compartment downstream molecular mediators IL17-mediated tumorigenesis have not been fully identified. This study examined generating transgenic animals with receptor A (IL17RA), which was genetically deleted from either epithelial or hematopoietic via generation IL17RA-deficient (IL17-RA−/−) bone...
There is an unmet need for the early diagnosis of pancreatic cancer. Diagnosis difficult due to asymptomatic nature One way detect stages monitor altered metabolism in premalignant lesions vivo with hyperpolarized metabolic imaging. Here we demonstrate how genetically engineered mouse models were used cancer as see increase compared control mice. Simultaneously observe changes hypoxia levels these using electron paramagnetic resonance
<div>Abstract<p>IL17 is required for the initiation and progression of pancreatic cancer, particularly in context inflammation, as previously shown by genetic pharmacological approaches. However, cellular compartment downstream molecular mediators IL17-mediated tumorigenesis have not been fully identified. This study examined generating transgenic animals with IL17 receptor A (IL17RA), which was genetically deleted from either epithelial or hematopoietic via generation...
<p>Supplementary Figure 8: IL/IL17-A signaling inhibits CD8 activation</p>
<p>Supplementary Figure 3. IL-17RA deletion results in an increase apoptosis, but not proliferation at 30 week time point.</p>
<p>Supplementary Figure 3. IL-17RA deletion results in an increase apoptosis, but not proliferation at 30 week time point.</p>
<p>Supplementary Figure 8: IL/IL17-A signaling inhibits CD8 activation</p>
<p>Supplementary Figure 2. IL-17RA in the pancreatic immune compartment is not required for tumorigenesis.</p>
<p>Supplementary Figure 9: Eomes expression, but not other markers of T-cell Exhaustion, are decreased in KC;IL-17RA fl/fl mice relative to KC mice</p>
Abstract Introduction: The high mortality rate of pancreatic cancer (PC) results from a lack methods for early detection. progression PC occurs primarily via two precursor pathways, either through microscopic intraepithelial neoplasias (PanINs) or macroscopic cystic lesions, which intraductal papillary mucinous neoplasms (IPMNs) are the most common. PanIns IPMN to PC, provides an opportunity detection this lethal disease. cells have extensively reprogrammed metabolism and we successfully...
Abstract Introduction: Pancreatic cancer is difficult to diagnose due its asymptomatic presentation at early stages. Therefore, there an unmet need for non-invasive imaging markers that can help identify the aggressive pancreatic lesions time point. One of most promising biomarkers conversion hyperpolarized (HP) pyruvate lactate1-3. With HP metabolic imaging, will be monitored among different premalignant models timepoints as well tested against pancreatitis, a known confounder in clinic....
Abstract Pancreatic ductal adenocarcinoma (PDAC) has become the third leading cause of cancer-related death in United States with high resistance to therapies, presentation at late stages and aggressive biology. Immunotherapy revolutionized cancer therapy by offering survival benefit many solid malignancies, however, it is still not effective pancreatic cancer. Host factors are crucial modulators responses immunotherapy. The roles gut microbiome modulating immune system determining outcomes...
<p>Supplementary Figure 7: Identification of IL-17-producing cell types</p>
<p>Supplementary Figure 11: B7-H4 is involved in PanINs progression</p>
<p>Supplementary Figure 10: IL-17 directly stabilizes B7-H4 mRNA</p>
<p>Supplementary Figure 6: Stemness signature in pancreatic epithelial cells lacking IL-17RA.</p>
<p>Supplementary Figure 5. IL-17/IL-17RA pancreatic epithelial signaling reshapes the tumor microenvironment.</p>
<p>Supplementary Figure 2. IL-17RA in the pancreatic immune compartment is not required for tumorigenesis.</p>
<p>Supplementary Figure 4. Immunoprofiling of KC mice receiving Wild-Type (WT) Bone Marrow (BM) or from IL-17RA Knock-Out (KO) Mice.</p>
<p>Supplementary Figure 11: B7-H4 is involved in PanINs progression</p>