A5053367421- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Extracellular vesicles in disease
- Gut microbiota and health
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Pancreatitis Pathology and Treatment
- Nanoplatforms for cancer theranostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Psoriasis: Treatment and Pathogenesis
- Maternal and Perinatal Health Interventions
- Childhood Cancer Survivors' Quality of Life
- T-cell and B-cell Immunology
- Genital Health and Disease
- Lymphadenopathy Diagnosis and Analysis
- Autoimmune and Inflammatory Disorders Research
- Oral microbiology and periodontitis research
- Ectopic Pregnancy Diagnosis and Management
The University of Texas MD Anderson Cancer Center
2018-2024
Zeynep Kamil Hospital
2016
Women’s Health Care
2016
Sakarya University
2015
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with an immunosuppressive microenvironment that is resistant to most therapies. IL17 involved in pancreatic tumorigenesis, but its role invasive PDAC undetermined. We hypothesized triggers and sustains immunosuppression. inhibited IL17/IL17RA signaling using pharmacological genetic strategies alongside mass cytometry multiplex immunofluorescence techniques. uncovered recruits neutrophils, neutrophil extracellular traps...
BackgroundCirculating miRNAs are known to play important roles in intercellular communication. However, the effects of exosomal on cells not fully understood.MethodsTo investigate role miR-1246 ovarian cancer (OC) microenvironment, we performed RPPA as well many other vitro functional assays (sensitive; HeyA8, Skov3ip1, A2780 and chemoresistant; HeyA8-MDR, Skov3-TR, A2780-CP20). Therapeutic effect inhibitor treatment was tested OC animal model. We showed uptake macrophages by co-culture...
Recent studies defined a potentially important role of the microbiome in modulating pancreatic ductal adenocarcinoma (PDAC) and responses to therapies. We hypothesized that antibiotic usage may predict outcomes patients with PDAC. retrospectively analyzed clinical data resectable or metastatic PDAC seen at MD Anderson Cancer from 2003 2017. Demographic, chemotherapy regimen use, duration, type, reason for indication were recorded. A total 580 studied, 342 resected 238 patients, selected our...
To investigate the effects of a land-based home exercise programme on pain, functional ability and quality life in patients with juvenile idiopathic arthritis.A randomized, controlled, single-blind study.Eighty-one arthritis participated this study.Functional ability, were assessed 6-minute walk test, Childhood Health Assessment Questionnaire, visual analogue scale, Pediatric Quality Life Inventory. The randomly assigned to an or control group. group (n = 43) completed 12-week individually...
Abstract Ten percent of pancreatic neuroendocrine tumors (pNET) are related to inherited syndromes (MEN1, MEN4, VHL, NF1, and TSC). Growing evidence suggests that clinically sporadic pNETs can also harbor germline pathogenic variants. In this study, we report the prevalence pathologic/likely pathologic (P/LP) variants in a high-risk cohort an unselected cohort. We collected clinical data patients with seen at MD Anderson Cancer Center Johns Hopkins Hospital. The included (n = 132) who...
ABSTRACT Background and Objectives Pancreatic cancer (PC) is the third cause of cancer-related deaths. Early detection interception premalignant pancreatic lesions represent a promising strategy to improve outcomes. We evaluated risk factors focal (FPLs) in asymptomatic individuals at hereditary high for PC. Methods This an observational single-institution cohort study conducted over period 5 years. Surveillance was performed through imaging studies (EUS or magnetic resonance...
Introduction The tumor microbiome (TM) has been linked to pancreatic cancer prognosis. Specific microbes can confer resistance therapies. Early knowledge of the TM at time diagnosis would be clinically relevant for precision therapy based on microbial composition. However, it is difficult define prior surgical resection. Methods In this pilot feasibility study, patients underwent Endoscopic Ultrasound-Fine Needle Aspiration (EUS-FNA) biopsy adenocarcinoma. These samples were analyzed using...
691 Background: Pancreatic cancer (PC) is the third leading cause of death in United States. The high mortality associated with PC attributed to multiple reasons: lack effective therapies, aggressive biology and late diagnosis. Due absence reliable early disease biomarkers, screening largely dependent on imaging. Recent studies have highlighted importance gut tumor microbiome PC. We present here first report oral prospective analysis high-risk individuals (PC-HRI) undergoing screening....
Objectives: The aim of the study was to assess effect 1 g ampicillin prophylactic dosage whether it is as effective 2 prevent maternal and neonatal morbidity in a randomized manner. Materials methods: One hundred fourty eight singleton pregnant women with preterm premature rupture membranes between 21 33 weeks gestation were followed-up during period our institution. We compared efficacy two different dosages ampicillin. population into groups. In group 1, intravenous given every 6 hours....
Circulating miRNAs are known to play important roles in intercellular communication.However, the effects of exosomal on cells not fully understood. In this study, substantial expression oncogenic miR-1246 sensitive as well chemoresistant (paclitaxel and multidrug) ovarian cancer (OC) exosomes was found. We showed that Cav1 gene, which is direct target miR-1246, involved process transfer. A significantly worse overall prognosis were found for OC patients with high low based TCGA data. higher...
<div>Abstract<p>Ten percent of pancreatic neuroendocrine tumors (pNET) are related to inherited syndromes (<i>MEN1</i>, <i>MEN4</i>, <i>VHL</i>, <i>NF1</i>, and <i>TSC</i>). Growing evidence suggests that clinically sporadic pNETs can also harbor germline pathogenic variants. In this study, we report the prevalence pathologic/likely pathologic (P/LP) variants in a high-risk cohort an unselected cohort. We collected...
<div>Abstract<p>Ten percent of pancreatic neuroendocrine tumors (pNET) are related to inherited syndromes (<i>MEN1</i>, <i>MEN4</i>, <i>VHL</i>, <i>NF1</i>, and <i>TSC</i>). Growing evidence suggests that clinically sporadic pNETs can also harbor germline pathogenic variants. In this study, we report the prevalence pathologic/likely pathologic (P/LP) variants in a high-risk cohort an unselected cohort. We collected...
<p>Supplementary Figure 1: Flow diagram showing the type of testing in both cohorts.</p>
<p>Supplementary Figure 1: Flow diagram showing the type of testing in both cohorts.</p>
Case PresentationA 23 years old woman referred to our medical center with diagnosis of retained placenta following vaginal delivery.On admission, ultrasound examination showed that the has covered right part uterus and there was no retroplacental clear zone.Multiple attempts were made at manual removal but we unable remove from uterus.Patient taken operating room for possible curettage under general anesthesia.All failed.The intraoperative exploration remained in uterine (Figure 1).According...