A5004550218- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Childhood Cancer Survivors' Quality of Life
- Cancer survivorship and care
- Melanoma and MAPK Pathways
- Sarcoma Diagnosis and Treatment
- Lymphatic System and Diseases
- Nutrition and Health in Aging
- Immune cells in cancer
- Telomeres, Telomerase, and Senescence
- Chemotherapy-induced cardiotoxicity and mitigation
- Neurobiology and Insect Physiology Research
- melanin and skin pigmentation
- Sphingolipid Metabolism and Signaling
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroblastoma Research and Treatments
- Adipose Tissue and Metabolism
- Frailty in Older Adults
- Hippo pathway signaling and YAP/TAZ
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Exercise and Physiological Responses
- Cancer Treatment and Pharmacology
- Diet and metabolism studies
- Pancreatic and Hepatic Oncology Research
The University of Texas MD Anderson Cancer Center
2016-2025
The University of Texas Health Science Center at Houston
2023
University of Pennsylvania
2013-2018
Cancer Research Institute
2013-2016
UPMC Hillman Cancer Center
2016
Sungkyunkwan University
2014
Institute of Immunology
2014
The University of Tokyo
2014
// Keri L. Schadler 1 , Nicholas J. Thomas Peter A. Galie 2 Dong Ha Bhang Kerry C. Roby Prince Addai Jacob E. Till Kathleen Sturgeon Alexander Zaslavsky Christopher S. Chen 3 Sandra Ryeom Department of Cancer Biology, Perelman School Medicine, University Pennsylvania, Abramson Family Research Institute, Philadelphia, PA 19104, USA Physiology, Bioengineering, Boston University, Boston, MA 02215, Correspondence to: Ryeom, email: sryeom@upenn.edu Keywords: tumor vascular normalization, NFAT,...
Maintenance of adult tissues depends on stem cell self-renewal in local niches. Spermatogonial cells (SSC) are germline necessary for spermatogenesis and fertility. We show that testicular endothelial (TECs) part the SSC niche producing glial line-derived neurotrophic factor (GDNF) other factors to support human mouse SSCs long-term culture. demonstrate FGF-2 binding FGFR1 TECs activates calcineurin pathway produce GDNF. Comparison TEC secretome lung liver identified 5 sufficient maintenance...
Purpose: To investigate relationships among physical activity, changes in function, and health-related quality of life (HRQOL) patients with pancreatic adenocarcinoma enrolled a home-based exercise prehabilitation program. Methods: Patients resectable receiving preoperative chemotherapy and/or chemoradiation were on this prospective, single-arm trial advised to perform ≥60 minutes each moderate-intensity aerobic strengthening weekly. Activity was measured via self-report accelerometers,...
Up to 85% of adult cancer survivors and 99% childhood live with an accumulation chronic conditions, frailty, and/or cognitive impairments resulting from its treatment. Thus, often show accelerated development multiple geriatric syndromes need therapeutic interventions. To advance progress in this area, the National Cancer Institute convened second 2 think tanks under auspices Accelerated Aging: Advancing Research for Healthy Survivors initiative. Experts assembled share evidence promising...
The premetastatic niche is a predetermined site of metastases, awaiting the influx tumor cells. However, regulation angiogenic switch at these sites has not been examined. Here, we demonstrate that calcineurin and nuclear factor activated T cells (NFAT) pathway specifically in lung endothelium prior to detection preferentially metastasize lung. Upregulation via deletion its endogenous inhibitor Dscr1 leads significant increase metastases due increased expression newly identified NFAT target,...
Abstract The efficacy of chemotherapy is reduced by dysfunctional tumor vasculature, which may limit delivery to tumors. Preclinical studies have shown that moderate aerobic exercise improves vascular function and increases in mouse models, but the effect on human vasculature has not yet been determined. Here, we demonstrate remodels accelerates regression, delays regrowth pancreatic ductal adenocarcinoma a patient-derived xenograft model treated with gemcitabine. By evaluating specimens...
Objective: To determine the effects of a preoperative, home-based exercise program on fitness and physical function in patients with pancreatic cancer. Background: We previously established well-tolerated preoperative after finding high frequency sarcopenia frailty Methods: In this randomized, controlled trial (NCT03187951), cancer were randomized to Arm A: enhanced usual care or B: prescribed aerobic resistance during neoadjuvant therapy. Patients received nutrition counseling activity...
ERK5 (extracellular signal-regulated kinase 5) is a dual transcription factor containing an N-terminal domain and C-terminal transcriptional activation domain. Many inhibitors have been developed tested to treat cancer inflammatory diseases. However, recent data raised questions about the role of catalytic activity in proliferation inflammation. We aimed investigate how reprograms myeloid cells proinflammatory senescent phenotype, subsequently leading atherosclerosis. A S496A...
Cardiotoxicity is a side effect for cancer patients treated with doxorubicin (DOX). We tested the hypothesis that low-intensity aerobic exercise concomitant DOX treatment would offset DOX-induced cardiotoxicity while also improving therapeutic efficacy of on tumor progression. B16F10 melanoma cells (3 × 10 5 ) were injected subcutaneously into scruff 6- to 8-wk-old male C57BL/6 mice ( n = 48). A 4 mg/kg cumulative dose was administered over 2 wk, and (EX) consisted treadmill walking (10...
Abstract Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration cytotoxic immune cells. The mechanisms driving these remain unclear. Herein, we demonstrate that exercise normalizes vasculature upregulates endothelial expression of VCAM1 in YUMMER 1.7 B16F10 murine models melanoma but differentially regulates growth, hypoxia, response. We found suppressed growth increased CD8+ T-cell not tumors. Single-cell RNA sequencing flow cytometry revealed...
We report the cardioprotective effects of moderate aerobic exercise from parallel pediatric murine models doxorubicin (Doxo) exposure in non–tumor-bearing immune competent (NTB-IC) mice and tumor-bearing nude (TB-NM). In both models, animals at 4 weeks age underwent Doxo treatment with or without 2 simultaneous exercise. sedentary NTB-IC TB-NM mice, resulted a statistically significant decrease ejection fraction fractional shortening compared control animals. Interestingly, during...
Abstract Recent studies in mouse models of cancer have shown that exercise improves tumor vascular function, thereby improving chemotherapy delivery and efficacy. However, the mechanisms underlying this improvement remain unclear effect on Ewing sarcoma (ES), a pediatric bone soft tissue cancer, is unknown. The hyperpermeability, which inversely correlates with drug to tumor, has also not been evaluated. We hypothesized efficacy by enhancing its through permeability. treated ES‐bearing mice...
Endoglin (ENG; CD105) is a coreceptor of the TGFβ family that highly expressed in proliferating endothelial cells. Often coopted by cancer cells, ENG can lead to neo-angiogenesis and vasculogenic mimicry aggressive malignancies. It exists both as transmembrane cell surface protein, where it primarily interacts with TGFβ, soluble matricellular protein (sENG) when cleaved matrix metalloproteinase 14 (MMP14). High expression has been associated poor prognosis Ewing sarcoma, an bone occurs...