A5078455132- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Esophageal Cancer Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Colorectal Cancer Treatments and Studies
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Pain Management and Opioid Use
- Economic and Financial Impacts of Cancer
- Gallbladder and Bile Duct Disorders
- Neuroblastoma Research and Treatments
- Enhanced Recovery After Surgery
- Colorectal Cancer Screening and Detection
- Anesthesia and Pain Management
- Opioid Use Disorder Treatment
The University of Texas MD Anderson Cancer Center
2016-2025
Burroughs Wellcome Fund
2024
Texas A&M University
2024
Yahoo (United Kingdom)
2023
Society of Surgical Oncology
2018-2023
Society for Surgery of the Alimentary Tract
2023
Gifu University
2022
Michael E. DeBakey VA Medical Center
2022
Baylor College of Medicine
2022
Cancer Institute (WIA)
2022
Fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) gemcitabine plus nanoparticle albumin-bound (nab)-paclitaxel (GA) are first-line chemotherapy regimens for pancreatic cancer. Their relative efficacy in the setting of localized disease is unknown.To evaluate radiographic serologic measures responses associated with FOLFIRINOX or GA, to determine association between these drug regimens, putative response, survival.This case series assessed 485 consecutive patients who were...
Objective: We sought to identify potential radiologic and serologic markers of pancreatic tumor response therapy, using pathologic major (pMR) as the objective endpoint. Background: previously demonstrated that a pMR preoperative defined detection <5% viable cancer cells in surgical specimen on histopathological analysis, is an important prognostic factor for patients with ductal adenocarcinoma (PDAC). Methods: Pretreatment posttreatment computed tomography scans consecutive who received...
Pancreatic ductal adenocarcinoma (PDAC) remains one of the leading causes cancer-related deaths in world. For patients with PDAC who are not eligible for surgery, radiation therapy improves local disease control, yet safely delivering therapeutic doses challenging due to off-target toxicities surrounding normal tissues. NBTXR3, a novel radioenhancer composed functionalized hafnium oxide crystalline nanoparticles, has recently shown clinical activity soft tissue sarcoma, hepatocellular...
Purpose After preoperative chemoradiotherapy followed by total mesorectal excision for locally advanced rectal cancer, patients who experience local or systemic relapse of disease may be eligible curative salvage surgery, but the benefit this surgery has not been fully investigated. The purpose study was to characterize recurrence patterns and investigate impact on survival in with cancer after receiving multidisciplinary treatment. Patients Methods (cT3-4 cN+) were treated at our...
In hepatocellular carcinoma (HCC), surgical resection is associated with high recurrence rate, and no effective adjuvant therapy currently exists. We initiated a pilot randomized trial of perioperative immunotherapy nivolumab ipilimumab for resectable HCC. Here, we provide an illustrative report case that achieved complete response immunologic correlates this pathologic to immunotherapy. Clinical was correlated increase in CD8+ T-cell infiltration, two effector clusters. This study ongoing,...
BACKGROUND No studies have investigated whether race/ethnicity is associated with the recommended use of preoperative chemotherapy or subsequent outcomes in gastric cancer. To determine there such an association, analyses patients cancer National Cancer Data Base (NCDB) were performed. METHODS Patients clinical T2‐4bN0‐1M0 adenocarcinoma, as defined by eighth edition American Joint Committee on staging manual, who underwent gastrectomy from 2006 to 2014 identified NCDB. Multiple logistic...
Objective: To determine the effects of a preoperative, home-based exercise program on fitness and physical function in patients with pancreatic cancer. Background: We previously established well-tolerated preoperative after finding high frequency sarcopenia frailty Methods: In this randomized, controlled trial (NCT03187951), cancer were randomized to Arm A: enhanced usual care or B: prescribed aerobic resistance during neoadjuvant therapy. Patients received nutrition counseling activity...
Objective: To characterize associations between carbohydrate antigen 19–9 (CA19–9) dynamics during neoadjuvant therapy (NT) and survival for patients with pancreatic ductal adenocarcinoma (PDAC). Background: Although normalization of CA19–9 NT is associated improved outcomes following PDAC resection, we hypothesize that can improve prognostication. Methods: Characteristics undergoing (July 2011–October 2018) ≥3 results (bilirubin<2mg/dL) were collected grouped by dynamics. Nonproducers...
BACKGROUNDPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with unpredictable responses to chemotherapy. Approaches assay patient tumors before treatment and identify effective regimens based on tumor sensitivities are lacking. We developed an organoid-based platform (OBP) visually quantify patient-derived organoid (PDO) drug treatments associated tumor-stroma modulation for personalized PDAC therapy.METHODSWe retrospectively quantified apoptotic cell...
As the number of older adults with gastric cancer requiring gastrectomy has increased, it become increasingly important to use techniques that enhance surgical safety and reduce postoperative complications in this vulnerable patient population. Articulating laparoscopic instruments (ALIs) may improve maneuverability precision, leading better outcomes patients. This study aimed compare undergoing distal for using conventional versus ALIs. retrospective included 147 patients (aged ≥70 years)...
Abstract Background The granular methods by which centers can safely implement and effectively expand robotic distal pancreatectomy (RDP), including those related to appropriate patient selection during the learning curve period, remain unclear. This study aimed verify that our strategic surgical oncology program implemented RDP as standard practice identify factors associated with prolonged operation time. Materials Methods We performed a detailed analysis of intraoperative short‐term...
Abstract Background Costs associated with robotic pancreatectomy compared to those of open are assumed be high but not well known, particularly during the initial implementation robot. Study Design Patients who underwent for any diagnosis from January 2017 August 2021 were identified retrospectively. Total hospital cost was calculated using intraoperative, inpatient, and outpatient costs within 30 days surgery. The ratio total each average all operations at our center used represent without...