A5019846091- Blood Coagulation and Thrombosis Mechanisms
- Angiogenesis and VEGF in Cancer
- Telomeres, Telomerase, and Senescence
- Ubiquitin and proteasome pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Venous Thromboembolism Diagnosis and Management
- PI3K/AKT/mTOR signaling in cancer
- Hippo pathway signaling and YAP/TAZ
- Cholesterol and Lipid Metabolism
- Protein Tyrosine Phosphatases
- Kruppel-like factors research
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Coronary Interventions and Diagnostics
- Elasticity and Material Modeling
- Ferroptosis and cancer prognosis
- Melanoma and MAPK Pathways
- Orthopedic Surgery and Rehabilitation
- Congenital limb and hand anomalies
- Protein Kinase Regulation and GTPase Signaling
- Pluripotent Stem Cells Research
- Lipoproteins and Cardiovascular Health
- Biomarkers in Disease Mechanisms
Houston Methodist
2018-2023
Cornell University
2022
Reaction Engineering International (United States)
2022
Día de la Mujer Latina
2022
Chiba University
2016-2021
Yale University
2010-2013
VA Connecticut Healthcare System
2011
ERK5 (extracellular signal-regulated kinase 5) is a dual transcription factor containing an N-terminal domain and C-terminal transcriptional activation domain. Many inhibitors have been developed tested to treat cancer inflammatory diseases. However, recent data raised questions about the role of catalytic activity in proliferation inflammation. We aimed investigate how reprograms myeloid cells proinflammatory senescent phenotype, subsequently leading atherosclerosis. A S496A...
The possible association between the membrane-associated guanylate kinase with inverted domain structure-1 (MAGI1) and inflammation has been suggested, but molecular mechanisms underlying this link, especially during atherogenesis, remain unclear. In endothelial cells (ECs) exposed to disturbed flow (d-flow), p90 ribosomal S6 (p90RSK) bound MAGI1, causing MAGI1-S741 phosphorylation sentrin/SUMO-specific protease 2 T368 phosphorylation-mediated MAGI1-K931 deSUMOylation. upregulated EC...
Ponatinib is a multi-targeted third generation tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukemia (CML) patients harboring Abelson (Abl)-breakpoint cluster region (Bcr) T315I mutation. In spite having superb clinical efficacy, ponatinib triggers severe vascular adverse events (VAEs) that significantly limit its therapeutic potential. On endothelial cells (ECs), promotes EC dysfunction and apoptosis, inhibits angiogenesis. Furthermore, ponatinib-mediated...
Tissue factor (TF) is expressed in atherosclerotic lesions. Since mechanical forces influence endothelial cell (EC) function and are thought to account for the unique distribution of atherosclerosis areas exposed disturbed flow, we hypothesized that to-fro flow (TFF) unidirectional pulsatile forward (PFF) would have different effects on TF expression EC. RNA HUVEC stress presence or absence chemical stimulation with thrombin was determined. TFF induced a significantly higher than PFF...
Previously, we reported that post-translational modifications (PTMs) of MAGI1, including S741 phosphorylation and K931 de-SUMOylation, both which are regulated by p90RSK activation, lead to endothelial cell (EC) activation. However, roles for MAGI1-PTMs in regulating EC permeability remain unclear despite MAGI1 being a junctional molecule. Here, show thrombin (Thb)-induced permeability, detected the electric cell-substrate impedance sensing (ECIS) based system, was decreased overexpression...
We hypothesized that polyphenols contained in olive oil play a role reducing the risk of atherosclerosis. The aim this study was to determine if oil, oleuropein (Ole), hydroxytyrosol (HT), and tyrosol (Tyr) could inhibit smooth muscle cell (SMC) proliferation through its influence on cycle regulation. Bovine vascular SMC were cultured presence Ole, HT, or Tyr at concentration 1, 10, 100 μmol/L. On days 3, 5, numbers cells counted. Cell analysis performed by flow cytometry day 1 after stained...
Background The deSUMOylase sentrin-specific isopeptidase 2 (SENP2) plays a crucial role in atheroprotection. However, the phosphorylation of SENP2 at T368 under disturbed flow (D-flow) conditions hinders its nuclear function and promotes endothelial cell (EC) activation. SUMOylation has been implicated D-flow-induced endothelial-to-mesenchymal transition (endoMT), but precise counteracting this process remains unclear. Method We developed phospho-specific S344 antibody generated knock-in...
Objective: Our knowledge of human neural crest stem cells (NCSCs) is expanding, owing to recent advances in technologies utilizing human-induced pluripotent (hiPSCs) that generate NCSCs. However, the clinical application these requires reduction xeno-materials. To overcome this significant impediment, study aimed devise a novel method induce NCSCs from hiPSCs without using feeder cell layer.
Hypothesis: No study has evaluated radiocapitellar joint alignment or proximal radioulnar postoperatively in congenital synostosis patients. The aim of this was to clarify the postoperative clinical results and alignment. Methods: Eight forearms 7 patients (6 males 1 female with a mean age 8.8 years) synostosis, who underwent surgery minimum year 2.1 years follow-up, were evaluated. consisted division interposition pedicled vascularized adipofascial flap between radius ulna. A corrective...