A5046297131- Plant Growth Enhancement Techniques
- Probiotics and Fermented Foods
- Angiogenesis and VEGF in Cancer
- Telomeres, Telomerase, and Senescence
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genomics and Phylogenetic Studies
- Microbial Natural Products and Biosynthesis
- interferon and immune responses
- Tryptophan and brain disorders
- Cancer, Hypoxia, and Metabolism
- Chemotherapy-induced cardiotoxicity and mitigation
- Plant biochemistry and biosynthesis
- Protease and Inhibitor Mechanisms
- Cardiac Health and Mental Health
- Layered Double Hydroxides Synthesis and Applications
- Bacteriophages and microbial interactions
- Biochemical and Structural Characterization
- Aquaculture disease management and microbiota
- Hippo pathway signaling and YAP/TAZ
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Chemokine receptors and signaling
- Mast cells and histamine
- Vibrio bacteria research studies
Houston Methodist
2022-2025
Cornell University
2024
Vietnam Academy of Science and Technology
2020-2023
RMIT University
2020-2023
Nha Trang University
2020
Antimicrobial peptides have the potential to be used in a range of applications, including as an alternative conventional antibiotics for treatment bacterial infections humans and animals. Therefore, there is interest identifying novel bacteriocins which desirable physico-chemical properties or antimicrobial activities. Paenibacillus polymyxa #23, isolated from marine sponge, has wide spectrum activity against Gram-negative Gram-positive bacteria. To explore basis this activity, complete...
k-Oligocarrageenan (OC) is an effective biostimulator and a protector against disease infections for plants. However, the effect of OC molecular weight (MW) on plant growth not fully understood. In this work, OCs with three different MWs (42, 17 4 kDa) was prepared by varying degradation reaction time using ascorbic acid as reagent. The product structure confirmed Fourier-transform infrared spectroscopy (FTIR) data. promotion maize (Zea mays L.) plants investigated foliar spray application...
Vibriosis in farmed animals is a serious threat to aquaculture worldwide. Using probiotics and anti-Vibrio antimicrobial substances systems can be means of preventing Vibrio infections. Therefore, we aimed characterize compare 16 potential (Vi+) isolated from marine sponges fish intestines collected the Vietnam Sea, as well an bacteriocin fully explore their application potentials. 16S rRNA sequencing confirmed all Vi+ Bacillus species with different strain variants across two sample types....
The widespread occurrence of pathogenic bacteria resistant to last-line antibiotics has resulted in significant challenges human and veterinary medicine. There is an urgent need for new antimicrobial agents that can be used control these life threating pathogens. We report the identification activities, against a broad range bacterial pathogens, from collection marine-derived spore-forming bacteria. Although marine environments have been previously investigated as sources novel antibiotics,...
Background The deSUMOylase sentrin-specific isopeptidase 2 (SENP2) plays a crucial role in atheroprotection. However, the phosphorylation of SENP2 at T368 under disturbed flow (D-flow) conditions hinders its nuclear function and promotes endothelial cell (EC) activation. SUMOylation has been implicated D-flow-induced endothelial-to-mesenchymal transition (endoMT), but precise counteracting this process remains unclear. Method We developed phospho-specific S344 antibody generated knock-in...
We have shown that membrane-associated guanylate kinase with inverted domain structure-1 (MAGI1), a scaffold protein six PSD95/DiscLarge/ZO-1 (PDZ) domains, is involved in the regulation of endothelial cell (EC) activation and atherogenesis mice. In addition to causing acute respiratory disease, influenza A virus (IAV) infection plays an important role triggers coronary syndromes fatal myocardial infarction. Therefore, aim this study investigate function MAGI1 IAV-induced EC activation....
Background Traf2 and Nck-interacting kinase (TNIK) is known for its regulatory role in various processes within cancer cells. However, endothelial cells (ECs) has remained relatively unexplored. Methods Leveraging RNA-seq data Ingenuity Pathway Analysis (IPA), we probed the potential impact of TNIK depletion on ECs. Results Examination uncovered more than 450 Differentially Expressed Genes (DEGs) TNIK-depleted ECs, displaying a fold change exceeding 2 with false discovery rate (FDR) below...
Background: Atherosclerotic plaques, especially high-risk ones, form in blood vessel regions exposed to d-flow. EC dysfunction induced by d-flow likely contributes plaque development. In contrast, with laminar flow (l-flow) are less susceptible formation. Although the Hippo pathway is implicated mechano-transduction, exact role and molecular mechanisms of LATS1/2 response remain incompletely understood. Methods: We employed endothelial cell (EC)-specific Lats1 Lats2 knockout mice within a...
Background: While the shelterin complex, including TERF2IP, is established in its role of telomere protection, interaction with Hippo pathway, which also regulates senescence and inflammation, has not been reported. Our research aims to investigate whether TERF2IP influences potentially linking it endothelial cell (EC) responses under disturbed flow (d-flow). Methods: ECs were transduced variants, subjected d-flow or static conditions. Post-transfection makron-1 ubiquitin E3 ligase...
Background: D-flow’s impact on metabolic reprogramming, particularly glycolysis, needs reevaluation due to its conflicting role in atherosclerosis. We show that d-flow reduces LATS1/2 expression, leading both EC proliferation and senescence. However, the exact molecular mechanisms remain elusive. Methods: utilized EC-specific Lats1 +/- /Lats2 -/- knockout (LATS1/2-EKO) mice a partial left carotid ligation (PLCL) model under hypercholesterolemia with AAV-PCSK9 injection mimic d-flow....
Background: Atherogenesis often develops in regions with disturbed blood flow (d-flow), involving increased ERK5 and p53 SUMOylation due to SENP2 T368 phosphorylation, leading SUMOylation, contributing endothelial cell (EC) activation. Conversely, laminar (l-flow) induces S344 reducing thereby suppressing EC The presence of senescent ECs atherosclerotic plaques suggests that d-flow-induced senescence may contribute atherogenesis, possibly metabolic changes. glycolysis is crucial for NO...
The goal of this study: Telomeric repeat-binding factor 2 (TRF2) interacting protein 1 (TERF2IP) not only associates with TRF2 to protect telomeres but also RSK promote senescence. later has been detected in endothelial cells (ECs) under disturbed flow (DF), which involved TERF2IP S205 phosphorylation. Besides, it suggested that K240 can be SUMOylated; however, its role senescence and atherogenesis remains unknown. Methods: We investigated the functional SUMOylation utilizing a model...
Aims: To investigate the role of Checkpoint Kinase 1 (CHK1)-associated SENP2 S344 phosphorylation in laminar flow (LF)-regulated Endothelial-Mesenchymal Transition (EndMT) inhibition and underlying mechanisms. Methods: We generated deSUMOylation enzyme sentrin-specific isopeptidase 2 (SENP2) S343A (equivalent to human S344) knock-in (KI) endothelial cell (EC)-specific knock-out (SENP2 EKO) mice detect EC activation, EndMT, atherogenesis vitro vivo . also performed next-generation RNA...