The origin of Ewing's sarcoma is a subject much debate. Once thought to be derived from primitive neuroectodermal cells, many now believe it arise mesenchymal stem cell (MSC). Expression the EWS-FLI1 fusion gene in MSCs changes morphology resemble and induces expression markers. In murine transformation sarcomas can occur. knockdown experiments, cells develop characteristics ability differentiate into mesodermal lineages. However, cannot concluded that are origin. concept an MSC still needs...

High levels of the critical p53 inhibitor Mdm4 is common in tumors that retain a wild-type allele, suggesting overexpression an important mechanism for inactivation during tumorigenesis. To test this hypothesis vivo, we generated transgenic mice with widespread expression Mdm4. Two independent lines mice, Mdm4(Tg1) and Mdm4(Tg15), developed spontaneous tumors, most prevalent which were sarcomas. determine whether also cooperated heterozygosity to induce tumorigenesis, p53(+/-) mice. These...

Abstract Background Given the poor outcomes of influenza-associated pulmonary aspergillosis (IAPA), there is a major unmet need for innovative therapeutic strategies. Impairment pathogen recognition receptor (PRR) signaling known pathomechanism and prognostic factor in IAPA patients. Therefore, we performed immunotherapy with nebulized PRR agonists murine model studied its impact on infection immunopathology. Timeline experimental interventions. Abbreviations: AF = Aspergillus fumigatus, CA...

Mitochondria are key regulators in cell proliferation and apoptosis. Alterations mitochondrial function closely associated with inflammation tumorigenesis. This study aimed to investigate whether transcription factor A (TFAM), a regulator of DNA replication, is involved the initiation progression colitis-associated cancer (CAC).TFAM expression was examined tissue samples inflammatory bowel diseases (IBD) CAC by immunohistochemistry. Intestinal epithelial (IEC)-specific TFAM-knockout mice...

An atmospheric-pressure N2–Ar plasma is investigated by means of optical emission spectroscopic diagnosis concerning the variation its fundamental parameters, electron density and temperature, concentrations ionized molecular nitrogen, atomic excited argon with tuning variables, such as input power ratio N2 in mixture gas, discharge region torch. Moreover, qualitative discussions are delivered respect to mechanisms for nitrogen dissociation influence Ar component on at atmospheric pressure.

Hyperosmolality-gated calcium-permeable channels (OSCA) are Ca 2 + nonselective cation that contain the calcium-dependent DUF221 domain, which plays an important role in plant response to stress and growth. However, OSCA gene has not been fully identified analyzed sunflowers. In this study, we comprehensively number, structure, collinearity, phylogeny of family sunflower, six Compositae species ( Arctium lappa, Chrysanthemum morifolium, Cichorium endivia, intybus, Lactuca sativa var....

Power grid fault diagnosis methods based on analytical models possess advantages such as logical rigor, strong interpretability, and high applicability. However, the existing design of their objective functions is presented a 0-1 integer nonlinear programming model, making it difficult to approximate optimal solution. To address this issue, paper proposes an improvement expression second backup protection expectation involved in diagnostic model. Thus, order function successfully reduced,...

In high power AC speed regulation systems, frequency of inverter is wide and switching limited. this paper, the PWM strategy for vector control induction motor in medium voltage introduced. Asynchronous modulation multi-step synchronous modulations are concluded strategy. modulations, selective harmonic elimination (SHEPWM) employed because low frequency. The factors impacting smooth transition between different modes analyzed. corresponding solutions put forward. And these methods verified...

The electromagnetic repulsion actuator is a novel high-speed one based on the principle of eddy current. Its driving equipment mainly composed coils and dish. main characteristics are short energizing time, high speed movement ability that can drive switch to cut off faults in power grid within very time. In this paper, an improved repulsive force driver proposed, which realizes motion energy conservation by cooperating with permanent magnet holding device. has simple structure, open/close...

Arc determines whether the vacuum switchgears can break current successfully, so it is significant to study its characteristics. In this paper, a hybrid high-speed actuator was designed, and method of forced zero used interrupt dc in synthetic test circuit. With different contact opening speeds, processes arc burning transferring were observed by CMOS camera. Through area obtained an image processing technology, influences speed on researched, including initial stage, at same electrode...

With the demands of propulsion systems, medium voltage high power AC drives are required. In drives, switch frequency devices has to be limited in order reduce loss semiconductor devices, torque ripple and electromagnetic interference. this paper, a proposed drive control system with selective harmonic elimination PWM (SHEPWM) for induction motor is presented. Designed based on rotor-field oriented vector employed strategy which holds four different modulations. SHEPWM principle introduced....

For phase-controlled vacuum breakers, the acting time of actuator should be precise. The variation capacitor voltage, capacitance, and environmental temperature impact dispersion closing seriously. A new technology has been put forward in this paper. It is speed control breaker. This can used for operation breakers. By using technology, deviation displacement corrected real time. So permanent-magnetic (PMA) move along with given curve. Also, stable when external factors, such as environment...

This paper introduces selective harmonic elimination PWM (SHEPWM) technology applied in PMSMs. According to model of PMSMs, relation between currents and voltages is derived. From this relation, selection principle SHEPWM different for salient pole PMSMs non-salient Besides, the method smooth transition SHEPWMs introduced. Simulations experiments have been completed test those conclusions correctness.

Influenza-associated pulmonary aspergillosis (IAPA) is a feared complication in patients with influenza tracheobronchitis, especially those receiving corticosteroids. Herein, we established novel IAPA mouse model low-inoculum Aspergillus infection and compared outcomes mice without cortisone acetate (CA) immunosuppression. CA was an independent predictor of increased morbidity/mortality IAPA. Early antifungal treatment liposomal amphotericin B pivotal to improve CA-immunosuppressed mice,...

Background: A series of studies have demonstrated that NPAS2 plays a critical role in the development and progression several cancers. However, association between genetic variants gene clinical outcome patients with non-small-cell lung cancer (NSCLC) has not been investigated. Methods: Six functional SNPs were selected genotyped using Sequenom iPLEX genotyping system cohort 484 Chinese NSCLC undergoing surgery. Multivariate Cox proportional hazards model used for prognosis analysis....

A developed atmospheric-pressure capacitive discharge source driven by radio-frequency power supply at 13.56 MHz is capable of producing a homogeneous and cold glow in N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Ar. The measurements its electrical parameters are made systematically with respect to the nitrogen component when diluted into argon plasma various concentration ratio, variation tendencies atomic <inline-formula...

Here, a DC vacuum arc interruption test based on the hybrid high-speed actuator and method of commutation is carried out in synthetic loop system. The safe stroke one basic breaking parameters. minimum directly determines time property mechanical circuit breaker. main breaker switch driven by electromagnetic repulsion actuator. In order to simplify its control system, also adopts switch. current source for verification this system provided LC oscillator with lower frequency. Simulations some...

To ensure the reliability of power supply, a dual supply structure appears in distribution system. Power switching is complex physical process. This paper presents novel model electromechanical contactors. can simulate multi-physics process switching. article completes simulation framework for through contactors first time. Among them, structural topology also proposed. On basis topology, an equivalent magnetic circuit established to calculate relationship between driving force, flux...

Impedance matching is implemented to stabilize an atmospheric-pressure waveguide-based N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -Ar plasma torch with the aid of use swirl gas. Optical emission spectroscopy employed diagnose respect population electronic state <sup xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> (B xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> Σ xmlns:xlink="http://www.w3.org/1999/xlink">u</sub> ) and...