A5089552735- Chemotherapy-induced cardiotoxicity and mitigation
- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- PARP inhibition in cancer therapy
- Cancer Treatment and Pharmacology
- DNA Repair Mechanisms
- Cancer therapeutics and mechanisms
- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- Cardiac Fibrosis and Remodeling
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Synthesis and Biological Activity
- Peptidase Inhibition and Analysis
- Cancer survivorship and care
- Electron Spin Resonance Studies
- Cardiovascular Effects of Exercise
- Global Cancer Incidence and Screening
- Urological Disorders and Treatments
- Congenital heart defects research
- Family Support in Illness
- RNA modifications and cancer
- Quinazolinone synthesis and applications
- Kruppel-like factors research
- Kawasaki Disease and Coronary Complications
The University of Texas Health Science Center at Houston
2018-2024
The University of Texas Health Science Center at San Antonio
2013-2023
Children's Cancer Center
2017-2023
The University of Texas at San Antonio
2023
Cancer Research Center
2018
St. Jude Children's Research Hospital
2018
Cancer Research Institute of the Slovak Academy of Sciences
2018
Urology San Antonio
2018
City of Hope
2018
Center for Cancer Research
2002-2008
DNA double-strand breaks originating from diverse causes in eukaryotic cells are accompanied by the formation of phosphorylated H2AX (γH2AX) foci. Here we show that γH2AX is also a cellular response to topoisomerase I cleavage complexes known induce during replication. In HCT116 human carcinoma exposed inhibitor camptothecin, resulting can be prevented with phosphatidylinositol 3-OH kinase-related kinase wortmannin; however, contrast ionizing radiation, only camptothecin-induced replication...
Anthracyclines are part of many effective pediatric cancer treatment protocols. Most oncology groups assume that the hematologic toxicity anthracycline agents is equivalent to their cardiotoxicity; for example, Children's Oncology Group substitution rules consider daunorubicin and epirubicin isoequivalent doxorubicin, whereas mitoxantrone idarubicin considered 4 5 times as toxic doxorubicin.
SARS-CoV-2 is a newly identified coronavirus that causes the respiratory disease called 2019 (COVID-19). With an urgent need for therapeutics, we lack full understanding of molecular basis SARS-CoV-2-induced cellular damage and progression. Here, conducted transcriptomic analysis human PBMCs, significant changes in mitochondrial, ion channel, protein quality-control gene products. proteins selectively target organelle compartments, including endoplasmic reticulum mitochondria. M-protein,...
Data-driven basic, translational, and clinical research has resulted in improved outcomes for children, adolescents, young adults (AYAs) with pediatric cancers. However, challenges sharing data between institutions, particularly research, prevent addressing substantial unmet needs children AYA patients diagnosed certain Systematically collecting from every child can enable greater understanding of cancers, improve survivorship, accelerate development new more effective therapies. To...
Summary Kawasaki disease (KD) vasculitis is an acute febrile illness of childhood characterized by systemic unknown origin, and the most common cause acquired heart among children in United States. While histological evidence myocarditis can be found all patients with KD, only a minority are clinically symptomatic subset demonstrate echocardiographic impaired myocardial function, as well increased left ventricular mass, presumed to due edema inflammation. Up third KD fail respond first-line...
We report the cardioprotective effects of moderate aerobic exercise from parallel pediatric murine models doxorubicin (Doxo) exposure in non–tumor-bearing immune competent (NTB-IC) mice and tumor-bearing nude (TB-NM). In both models, animals at 4 weeks age underwent Doxo treatment with or without 2 simultaneous exercise. sedentary NTB-IC TB-NM mice, resulted a statistically significant decrease ejection fraction fractional shortening compared control animals. Interestingly, during...
Anthracyclines are the critical component in a majority of pediatric chemotherapy regimens due to their broad anticancer efficacy. Unfortunately, vast long-term childhood cancer survivors will develop chronic health condition caused by successful treatments and severe cardiac disease is common life-threatening outcome that unequivocally linked previous anthracycline exposure. The intricacies how anthracyclines such as doxorubicin, damage heart initiate process progresses over multiple...
Abstract Purpose: Ecteinascidin 743 (Et743; trabectedin, Yondelis) has recently been approved in Europe for the treatment of soft tissue sarcomas and is undergoing clinical trials other solid tumors. Et743 selectively targets cells proficient TC-NER, which sets it apart from DNA alkylating agents. In present study, we examined effects on RNA Pol II. Experimental Design Results: We report that induces rapid massive degradation transcribing II various cancer cell lines normal fibroblasts. was...
Negative elongation factor (NELF) is known to enforce promoter-proximal pausing of RNA polymerase II (Pol II), a pervasive phenomenon observed across multicellular genomes. However, the physiological impact NELF on tissue homeostasis remains unclear. Here, we show that whole-body conditional deletion B subunit (NELF-B) in adult mice results cardiomyopathy and impaired response cardiac stress. Tissue-specific knockout NELF-B confirms its cell-autonomous function cardiomyocytes. directly...
Echocardiography is a robust tool for assessing cardiac function in both humans and laboratory animals. Conventional echocardiographic measurements, including chamber dimensions, wall thickness, ejection fraction are routinely obtained to assess mice. Recently, myocardial strain rate measurements have been added functional assessments provide additional details on regional abnormalities that not evident using conventional measurements. To date, all studies of mice or rats involved adult This...
As a result of their treatment, childhood cancer survivors face an increased risk acute and chronic heart failure. Epidemiological studies have shown the anticancer drug doxorubicin, while effective, to be cardiotoxic. Patients suffering from doxorubicin cardiotoxicity exhibit interstitial fibrosis, one component This project aims elucidate mechanism fibrosis in doxorubicin‐induced failure by examining changes transforming growth factor‐beta (TGF‐β) signaling pathway after exposure...
Abstract Background 25% of all breast cancer patients have HER-2 overexpression. Breast Cancer with overexpression are typically treated inhibitors such as Trastuzumab. Trastuzumab is known to cause a decrease in left ventricular ejection fraction. The aim this study create cardiac risk prediction tool among women Her-2 positive predict cardiotoxicity. Method Using split sample design, we created using patient level data from electronic medical records. included 18 years age and older...
Neighborhood socioeconomic deprivation has been linked to adverse health outcomes, yet it is unclear whether neighborhood-level social determinants of (SDOH) measures affect overall survival in adolescent and young adult patients with cancer.
An X Chromosome Gene, WTX, Is Commonly Inactivated in Wilms Tumor. Rivera MN, Kim WJ, Wells J, et al. Science. 2007;315:642–645Current Therapy for Metzger ML, Dome JS. Oncogene. 2005;10:815–826Renal Tumors. JS, Perlman EJ, Ritchey Coppes MJ, Kalapurakal Grundy PE. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. 5th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2006:905–932In 1899, surgeon Max published a report seven children suffering from malignant...
Abstract Cardiac non-myocytes comprise a diverse and crucial cell population in the heart that plays dynamic roles cardiac wound healing growth. Non-myocytes broadly fall into four types: endothelium, fibroblasts, leukocytes, pericytes. Here we characterize diversity of vivo vitro using mass cytometry. By leveraging single-cell RNA sequencing inform design cytometry panel. To aid annotation datasets, utilize data integration with neural network. We introduce approximately 460,000∼ single...