A5058026911- Melanoma and MAPK Pathways
- melanin and skin pigmentation
- Neurobiology and Insect Physiology Research
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Exercise and Physiological Responses
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Computational Drug Discovery Methods
- Autophagy in Disease and Therapy
- Single-cell and spatial transcriptomics
University of Chicago
2025
The University of Texas MD Anderson Cancer Center
2023
Abstract Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration cytotoxic immune cells. The mechanisms driving these remain unclear. Herein, we demonstrate that exercise normalizes vasculature upregulates endothelial expression of VCAM1 in YUMMER 1.7 B16F10 murine models melanoma but differentially regulates growth, hypoxia, response. We found suppressed growth increased CD8+ T-cell not tumors. Single-cell RNA sequencing flow cytometry revealed...
Nutrient limitation is a characteristic feature of poorly perfused tumors. In contrast to well-perfused tissues, nutrient deficits in tumors perturb cellular metabolic activity, which imposes constraints on cancer cells. The created by the tumor microenvironment can lead vulnerabilities cancers. Identifying and that arise cancers provide new insight into biology identify promising antineoplastic targets. To how constrains metabolism pancreatic tumors, we challenged cells with...
<div>Abstract<p>Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration cytotoxic immune cells. The mechanisms driving these remain unclear. Herein, we demonstrate that exercise normalizes vasculature upregulates endothelial expression of VCAM1 in YUMMER 1.7 B16F10 murine models melanoma but differentially regulates growth, hypoxia, response. We found suppressed growth increased CD8+ T-cell not tumors. Single-cell RNA sequencing flow...
<p>Supplementary Figures S1-S8</p>
<p>Supplementary Figures S1-S8</p>
<div>Abstract<p>Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration cytotoxic immune cells. The mechanisms driving these remain unclear. Herein, we demonstrate that exercise normalizes vasculature upregulates endothelial expression of VCAM1 in YUMMER 1.7 B16F10 murine models melanoma but differentially regulates growth, hypoxia, response. We found suppressed growth increased CD8+ T-cell not tumors. Single-cell RNA sequencing flow...
<p>Supplementary Figures S1-S8</p>
<div>Abstract<p>Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration cytotoxic immune cells. The mechanisms driving these remain unclear. Herein, we demonstrate that exercise normalizes vasculature upregulates endothelial expression of VCAM1 in YUMMER 1.7 B16F10 murine models melanoma but differentially regulates growth, hypoxia, response. We found suppressed growth increased CD8<sup>+</sup> T-cell not tumors. Single-cell...
<p>Supplementary Figures S1-S8</p>
<p>Supplementary Figures S1-S8</p>
<p>Supplementary Figures S1-S8</p>
<div>Abstract<p>Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration cytotoxic immune cells. The mechanisms driving these remain unclear. Herein, we demonstrate that exercise normalizes vasculature upregulates endothelial expression of VCAM1 in YUMMER 1.7 B16F10 murine models melanoma but differentially regulates growth, hypoxia, response. We found suppressed growth increased CD8<sup>+</sup> T-cell not tumors. Single-cell...
<div>Abstract<p>Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration cytotoxic immune cells. The mechanisms driving these remain unclear. Herein, we demonstrate that exercise normalizes vasculature upregulates endothelial expression of VCAM1 in YUMMER 1.7 B16F10 murine models melanoma but differentially regulates growth, hypoxia, response. We found suppressed growth increased CD8<sup>+</sup> T-cell not tumors. Single-cell...
<p>Supplementary Figures S1-S8</p>
<p>Supplementary Figures S1-S8</p>