A5019098559- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Immune cells in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
- Organ and Tissue Transplantation Research
- HIV Research and Treatment
- Renal and Vascular Pathologies
- Inflammatory Biomarkers in Disease Prognosis
- Thyroid Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- HIV-related health complications and treatments
- Immune Response and Inflammation
- Cancer Genomics and Diagnostics
- Nutrition and Health in Aging
- Head and Neck Cancer Studies
- Hepatitis C virus research
- Pancreatic function and diabetes
- T-cell and B-cell Immunology
- Clinical Nutrition and Gastroenterology
- Diabetes and associated disorders
Dynamic Concepts (United States)
2023-2025
Gift of Life Michigan
2024
Emory University
2017-2022
Link Foundation
2018-2020
American College of Surgeons
2018
Piedmont Atlanta Hospital
2008-2015
Advanced Systems Technology (United States)
2009
University of Alabama at Birmingham
1998-2006
University of Pennsylvania
1997-2005
Chukyo Hospital
2005
Intestinal macrophages, which are thought to orchestrate mucosal inflammatory responses, have received little investigative attention compared with macrophages from other tissues. Here we show that human intestinal do not express innate response receptors, including the receptors for LPS (CD14), Fcalpha (CD89), Fcgamma (CD64, CD32, CD16), CR3 (CD11b/CD18), and CR4 (CD11c/CD18); growth factor IL-2 (CD25) IL-3 (CD123); integrin LFA-1 (CD11a/CD18). Moreover, resident also produce...
Intestinal macrophages, which are thought to orchestrate mucosal inflammatory responses, have received little investigative attention compared with macrophages from other tissues. Here we show that human intestinal do not express innate response receptors, including the receptors for LPS (CD14), Fcα (CD89), Fcγ (CD64, CD32, CD16), CR3 (CD11b/CD18), and CR4 (CD11c/CD18); growth factor IL-2 (CD25) IL-3 (CD123); integrin LFA-1 (CD11a/CD18). Moreover, resident also produce proinflammatory...
Ablative therapies have been increasingly utilized in the treatment of locally advanced pancreatic cancer (LAPC). Irreversible electroporation (IRE) is an energy delivery system, effective ablating tumors by inducing irreversible membrane destruction cells. We aimed to demonstrate efficacy with IRE as part multimodal LAPC.From July 2010 October 2014, patients radiographic stage III LAPC were treated and monitored under a multicenter, prospective institutional review board-approved registry....
Abstract The intestinal mucosa normally displays minimal inflammation despite the close proximity between mucosal macrophages and lumenal bacteria. Macrophages interact with bacteria their products through CD14, a surface receptor involved in response to LPS, CD89, for IgA (FcαR). Here we show that resident isolated from normal human intestine lack CD14 CD89. absence of CD89 was not due isolation procedure or cell products, but evident at transcriptional level, as expressed neither CD14- nor...
Mortality on the liver waitlist remains unacceptably high. Donation after circulatory determination of death (DCD) donors are considered marginal but a potentially underutilized resource. Thoraco-abdominal normothermic perfusion (TA-NRP) in DCD might result higher quality livers and offset mortality. We retrospectively reviewed outcomes first 13 transplanted from TA-NRP US. Nine centers eight organ procurement organizations. Median donor age was 25 years; median agonal phase minutes....
Decisions to transplant organs from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid test-positive (NAT+) donors must balance risk of donor-derived transmission events (DDTE) with the scarcity available organs.Organ Procurement and Transplantation Network (OPTN) data were used compare organ utilization recipient outcomes between SARS-CoV-2 NAT+ NAT- donors. was defined by either a positive upper or lower tract (LRT) sample within 21 days procurement. Potential DDTE...
Although approximately 1 million islets exist in the adult human pancreas, current pancreas preservation and islet isolation techniques recover <50%. Presently, cadaveric donors remain sole source of pancreatic tissue for transplantation. Brain death is characterized by activation proinflammatory cytokines organ injury during reperfusion. In this study, we assessed effects brain on yields functionality. was induced male 250- to 350-g Lewis rats inflation a Fogarty catheter placed...
Abstract The lamina propria of the gastrointestinal mucosa contains largest population mononuclear phagocytes in body, yet little is known about cellular mechanisms that regulate cell recruitment to noninflamed and inflamed intestinal mucosa. Here, we show macrophages do not proliferate. We also a substantial proportion express chemokine receptors for interleukin (IL)-8 transforming growth factor-β (TGF-β), smaller expresses N-formylmethionyl-leucyl-phenylalanine C5a, but, surprisingly, they...
Normothermic regional perfusion (NRP) has emerged as a vital technique in organ procurement, particularly donation after circulatory death (DCD) cases, offering the potential to optimize utilization and improve posttransplant outcomes. Recognizing its significance, American Society of Transplant Surgeons (ASTS) convened work group develop standardized recommendations for abdominal NRP United States.
We sought to compare the efficacy, risks, and costs of whole-organ pancreas transplantation (WOP) with isolated islet (IIT) in treatment patients type I diabetes mellitus.A striking improvement has taken place results IIT regard attaining normoglycemia insulin independence diabetic recipients. Theoretically, this minimally invasive therapy should replace WOP because its risks expense be less. To date, however, no systematic comparisons these 2 options have been reported.We conducted a...
Induction therapy with daclizumab has been shown to be efficacious in the prevention of acute rejection kidney transplant patients. The routine use antibody induction liver transplantation not gained widespread acceptance, except cases renal insufficiency. recent approval prompted us initiate this pilot study using those patients at risk for developing posttransplant insufficiency.This nonrandomized examined 39 last 97 transplants performed University Alabama Birmingham. group received 2...
Sarcopenia and inflammation are independently associated with worse survival in cancer patients. This study aims to determine the impact of sarcopenia, body mass index (BMI), inflammatory biomarkers on advanced hepatocellular carcinoma (HCC) patients treated anti-PD-1 antibody-based immunotherapy.A retrospective review HCC immunotherapy at Winship Cancer Institute between 2015 2019 was performed. Baseline computed tomography magnetic resonance images were collected mid-L3 level, assessed for...
Abstract Background Characterization of transplant transmitted infections associated with drowned organ donors and the recipients is not well delineated, posing challenges for optimal management prophylaxis strategies. Broader sharing may pose additional considerations due to pathogen variation. Methods We reviewed 22 potential donor disease transmission events (PDDTEs) from reported Organ Procurement Transplantation Network (OPTN) ad hoc Disease Transmission Advisory Committee (DTAC)...
Objective To review the experience with operative treatment of tertiary hyperparathyroidism (TH) from a single renal transplant center. Summary Background Data Most patients chronic failure show evidence secondary by time maintenance hemodialysis begins. Persistent (i.e., TH) requiring surgical intervention is uncommon in authors' experience. Methods Charts who underwent parathyroidectomy for TH were reviewed retrospectively. Information obtained included demographics, laboratory data,...
Objective To assess the prognostic significance of molecular biomarkers, particularly c-erbB-2 and p53, through study prospective clinical data archival breast cancer tissues for women accrued to Alabama Breast Cancer Project. Summary Background Data Defining abnormalities in is an important strategy early detection, assessment prognosis, treatment selection. Evidence strong that selective including have cancer. Few studies analyzed coexpression biomarkers. Methods Study patients were those...
Most human immunodeficiency virus type 1 (HIV-1) infections are acquired via mucosal surfaces, and transmitted viruses nearly always macrophage-tropic, suggesting that macrophages participate in early HIV-1 infection. Mucosal lymphocytes isolated from normal intestine expressed CD4 (14,530 ± 7970 antibody-binding sites [ABSs]/cell), CCR5 (2730 1524 ABSs/cell), CXCR4 (2507 1840 but intestinal macrophages, which also (2959 2695 displayed no detectable or ABS. The absence of on was not due to...
Transplantation is increasingly limited by the supply of donor organs. Identifying subgroups that do not support organ donation will allow targeted efforts to increase donation.A total 185 non-acutely ill outpatients visiting a community physician's office voluntarily completed survey designed capture views and general knowledge/misconceptions about cadaveric donation/transplantation.Of patients, 86 were willing donate, 42 unwilling, 57 unsure. Willingness donate was significantly associated...
The influence of ethnic origin on organ donation and renal allograft survival after transplantation has been controversial. Several large studies have reported inferior in black recipients, whereas others equal survival. However, the issue race as it relates to donation, patient referral, selection orthotopic liver not investigated. We retrospectively reviewed our results referral selection, since 1989. Because a concerted educational effort by this procurement organization, percentage...
Background: Early immunologic and non‐immunologic injury of renal allografts adversely affects long‐term graft survival. Some degree preservation is inevitable in cadaveric transplantation, and, with the reduction early acute rejection, this has assumed a greater relative importance. Optimal will maximize chances function survival, but best method – pulsatile perfusion (PP) versus cold storage (CS) debated. Methods: Primary kidney recipients from January 1990 through December 1995 were...
Importance Despite the unmet need for donor organs, organ use from donation after circulatory determination of death (DCD) donors has been limited by inferior transplant outcomes. Normothermic regional perfusion (NRP) improves recipient outcomes and utilization DCD donors. There is variability in NRP policies experience among US procurement organizations (OPOs). Objectives To determine OPO experience, identify operational inconsistencies, explore needs related to NRP. Design, Setting,...