A5012132817- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Pancreatic function and diabetes
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Renal and Vascular Pathologies
- Hepatitis B Virus Studies
- Cannabis and Cannabinoid Research
- Esophageal and GI Pathology
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal Diseases and Glomerulopathies
- Pregnancy and Medication Impact
- Diabetes and associated disorders
- Abdominal vascular conditions and treatments
- Cytomegalovirus and herpesvirus research
- Electrolyte and hormonal disorders
- Dialysis and Renal Disease Management
- Pleural and Pulmonary Diseases
- Metastasis and carcinoma case studies
- Transplantation: Methods and Outcomes
- Congenital Diaphragmatic Hernia Studies
- Dysphagia Assessment and Management
Thomas Jefferson University Hospital
2009-2024
Thomas Jefferson University
2013-2023
LMU Klinikum
2021
Universitätsklinikum des Saarlandes
2017
Jefferson University Hospitals
2016
University of Pennsylvania
2003-2005
Hospital of the University of Pennsylvania
2003-2004
Pennsylvania Hospital
2004
University of Pennsylvania Health System
2003-2004
The Wistar Institute
2003
Type 2 diabetic subjects manifest both disordered insulin action and abnormalities in their pancreatic islet cells. Whether the latter represents a primary defect or is consequence of former unknown. To examine β-cell mass function islets from type patients directly, we isolated pancreata cadaveric donors (n = 14) compared them with normal matched for age, BMI, cold ischemia time. The total recovered was significantly less than that nondiabetic control (256,260 equivalents [2,588 IEq/g...
Background. The Model for End-Stage Liver Disease (MELD) has been found to accurately predict pretransplant mortality and is a valuable system ranking patients in greatest need of liver transplantation. It unknown whether higher MELD score also predicts decreased posttransplant survival. Methods. We examined cohort from the United Network Organ Sharing (UNOS) database whom critical recipient values needed calculate were available (international normalized ratio prothrombin time, total...
Objective To restore islet function in patients whose labile diabetes subjected them to frequent dangerous episodes of hypoglycemic unawareness, and determine whether multiple transplants are always required achieve insulin independence. Summary Background Data The recent report by the Edmonton group documenting restoration independence transplantation seven consecutive with type 1 differed from previous worldwide experience only sporadic success. In patients, transplanted mass critical for...
Recent improvements in isolated islet transplantation indicate that this therapy may ultimately prove applicable to patients with type I diabetes. An obstacle preventing widespread application of is an insufficient supply cadaveric pancreata. Non-heart-beating donors (NHBDs) are generally not deemed suitable for whole-organ pancreas donation and could provide a significant source pancreata transplantation. Isolated pancreatic islets prepared from 10 NHBDs were compared those procured...
We sought to compare the efficacy, risks, and costs of whole-organ pancreas transplantation (WOP) with isolated islet (IIT) in treatment patients type I diabetes mellitus.A striking improvement has taken place results IIT regard attaining normoglycemia insulin independence diabetic recipients. Theoretically, this minimally invasive therapy should replace WOP because its risks expense be less. To date, however, no systematic comparisons these 2 options have been reported.We conducted a...
Survival following liver transplantation for hepatitis C virus (HCV) is significantly poorer than transplants performed other causes of chronic disease. The factors responsible the inferior outcome in HCV+ recipients, and whether they differ from associated with survival HCV- are unknown.The UNOS database was analyzed to identify recipients. Kaplan-Meier graft patient Cox proportional hazards analysis were conducted on 13,026 variables that differentially recipients.Of 7386 (56.7%) 5640...
Segmental liver transplantation with living donor (LD), reduced cadaveric (Reduced), and split (Split) allografts has expanded the availability of size-appropriate organs for pediatric recipients. The relevance recipient age to selection graft type not been fully explored, but could offer potential maximize outcome utilization. We conducted a retrospective cohort study among children 12 years or less utilizing United Network Organ Sharing (UNOS) database. Cox proportional-hazards analysis...
Abstract Introduction Corticosteroids ( CS ) have been standard immunosuppression to prevent and treat rejection. However, are associated with increased risk of infection, obesity, hypertension, hyperlipidemia, diabetes, accelerated hepatitis C virus HCV recurrence post‐orthotopic liver transplantation OLT ). This study assesses the safety efficacy ‐free immunosuppressive regimen in adult . Methods A two‐yr, prospective, randomized delayed withdrawal or basiliximab, tacrolimus,...
Sensitization following renal allograft failure (AF) is highly variable. Some patients remain non-sensitized (NS), while others become sensitized (HS). We studied 66 NS who experienced AF after initial kidney transplantation. Post-failure, two main groups of panel reactive antibody (PRA) class I and II <10% HS (PRA or ≥80%) were identified. The impact acute rejection (AR), immunosuppression withdrawal (ISW) at AF, nephrectomy, graft intolerance syndrome (GIS), both standard serologic...
To examine donor and recipient outcomes after right-sided robotic-assisted laparoscopic nephrectomy (RALDN) compared with standard (LDN) to determine whether robotic-assistance enhances LDN.From December 2005 January 2011, 25 patients underwent LDN or RALDN. An IRB-approved retrospective review was performed of both medical charts. Primary endpoints included intraoperative postoperative outcomes.Twenty LDNs 5 RALDNs were during the study period. Neither estimated blood loss (76.4 mL vs. 30...
We report here the successful treatment of hepatitis C virus (HCV) transmitted from a nucleic acid testing (NAT)-negative donor to three HCV-negative recipients-two renal transplants and one liver. Both recipients underwent standard deceased-donor transplantation with immediate graft function. The liver recipient orthotopic recovered uneventfully. was 39-year-old woman terminal serum creatinine 0.7 mg/dL. She high risk for bloodborne pathogens, based upon history sexual contact an...
Efforts have been made to maximize the utility of each organ transplanted. Policy changes capture unrealized graft years implemented utilizing kidney donor profile index (KDPI). Understanding impact KDPI on long-term function is critical an informed acceptance decision.We reviewed records 309 consecutive deceased adult recipients who underwent transplantation at our center. We obtained allografts directly from United Network for Organ Sharing (UNOS) and patients were divided into four...
Expanded-criteria donor (ECD) kidneys are associated with a higher risk of posttransplant failure, but they remain favorable alternative to dialysis. Now that uniform definition "expanded criteria" exists, it is more appropriate than ever evaluate their utility compared seen non-ECD kidneys.The authors analyzed 202 cadaveric kidney-only recipients underwent transplantation from January 1999 September 2001, including 45 (22%) whose donors met current ECD criteria.ECD and kidney had similar...
The preimplantation kidney biopsy affects utilization by diagnosing glomerulosclerosis, interstitial fibrosis (IF), arteriosclerosis, and arteriolar hyalinosis. Organ procurement organizations (OPOs) determine whether a donor warrants this the hospital pathologists (DHPs) report on an OPO-specific pathology interpretation form. Biopsy slides from 40 deceased kidneys transplanted at our institution were used to compare interpretations between transplant pathologist DHPs. Thirty-three of these...
Acute hypotensive transfusion reactions are newly characterized in which hypotension is the prominent feature. The pathophysiology of acute related to bradykinin function and its metabolism. A liver transplant recipient on treatment with an angiotensin converting enzyme inhibitor developed sudden hypotension, that is, systolic pressure 60 mm Hg, after receiving 200 mL a blood product mixture without significant surgical loss. He responded resuscitation measure, although again challenge...
Immune checkpoint inhibitors (ICPIs) are monoclonal antibodies against inhibitory receptors on T cells resulting in anticancer activity. In kidney transplant (KT) recipients, ICPI use has been associated with acute allograft rejection. failed allografts, however, the effects of ICPIs unknown. We present a case 66-year-old man history diabetes, renal cell cancer, left native nephrectomy, and end-stage disease. He received deceased donor KT which after 6 years due to biopsy-proven recurrent...