A5049179462- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- HIV/AIDS Research and Interventions
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Cardiac Arrest and Resuscitation
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Clinical practice guidelines implementation
- HIV-related health complications and treatments
- Urinary Tract Infections Management
- Bacterial Infections and Vaccines
- Liver Disease and Transplantation
- HIV Research and Treatment
- Hepatitis B Virus Studies
- Antimicrobial Resistance in Staphylococcus
- Traumatic Brain Injury and Neurovascular Disturbances
- Clostridium difficile and Clostridium perfringens research
- Antibiotics Pharmacokinetics and Efficacy
- Vaccine Coverage and Hesitancy
University of California, San Francisco
2020-2025
University of California San Francisco Medical Center
2024
Middlebury College
2024
Chonnam National University
2022-2023
Bio-Medical Science (South Korea)
2022
Drexel University
2010-2022
Korea Institute of Brain Science
2022
Korea Institute of Science and Technology
2022
Korean Association Of Science and Technology Studies
2022
Korea University of Science and Technology
2022
Clinical practice guidelines are developed to assist in patient care. Physicians may assume that following such means practicing evidence-based medicine. However, the quality of supporting literature can vary greatly.We analyzed strength recommendation and overall evidence behind 41 Infectious Diseases Society America (IDSA) released between January 1994 May 2010. Individual recommendations were classified based on their (levels A through C) I III). Guidelines not this format excluded from...
These updated guidelines from the Infectious Diseases Community of Practice American Society Transplantation review diagnosis, prevention, and management HSV in pre- post-transplant period. A majority transplant recipients are seropositive for HSV-1 or 2. Compared with immunocompetent persons, SOT shed more frequently, have severe clinical manifestations, slower to respond therapy. Most infection is diagnosed on grounds, but patients may present atypical lesions and/or other manifestations....
Decisions to transplant organs from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid test-positive (NAT+) donors must balance risk of donor-derived transmission events (DDTE) with the scarcity available organs.Organ Procurement and Transplantation Network (OPTN) data were used compare organ utilization recipient outcomes between SARS-CoV-2 NAT+ NAT- donors. was defined by either a positive upper or lower tract (LRT) sample within 21 days procurement. Potential DDTE...
Although the use of social media to spread misinformation and disinformation is not a new concept, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has further highlighted dangers that can pose public health. More than two-thirds Americans receive their news from at least 1 outlet, most which do undergo same review process as academic journals some professional organizations. Unfortunately, this lead inaccurate health information being conveyed truth. The purpose article...
Inducible cyclooxgenase-2 (COX-2) is commonly overexpressed in breast tumors and a target for cancer therapy. Here, we studied the association of COX-2 with survival how this influenced by tumor estrogen HER2 receptor status Akt pathway activation.Tumor COX-2, α (ER) expression phosphorylation Akt, BAD, caspase-9 were analyzed immunohistochemically 248 cases cancer. Spearman's correlation multivariable logistic regression analyses used to examine relationship between characteristics....
The World Health Organization (WHO) recommends multidrug therapy (MDT) for the treatment of paucibacillary and multibacillary forms leprosy, also known as Hansen's disease (HD). MDT combinations dapsone, rifampin, clofazimine have reduced prevalence but are not without adverse effects impacting regimen adherence. Hence, an urgent need exists to consider alternative regimens with improved safety profile that promotes Herein, we described a case series 10 patients HD (nine leprosy one pure...
Abstract Background Characterization of transplant transmitted infections associated with drowned organ donors and the recipients is not well delineated, posing challenges for optimal management prophylaxis strategies. Broader sharing may pose additional considerations due to pathogen variation. Methods We reviewed 22 potential donor disease transmission events (PDDTEs) from reported Organ Procurement Transplantation Network (OPTN) ad hoc Disease Transmission Advisory Committee (DTAC)...
Donor infection or colonization with a multidrug-resistant organism (MDRO) affects organ utilization and recipient antibiotic management. Approaches to identifying donors at risk of carrying MDROs are unknown. We sought determine the factors for among transplant donors. A multicenter retrospective cohort study was conducted four centers between 2015 2016. All deceased who donated least one were included. Cultures obtained during donor's terminal hospitalization procurement evaluated. The...
Abstract Rapid information dissemination is critical in a world changing rapidly due to global threats. Ubiquitous internet access has created new methods of that are rapid, far-reaching, and universally accessible. However, inaccuracies may accompany rapid dissemination, rigorous evaluation primary data through various forms peer review crucial. In an era which high-quality can save lives, it infectious diseases specialists well versed digital strategy effectively disseminate colleagues the...
Background A steady rise in the use of cardiovascular implantable electronic devices (CIEDs), particularly elderly, has led to an increase device-related infections. Although often studied and reported as a single entity, these complications fact comprise heterogeneous group. Specific subgroups may be associated with distinct mortality risks. Methods Medical records all patients who underwent device extraction for CIED-related infection at tertiary referral center between 1991 2007 were...
The impact of donor colonization or infection with multidrug-resistant organisms (MDROs) on solid organ transplant (SOT) recipient outcomes remains uncertain. We thus evaluated the association between MDROs and risk posttransplant infection, graft failure, mortality.A multicenter retrospective cohort study was performed. All SOT recipients a local deceased were included. divided into three exposure groups: whose donors had (1) an MDRO, (2) non-MDRO bacterial candidal organism, (3) no growth...
The safety and effect of intra-arterial (IA) tirofiban, a glycoprotein IIb/IIIa inhibitor, during the stent retriever mechanical thrombectomy (MT) was investigated.From January 2015 to May 2019, total 327 patients underwent large artery occlusions (LAO). Patients were classified into two groups: MT with IA tirofiban (MTT) group only (MTO, without tirofiban) group. Clinical outcomes, radiological results, various complications, such as post hemorrhage, symptomatic other systemic bleeding,...
Nocardia are gram-positive bacteria existing ubiquitously in the environment; they can cause keratitis. asteroides keratitis occurred interface between stromal bed and flap after traumatic detachment of 4 months an initially uncomplicated laser situ keratomileusis (LASIK) procedure.Nocardia was confirmed by culture. Therapy included topical oral trimethoprim-sulfamethoxazole.Thirteen trauma, patient's spectacle-corrected visual acuity 20/20 with a manifest refraction -2.25 -1.00 x 30...
Human immunodeficiency virus (HIV)-infected patients have excellent outcomes following kidney transplantation (KT) but still might face barriers in the evaluation and listing process. The aim of this study was to characterize patient population, referral patterns, HIV-infected who present for KT evaluation. We performed a single-center retrospective cohort were evaluated KT. primary outcome time determination eligibility Between 2011 2015, 105 Of patients, 73 listed by end period. For those...
HIV-infected (HIV+) donor to HIV+ recipient (HIV D+/R+) transplantation might improve access for people living with HIV. However, it remains unknown whether transplant candidates HIV will accept the currently risks of D+/R+ transplantation.We surveyed from 9 US centers regarding willingness organs.Among 116 participants, median age was 55 years, 68% were men, and 78% African American. Most willing organs (87%), deceased (84%), increased infectious risk (70%). Some (30%) concerned about...
The extent to which donor multidrug-resistant organisms (MDROs) affect organ utilization remains unclear. We performed a retrospective cohort study at 4 transplant centers between 2015 and 2016 evaluate this question. All deceased donors who donated least one were included. Exposed had MDRO on culture. Unexposed no MDRO-positive cultures. Only cultures obtained during the donor's terminal hospitalization evaluated. Multivariable regression was used determine association (1) number of organs...
Abstract Background HIV‐positive kidney transplant (KT) recipients have similar outcomes to HIV‐negative recipients. However, patients with advanced disease might face additional barriers initiating the KT evaluation process. We sought characterize comorbidities, viral control and management, resistance, appointment rates in a cohort of evaluation‐eligible patients. Methods included seen between January 1, 2008, December 31, 2015, at primary care HIV clinic who met eligibility by an...
ABSTRACT Background Coccidioidomycosis is a fungal infection that poses serious risk when transmitted through organ transplantation. We analyzed cases reported to the Organ Procurement and Transplantation Network ad hoc Disease Transmission Advisory Committee from 2013 2022. Methods Donors and/or recipients who had positive Coccidioides immitis/posadasii serology, pathology, culture were included in this study. Cases adjudicated as ‘proven’ or ‘probable’ for donor factors, timing of...
Introduction: According to clinical guidelines, there are no differences in early infection rates when utilizing antimicrobial prophylaxis regimens beyond 24 hours. We shortened the regimen from 72 hours liver transplant recipients due rising of resistance. The objective this study is evaluate difference posttransplant outcomes, following protocol change. Design: reviewed adult patients undergoing orthotopic transplantation between June 2013 and December 2015. Patients were stratified into 2...
Abstract Reference genome assemblies have been created from multiple lineages within the Canidae family; however, despite its phylogenetic relevance as a basal genus clade, there is currently no reference for gray fox (Urocyon cinereoargenteus). Here, we present chromosome-level assembly (U. cinereoargenteus), which represents most contiguous, non-domestic canid available to date, with 90% of contained in just 34 scaffolds and contig N50 scaffold 59.4 72.9 Megabases, respectively. Repeat...