A5047283582- Antibiotic Resistance in Bacteria
- Renal Transplantation Outcomes and Treatments
- Cannabis and Cannabinoid Research
- Antibiotics Pharmacokinetics and Efficacy
- Urinary Tract Infections Management
- Organ Donation and Transplantation
- Drug Transport and Resistance Mechanisms
- Blood donation and transfusion practices
- Opioid Use Disorder Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Transplantation: Methods and Outcomes
- HIV, Drug Use, Sexual Risk
- Cytomegalovirus and herpesvirus research
- Adenosine and Purinergic Signaling
- Family Support in Illness
- Clostridium difficile and Clostridium perfringens research
- Healthcare Policy and Management
- Emergency and Acute Care Studies
- Hospital Admissions and Outcomes
- Childhood Cancer Survivors' Quality of Life
- Counseling Practices and Supervision
University of Pennsylvania
2019-2024
University of Virginia
2012
Donor infection or colonization with a multidrug-resistant organism (MDRO) affects organ utilization and recipient antibiotic management. Approaches to identifying donors at risk of carrying MDROs are unknown. We sought determine the factors for among transplant donors. A multicenter retrospective cohort study was conducted four centers between 2015 2016. All deceased who donated least one were included. Cultures obtained during donor's terminal hospitalization procurement evaluated. The...
The impact of donor colonization or infection with multidrug-resistant organisms (MDROs) on solid organ transplant (SOT) recipient outcomes remains uncertain. We thus evaluated the association between MDROs and risk posttransplant infection, graft failure, mortality.A multicenter retrospective cohort study was performed. All SOT recipients a local deceased were included. divided into three exposure groups: whose donors had (1) an MDRO, (2) non-MDRO bacterial candidal organism, (3) no growth...
The extent to which donor multidrug-resistant organisms (MDROs) affect organ utilization remains unclear. We performed a retrospective cohort study at 4 transplant centers between 2015 and 2016 evaluate this question. All deceased donors who donated least one were included. Exposed had MDRO on culture. Unexposed no MDRO-positive cultures. Only cultures obtained during the donor's terminal hospitalization evaluated. Multivariable regression was used determine association (1) number of organs...
Antibiotic use in deceased organ donors has not been previously described. In a retrospective cohort of 440 donors, we found 427 (97%) received at least one antibiotic course, 312 (71%) broad-spectrum antibiotics, and 61 (14%) potentially redundant antibiotics during their terminal hospitalization, suggesting need for stewardship.
Three members of my family have been diagnosed with cancer in the past five years. During fall freshman year high school, older brother was acute lymphocytic leukemia. His health began to deteriorate August 2006. My mother would take him hospital weekly, insisting that doctors run every test on her ill-ridden son. Chris's diagnosis November 2006 accounted for his rapidly failing and provided treatment options hopefully restore once lively appearance attitude. Now, years after less than a...
Abstract Background Transplant guidelines recommend exercising caution when considering organs that may be infected or colonized with multidrug-resistant organisms (MDROs) and treating the organ recipient perioperative antibiotics active against donor MDRO. Unfortunately, MDROs are often identified only after transplantation. We developed a clinical prediction tool to stratify donors’ MDRO risk at time of evaluation. Methods A retrospective cohort study was conducted four transplant centers...
Due to the ongoing opioid epidemic in United States, deceased organ donors increasingly have a history of injection drug use (IDU), raising concerns about infectious risks solid transplant (SOT) recipients. We sought determine how recent IDU among impacted donor culture results and recipient outcomes.A retrospective cohort study was performed at three centers. Exposed were those with "recent IDU" (in prior 12 months). Primary outcomes included (1) positive cultures for bacteria or Candida...
Abstract Background With the ongoing opioid epidemic in US, there has been an increase proportion of deceased organ donors with a history injection drug use (IDU), raising concern for additional infectious risks to transplantation.We sought determine how recent IDU among impacted donor culture results. Methods A retrospective cohort study was conducted at four transplant centers Philadelphia between 1/1/2015 and 6/30/2016. All who donated ≥ 1 one were included. Exposed those (defined by...