A5029639814- Oral microbiology and periodontitis research
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Salivary Gland Disorders and Functions
- Dental Health and Care Utilization
- S100 Proteins and Annexins
- Influenza Virus Research Studies
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Renal Diseases and Glomerulopathies
- Cervical Cancer and HPV Research
- Dental Radiography and Imaging
- Geotechnical Engineering and Analysis
- Eosinophilic Esophagitis
- Fermentation and Sensory Analysis
- Galectins and Cancer Biology
- Dental Erosion and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis B Virus Studies
- Uterine Myomas and Treatments
- Head and Neck Cancer Studies
- Health and Wellbeing Research
- Oral Health Pathology and Treatment
- Cell Adhesion Molecules Research
Seoul National University
2020-2022
University Of Transport Technology
2021
University of California, Irvine Medical Center
2017
University of Alabama at Birmingham
2000-2016
Oxford University Clinical Research Unit
2014
University of Alabama
2001
Czech Academy of Sciences
1994
Czech Academy of Sciences, Institute of Microbiology
1994
Aberrant glycosylation of IgA1 plays an essential role in the pathogenesis IgA nephropathy. This abnormality is manifested by a deficiency galactose hinge-region O-linked glycans IgA1. Biosynthesis these occurs stepwise fashion beginning with addition N-acetylgalactosamine enzyme N-acetylgalactosaminyltransferase 2 and continuing either β1,3-galactosyltransferase or terminal sialic acid N-acetylgalactosamine–specific α2,6-sialyltransferase. To identify molecular basis for aberrant...
Abstract The lamina propria of the gastrointestinal mucosa contains largest population mononuclear phagocytes in body, yet little is known about cellular mechanisms that regulate cell recruitment to noninflamed and inflamed intestinal mucosa. Here, we show macrophages do not proliferate. We also a substantial proportion express chemokine receptors for interleukin (IL)-8 transforming growth factor-β (TGF-β), smaller expresses N-formylmethionyl-leucyl-phenylalanine C5a, but, surprisingly, they...
Introduction Community acquired K. pneumoniae pneumonia is still common in Asia and reportedly associated with alcohol use. Oropharyngeal carriage of could potentially play a role the pathogenesis pneumonia. However, little known regarding oropharyngeal rates risk factors. This population-based cross-sectional study explores association variety demographic socioeconomic factors, as well consumption Vietnam. Methods Findings 1029 subjects were selected randomly from age, sex, urban rural...
Cement stabilized soil is one of the commonly used as ground reinforcement solutions in geotechnical engineering. In this study, main object was to apply three machine learning (ML) methods namely gradient boosting (GB), artificial neural network (ANN) and support vector (SVM) predict unconfined compressive strength (UCS) cement soil. Soil samples were collected at Hai Duong city, Vietnam. A total 216 soil–cement mixed laboratory compressed determine UCS. This data set divided into two parts...
Heterosubtypic immunity (HSI), defined as protective cross-reactivity to lethal infection with influenza A virus of a serotype different from the initially encountered, is thought be mediated by cross-reactive cytotoxic T lymphocytes (CTL). This study provides direct evidence for role effector CTL versus B cells in HSI mice targeted disruption α chain CD8 molecule (CD8+ cell deficient) or immunoglobulin µ heavy (B deficient), respectively. CD8+ cell-deficient developed complete HSI. These...
ABSTRACT Heterosubtypic immunity (HSI) is defined as cross-protection to infection with an influenza A virus serotype other than the one used for primary infection. Although HSI has been thought be mediated by cross-reactive cytotoxic T lymphocytes (CTL) that recognize conserved epitopes of structural proteins, recent studies suggest antibodies (Abs) may make a significant contribution. In this study, we provide further evidence role Abs in using transgenic mice lacking terminal...
ABSTRACT Heterosubtypic immunity (HSI) is defined as cross-protection against influenza virus of a different serotype than the initially encountered and thought to be mediated by virus-specific cytotoxic T lymphocytes (CTL). Since gamma interferon (IFN-γ) stimulates cells, including antigen-specific CTL which may control replication secretion antiviral cytokines such tumor necrosis factor alpha IFN-γ, we have investigated mechanism HSI analyzing role IFN-γ for in gene-deleted (IFN-γ −/− )...
Periodontitis is one of major oral diseases, which has no consensus on early screening tool. This study aimed to compare the association and ability S100A8 S100A9 in saliva, blood gingival crevicular fluid (GCF) for periodontitis status.We recruited 149 community Korean adults, 50 or initial (NIPERIO) 99 established (PERIO). Using clinical attachment loss a panoramic radiograph, stage II-IV new classification proposed at 2018 was considered cases as PERIO. Enzyme linked immunosorbent assay...
Over 90% of oral cancers are squamous cell carcinoma (OSCC). Hitherto, early detection marker for OSCC has not been available. Hence, this study aimed to evaluate the diagnostic and prognostic ability salivary matrix-metalloproteinase-9 (MMP-9) 8-hydroxydeoxyguanosine (8-OHdG) OSCC. Total 318 participants with 106 cases 212 controls were included: from Seoul National University Dental Hospital age, sex, smoking matched Yangpyeong cohort. Unstimulated saliva was collected determine MMP-9...
Abstract Aim This cross‐sectional study aimed to examine the diagnostic ability of salivary matrix metalloproteinase (MMP)‐9 lateral flow test (LFT) point‐of‐care (POC) kit and develop an algorithm for diagnosis periodontitis. Materials Methods Through Seoul National Dental Hospital, 137 participants (46 LFT negatives, 91 positives) were recruited. For diagnostics, 150 μl unstimulated saliva was applied LFT‐POC kit. To make a periodontitis, stage II‐IV in modified new international...
Abstract Objective To evaluate the association between oral health-related quality of life (OHRQoL) and health indicators including dental status, total occlusion force (TOF), number natural rehabilitated teeth (NRT), (NT), to explore effect modification on by gender among Korean elders. Methods A 675 participants aged 65 or above recruited a cluster-based stratified random sampling were included in this cross-sectional study. The 14-items version Oral Health Impact Profile (OHIP) was used...
Abstract Background Salivary function has been suggested to be associated with cognitive impairment. However, the effect of salivary flow rate (SFR) on impairment remains unclear. This study aimed investigate whether SFR is among Korean elders. Methods cross-sectional included 649 elders aged 65 and older in community-dwelling population. Cognitive was assessed using Mini-Mental Status Examination. Unstimulated measured dichotomized. Denture status, age, sex, education level, smoking,...
Abstract Background This study aimed to investigate the distribution of objective total occlusal force (TOF) and its association with dental health indicators: status, number natural teeth (NT), rehabilitated teeth, posterior (NT-Post), among Korean elders after controlling for various confounders encompassing socio-demographic factors, behavioral factors health/oral factors. Methods cross-sectional recruited 551 from Sungbook-Gu education cohort. TOF was measured using Prescale II as an...
Abstract Objectives This study aimed to develop a new chewing problem directory (CPD) and validate it with oral health indicators such as total occlusion force, number of natural rehabilitated teeth (NRT), NRT posterior, teeth, dental status among Korean elders. Background Chewing is the main in However, there has been no validated tool using both subjective objective assessment problem. Subjects methods A 537 participants aged 65 years or more were randomly assigned into 2 subsamples:...