A5087106402- Immune Response and Inflammation
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Cardiac pacing and defibrillation studies
- Viral Infections and Immunology Research
- Vector-borne infectious diseases
- Immune Cell Function and Interaction
- Helicobacter pylori-related gastroenterology studies
- Immunotherapy and Immune Responses
- Genomics, phytochemicals, and oxidative stress
- Liver Disease Diagnosis and Treatment
- Viral Infections and Vectors
- T-cell and B-cell Immunology
- Veterinary medicine and infectious diseases
- PARP inhibition in cancer therapy
- Galectins and Cancer Biology
- Cardiac Arrhythmias and Treatments
- Glutathione Transferases and Polymorphisms
- Metabolism and Genetic Disorders
- Mosquito-borne diseases and control
- Genetics and Neurodevelopmental Disorders
- DNA Repair Mechanisms
- Animal Virus Infections Studies
- Cardiovascular Function and Risk Factors
University of Dundee
2020-2024
Ninewells Hospital
2020-2021
MRC Protein Phosphorylation and Ubiquitylation Unit
2020-2021
St. Anna Hospital
1992-2004
University of Alabama at Birmingham
1998-2004
Masaryk University
2004
University of Alabama
2003
Cedars-Sinai Medical Center
2000
La Jolla Institute for Immunology
2000
New South Wales Department of Primary Industries
1996
Polymeric microspheres were evaluated as an oral antigen delivery system for immunization with influenza virus. The immune responses obtained compared after either or systemic of BALB/c mice using purified, formalin-inactivated virus type A/H3N2, encapsulated in biodegradable and biocompatible free solution. immunogenicity formalin-treated vaccine was preserved during the microencapsulation process, microencapsulated induced protective that equal to higher than those by conventional vaccine....
The optimization of atrioventricular (AV) delay is known to signifcantly contribute maximum cardiac performance. aim this study was validate a new, fast, and simple echocardiographic method identifying the AV that provides output (CO). Right heart catheterization Doppler echocardiography transmitral filling were performed simultaneously in 18 patients with failure at least minimum functional mitral regurgitation treated atrial synchronized biventricular pacing. CO derived from parameters...
Mutations in the gene encoding CDKL5 kinase are among most common genetic causes of childhood epilepsy and can also give rise to severe neurodevelopmental condition CDD (CDKL5 deficiency disorder). Despite its importance for human health, phosphorylation targets cellular roles poorly understood, especially cell nucleus. Here, we report that is recruited sites DNA damage actively transcribed regions A quantitative phosphoproteomic screen nuclear substrates reveals a network transcriptional...
ABSTRACT Heterosubtypic immunity (HSI) is defined as cross-protection against influenza virus of a different serotype than the initially encountered and thought to be mediated by virus-specific cytotoxic T lymphocytes (CTL). Since gamma interferon (IFN-γ) stimulates cells, including antigen-specific CTL which may control replication secretion antiviral cytokines such tumor necrosis factor alpha IFN-γ, we have investigated mechanism HSI analyzing role IFN-γ for in gene-deleted (IFN-γ −/− )...
Journal Article Microencapsulated Human Parainfluenza Virus Induces a Protective Immune Response Get access Ranjit Ray, Ray Search for other works by this author on: Oxford Academic PubMed Google Scholar Miroslav Novak, Novak Jacqueline D. Duncan, Duncan Yumiko Matsuoka, Matsuoka Reprints or correspondence: Y. Secretech, lnc., 1025 18th St. S., Suite 201, Birmingham, AL 35205. Richard W. Compans The of Infectious Diseases, Volume 167, Issue 3, March 1993, Pages 752–755,...
Enveloped animal viruses must undergo membrane fusion to deliver their genome into the host cell. We demonstrate that high pressure inactivates two membrane-enveloped viruses, influenza and Sindbis, by trapping particles in a fusion-intermediate state. The pressure-induced conformational changes Sindbis were followed using intrinsic extrinsic fluorescence spectroscopy, circular dichroism, fusion, plaque, hemagglutination assays. Influenza virus subjected exposes hydrophobic domains as...
ABSTRACT We have investigated the mechanisms involved in clearance of viral infection at epithelium level by analyzing activity influenza virus-specific cytotoxic T lymphocytes (CTL) against virus-infected CMT-93 intestinal epithelial cells. Epithelial cells infected with live virus effectively present antigens and were lysed both homotypic heterotypic CD8 + These results shed new light on control through elimination CTL demonstrate that furnish an appropriate model for vitro evaluation
Poliovirus-based vectors (replicons) can be used for gene delivery to motor neurons of the CNS. In current study, a replicon encoding green fluorescent protein (GFP) was encapsidated into authentic poliovirions, using established procedures. Intrathecal replicons GFP CNS mice transgenic human poliovirus receptor did not result in any functional deficits as judged by behavioral testing. Histological analysis given single intrathecal injection revealed no obvious pathogenesis (or other cell...
Transcription factor nuclear erythroid 2 p45-related (Nrf2) is the principal determinant of cellular redox homeostasis, contributing to mitochondrial function, integrity and bioenergetics. The main negative regulator Nrf2 Kelch-like ECH associated protein 1 (Keap1), a substrate adaptor for Cul3/Rbx1 ubiquitin ligase, which continuously targets ubiquitination proteasomal degradation. Loss-of-function mutations in Keap1 occur frequently lung cancer, leading constitutive activation. We used...
Vaccines that stimulate both cellular and humoral immunity will probably be needed to control many infectious diseases. Previously, our laboratory generated a vaccine vector uses poliovirus genomes (replicons) in which the capsid genes have been replaced by foreign proteins. In current study, we evaluated immune responses induced immunization using replicons encoding green fluorescent protein (GFP). Although intramuscular administration of resulted GFP expression muscle, levels anti-GFP...