A5004609752- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Congenital heart defects research
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Congenital gastrointestinal and neural anomalies
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Wnt/β-catenin signaling in development and cancer
- Cardiomyopathy and Myosin Studies
- Microscopic Colitis
- Genetic factors in colorectal cancer
- Gut microbiota and health
- Neuroendocrine Tumor Research Advances
- Barrier Structure and Function Studies
- Dermatology and Skin Diseases
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Immune Response and Inflammation
- Lung Cancer Research Studies
- Hidradenitis Suppurativa and Treatments
- Digestive system and related health
Charité - Universitätsmedizin Berlin
2013-2024
Humboldt-Universität zu Berlin
2024
Freie Universität Berlin
2024
Johannes Gutenberg University Mainz
2018
University of Rostock
2018
University Medical Center of the Johannes Gutenberg University Mainz
2018
Max Delbrück Center
2013-2014
Congenital heart defects (CHDs) are the most common birth defect worldwide and a leading cause of neonatal mortality. Nonsyndromic atrioventricular septal (AVSDs) an important subtype CHDs for which genetic architecture is poorly understood. We performed exome sequencing in 13 parent-offspring trios 112 unrelated individuals with nonsyndromic AVSDs identified five rare missense variants (two arose de novo) highly conserved gene NR2F2, very significant enrichment (p = 7.7 × 10−7) compared to...
Abstract The colonic epithelial turnover is driven by crypt-base stem cells that express the R-spondin receptor Lgr5. Signals regulate regeneration upon cell injury are largely unknown. Here, we explore dynamics of Wnt signaling in colon. We identify two populations with active signaling: highly proliferative Lgr5 + /Axin2 cells, as well secretory − cells. Upon depletion, these recruited to contribute crypt regeneration. Chemical induced DSS leads a loss both and Axin2 including...
Colibactin, a bacterial genotoxin produced by E. coli strains harboring the pks genomic island, induces cytopathic effects, such as DNA breaks, cell cycle arrest, and apoptosis. Patients with inflammatory bowel diseases, ulcerative colitis, display changes in their microbiota expansion of coli. Whether how colibactin affects integrity colonic mucosa whether pks+ contributes to pathogenesis colitis is not clear. Using gnotobiotic mouse model, we show that under homeostatic conditions, do...
Cells that lack p53 signaling frequently occur in ulcerative colitis (UC) and are considered early drivers UC-associated colorectal cancer (CRC). Epithelial injury during is associated with transient stem cell reprogramming from the adult, homeostatic to a "fetal-like" regenerative state. Here, we use murine organoid-based models study role of
AIMTo establish cell line and patient-derived xenograft (PDX) models for neuroendocrine carcinomas (NEC) which is highly desirable gaining insight into tumor development as well preclinical research including
Abstract Colitis-associated colorectal cancer (CAC) seems to be a rather unique entity and differs in its genetic alterations, tumour formation capacities clinical features from sporadic carcinoma. Most descriptions about biology of CAC refer ulcerative colitis; data Crohn´s colitis related carcinomas are scarce. The majority patients with disease under immunosuppression which generates different environment for growth. We first describe the case fast growing long-term immunosuppressed...
Das Kolonepithel zeichnet sich durch einen hohen Zellumsatz aus, was Wnt-abhängige Lgr5-positive Stammzellen in den Kryptenbasen reguliert wird. Es ist unbekannt wie die Integrität des Epithels nach einer Schädigung der Krypten im Rahmen Kolitis wiederhergestellt