A5063127661- Retinoids in leukemia and cellular processes
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Neurogenesis and neuroplasticity mechanisms
- Antioxidant Activity and Oxidative Stress
- Cancer Research and Treatments
- Diet and metabolism studies
- RNA regulation and disease
- Muscle metabolism and nutrition
- Vitamin C and Antioxidants Research
- Mitochondrial Function and Pathology
- Veterinary Oncology Research
- Retinal Diseases and Treatments
- FOXO transcription factor regulation
- Mesenchymal stem cell research
- Glioma Diagnosis and Treatment
- Kruppel-like factors research
- Retinal Development and Disorders
- Cancer-related Molecular Pathways
- Fibroblast Growth Factor Research
- Immune cells in cancer
- Thyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
Humboldt-Universität zu Berlin
2020-2024
Charité - Universitätsmedizin Berlin
2020-2024
Freie Universität Berlin
2020-2024
Instituto del Mar del Peru
2024
Tongji University
2024
Henan Polytechnic University
2024
Boston College
2013-2018
Chestnut Hill College
2014
University of California, Santa Barbara
2014
Columbia University
1999
alpha-Internexin is the first neuronal intermediate filament (IF) protein expressed in postmitotic neurons of developing nervous system. In adult, its expression restricted to mature CNS. To study potential role alpha-internexin neurodegeneration, we have generated transgenic mice that overexpress rat alpha-internexin. The total levels hemizygous and homozygous were approximately 2 3 times normal level, respectively. Overexpression resulted formation cerebellar torpedoes as early 1 month...
Retinol saturase (RetSat) is an oxidoreductase involved in lipid metabolism and the cellular sensitivity to peroxides. RetSat highly expressed metabolic organs like liver adipose tissue its global loss mice increases body weight adiposity. The regulation of expression function intestine are unexplored. Here, we show that present different segments digestive system, localizes intestinal epithelial cells, upregulated by feeding high-fat diet (HFD). Intestine-specific deletion adult did not...
Cells that lack p53 signaling frequently occur in ulcerative colitis (UC) and are considered early drivers UC-associated colorectal cancer (CRC). Epithelial injury during is associated with transient stem cell reprogramming from the adult, homeostatic to a "fetal-like" regenerative state. Here, we use murine organoid-based models study role of
Retinol saturase (RetSat) is an endoplasmic reticulum-localized oxidoreductase highly expressed in organs involved lipid metabolism such as white (WAT) and brown adipose tissue (BAT). Cold exposure was shown to increase RETSAT protein BAT but its relevance for non-shivering thermogenesis, a process with beneficial effects on metabolic health, unknown. We analyzed the regulation of RetSat expression adipocytes different murine depots upon β-adrenergic stimulation cold exposure. function...
Despite a similar fat storing function, visceral (intra-abdominal) white adipose tissue (WAT) is detrimental, whereas subcutaneous WAT considered to protect against metabolic disease. Recent findings indicate that thermogenic genes, expressed in brown (BAT), can be induced primarily WAT. Here, we investigate the hypothesis Wilms tumour gene product (WT1), which intra-abdominal but not and BAT, suppresses program cells.Heterozygous Wt1 knockout mice their wild-type littermates were examined...
Hepatocytes secrete retinol-binding protein 4 (RBP4) into circulation, thereby mobilizing vitamin A from the liver to provide retinol for extrahepatic tissues. Obesity and insulin resistance are associated with elevated RBP4 levels in blood. However, a previous study, we observed that chronically increased by forced Rbp4 expression does not impair glucose homeostasis mice. Here, investigated effects of an acute mobilization hepatic stores overexpression We show decreases body fat content...
Thyroid hormones (TH) are major regulators of cell differentiation, growth, and metabolic rate. TH synthesis in the thyroid gland requires high amounts H
Abstract Mycoplasma are the smallest self-replicating prokaryotes and burdened by their notoriety. It is widely unknown that mycoplasma readily detected in many primary human cancer tissues can influence tumorigenesis. Some species such as M. fermentans hyorhinis transform normal murine cell lines into tumorigenic cells. infection inactivate tumor suppressor genes activate oncogenes. These observations suggest be both carcinogenic or onco-modulators. We found arginini was present metastatic...
Mycoplasmas are the smallest, self‐replicating free‐living prokaryotes, and have been associated with carcinogenesis. can be detected in a large percentage wide variety of primary human cancers. Some mycoplasma species such as M. fermentans hyorhinis transform normal murine cell lines into tumorigenic cells. Mycoplasma infection activate oncogenes well inactivate tumor suppressor genes suggesting that mycoplasmas both carcinogenic or onco‐modulatory. PCR amplification sequencing showed...
Abstract It is well documented that energy metabolism differs between cancerous tissue and normal for a large variety of human animal tumors. The murine J2 retrovirus contributes to oncogenesis in macrophage cells. BV-2 microglia cells were immortalized using the v-raf/v-myc carrying retrovirus. These cells, however, do not form tumors when grown vivo natural C57BL/6 host. Consistent with expression, vitro metabolic proliferation rate greatly exceeded tumorigenic metastatic VM-M3 DMEM...