A5023827041- RNA modifications and cancer
- Viral Infections and Vectors
- Genetics and Neurodevelopmental Disorders
- Neurobiology and Insect Physiology Research
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- Metastasis and carcinoma case studies
- Bacteriophages and microbial interactions
- BRCA gene mutations in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mosquito-borne diseases and control
- CRISPR and Genetic Engineering
- Signaling Pathways in Disease
- RNA Interference and Gene Delivery
- Antibiotic Resistance in Bacteria
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Cellular Mechanics and Interactions
- Genomics and Chromatin Dynamics
- Virus-based gene therapy research
- Influenza Virus Research Studies
- Erythrocyte Function and Pathophysiology
- Genetic Associations and Epidemiology
- Respiratory viral infections research
- Molecular Biology Techniques and Applications
University of Cambridge
2016-2025
Changhai Hospital
2016-2025
Second Military Medical University
2016-2025
Children's Hospital of Philadelphia
2020-2024
Hebei Medical University
2006-2024
Xingtai People's Hospital
2024
Shanghai Jiao Tong University
2020-2024
Zhejiang University
2020-2024
Sir Run Run Shaw Hospital
2024
Zhongkai University of Agriculture and Engineering
2024
Genetic testing for breast cancer susceptibility is widely used, but many genes, evidence of an association with weak, underlying risk estimates are imprecise, and reliable subtype-specific lacking.
This review concerning transition-metal-oxides-based electrocatalysts for the oxygen reduction reaction in metal–air batteries will encourage enthusiasm of researchers to develop efficient catalysts power sources used electric vehicles.
We aimed to clarify the epidemiologic and clinical importance of evolutionary events that occurred in carbapenem-resistant Klebsiella pneumoniae (CRKP). collected 203 CRKP causing bloodstream infections a tertiary hospital China during 2013-2017. detected subclonal shift dominant clone sequence type (ST) 11 which previously prevalent capsular loci (KL) 47 had been replaced by KL64 since 2016. Patients infected with ST11-KL64 significantly higher 30-day mortality rate than other CRKP-infected...
Abstract Several genome- and proteome-wide studies have associated transcription translation changes of CRMP2 (collapsing response mediator protein 2) with psychiatric disorders, yet little is known about its function in the developing or adult mammalian brain vivo . Here we show that brain-specific Crmp2 knockout (cKO) mice display molecular, cellular, structural behavioural deficits, many which are reminiscent neural features symptoms schizophrenia. cKO exhibit enlarged ventricles impaired...
To mimic and use the functions of ion transport system that are central to biological processes, bioinspired ion-selective membranes developed show great potential in a variety fields. However, practical applications them now limited due low pore density, conductivity, or scale-up difficulty. Herein, we demonstrate 2-hydroxyethyl methacrylate phosphate (HEMAP) hydrogel membrane with 3D interconnected nanopores space charged through simple photopolymerization. The HEMAP exhibits high...
Abstract Poly‐γ‐glutamic acid (γ‐PGA) is an important multifunctional biopolymer with various applications, for which adenosine triphosphate (ATP) supply plays a vital role in biosynthesis. In this study, the enhancement of γ‐PGA production was attempted through approaches improving ATP engineered strains Bacillus licheniformis . The first approach to engineer respiration chain branches B. , elimination cytochrome bd oxidase branch reduced maintenance coefficient, leading 19.27% increase...
The causal link between Zika virus (ZIKV) infection and microcephaly has raised alarm worldwide. Microglial hyperplasia, reactive gliosis, myelination delay have been reported in ZIKV-infected microcephalic fetuses. However, whether how ZIKV affects glial cell development remain unclear. Here we show that of embryos at the later stage causes severe after birth. infects progenitors during brain development. Specifically, disturbs proliferation differentiation oligodendrocyte progenitor cells...
Abstract Digital PCR has developed rapidly since it was first reported in the 1990s. It recently that an improved method facilitated detection of genetically modified organisms (GMOs). However, to use this method, samples must be pretreated, which could introduce inaccuracy into results. In our study, we explored a pretreatment-free digital for screening GMOs. We chose CaMV35s promoter and NOS terminator as templates assay. To determine specificity 9 events GMOs were collected, including...
Zika virus (ZIKV) has evolved from an overlooked mosquito-borne flavivirus into a global health threat due to its astonishing causal link microcephaly and other disorders. ZIKV been shown infect neuronal progenitor cells of the fetal mouse brain, which is comparable first-trimester human result in microcephaly. However, whether there are different effects between contemporary strain ancestral neonatal with second-trimester unclear. Here we adopted model enables us study postnatal effect...
Pre-mRNA splicing is a highly coordinated process. While its dysregulation has been linked to neurological deficits, our understanding of the underlying molecular and cellular mechanisms remains limited. We implicated pathogenic variants in U2AF2 PRPF19, encoding spliceosome subunits neurodevelopmental disorders (NDDs), by identifying 46 unrelated individuals with 23 de novo missense (including seven recurrent 30 individuals) six PRPF19 variants. Eight dysregulated model substrate....
The role of germline genetics in adjuvant aromatase inhibitor (AI) treatment efficacy ER-positive breast cancer is poorly understood. We employed a two-stage candidate gene approach to examine associations between survival endpoints and common variants 753 endocrine resistance-related genes. For discovery cohort, we screened the Breast Cancer Association Consortium database (n ≥ 90,000 cases) retrieved 2789 AI-treated patients. Cox model-based analysis revealed 125 associated with overall,...
Despite the increasing use of high-flow nasal cannula (HFNC) oxygen therapy during endoscopy examination, its impact on high-risk patients remains uncertain. we aimed to compare HFNC and conventional (COT) bronchoscopy in at for desaturation (morbid obesity, narrow trachea, or baseline hypoxemia and/or hypercapnia). In this multicenter randomized controlled trial (RCT), scheduled presenting with any factors were randomly assigned receive COT after providing written consent. Vital signs,...
A catalyst of silver nanoparticle decorated CeO<sub>2</sub> microspheres was first reported for ORR and applied in an aluminum–air battery with excellent performance.
Neuroregeneration is a dynamic process synergizing the functional outcomes of multiple signaling circuits. Channelrhodopsin-based optogenetics shows feasibility stimulating neural repair but does not pin down specific cascades. Here, we utilized optogenetic systems, optoRaf and optoAKT, to delineate contribution ERK AKT pathways neuroregeneration in live Drosophila larvae. We showed that or optoAKT activation only enhanced axon regeneration both regeneration-competent -incompetent sensory...
Abstract Atr is a serine/threonine kinase, known to sense single-stranded DNA breaks and activate the damage checkpoint by phosphorylating Chek1, which inhibits Cdc25, causing cell cycle arrest. This pathway has not been implicated in neuroregeneration. We show that Drosophila sensory neurons removing or overexpressing Cdc25 promotes regeneration, whereas Chek1 overexpression, knockdown impedes regeneration. Inhibiting Atr-associated complex regeneration improves synapse/behavioral recovery...
Exome sequencing and Drosophila modeling revealed variants in SMARCA5 as a novel cause of neurodevelopmental disorder.
Abstract Primary membranous nephropathy (PMN) is one of the leading causes end‐stage renal disease, and most frequent cause massive proteinuria in nondiabetic adults, resulting fatal complications. However, underlying pathomechanisms PMN remain largely unclear. Here, single‐cell RNA sequencing employed to analyze kidney biopsies from eleven patients seven healthy subjects. Profiling 44 060 cells allowed us characterize cellular composition cell‐type‐specific gene expression kidney. The...