A5085903263- Digital Radiography and Breast Imaging
- AI in cancer detection
- Breast Cancer Treatment Studies
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- BRCA gene mutations in cancer
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Artificial Intelligence in Healthcare and Education
- Endometrial and Cervical Cancer Treatments
- Advanced X-ray Imaging Techniques
- Advanced X-ray and CT Imaging
- Global Cancer Incidence and Screening
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Advanced MRI Techniques and Applications
- Phosphodiesterase function and regulation
- Infrared Thermography in Medicine
- Cervical Cancer and HPV Research
- Cancer survivorship and care
- Advanced Breast Cancer Therapies
- Heart Failure Treatment and Management
- Bone Metabolism and Diseases
- Digital Imaging in Medicine
Universitätsklinikum Erlangen
2016-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Comprehensive Cancer Center Erlangen
2016-2025
Institute of Medical Ethics
2024
Johannes Kepler University of Linz
2021
Bayer (Germany)
2020
University of Göttingen
2012-2014
German Centre for Cardiovascular Research
2013-2014
Universitätsmedizin Göttingen
2013-2014
Juzo (Germany)
2012
To investigate the capacity of chat-generative pre-trained transformer (Chat-GPT) to understand S2k guideline German Society for Gynecology and Obstetrics on intrauterine growth restriction.
To examine the potential of artificial intelligence (AI) in gynecologic oncology decision making. Feasibility study. Fictive. Fictitious case vignettes carcinomas. carcinomas were created and evaluated by physicians with varying levels professional experience, as well language models including Chat-GPT 4.0, Google Gemini, Bing-Copilot. Treatment approval decisions based on standardized clinical laboratory criteria. Two cases breast cancer, one ovarian cervical cancer endometrial evaluated....
Recent studies suggest that the signal molecules cAMP and cGMP have antifibrotic effects by negatively regulating pathways associated with fibroblast to myofibroblast (MyoCF) conversion. The phosphodiesterase 2 (PDE2) has unique property be stimulated cGMP, which leads a remarkable increase in hydrolysis thus mediates negative cross-talk between both pathways. PDE2 been recently investigated cardiomyocytes; here we specifically addressed its role conversion cardiac fibrosis. is abundantly...
Background/Aim: Demographic change and increasing complexity of therapy decisions lead to a growing burden on the healthcare system, necessitating efforts simplify enhance efficiency patient care. The present study evaluates ChatGPT's ability provide recommendations for gynecological malignancies that are both in line with local guidelines individually tailored patient. Patients Methods: Sixteen patients endometrial, cervical, ovarian cancer who were treated clinic University Hospital...
Highlights•Chat-GPT's potential as a clinical support tool in emergency medicine.•Value of utilizing AI addition to human knowledge.•Variations urgency rating and management nuance between subjects.AbstractObjectiveTo investigate the artificial intelligence (AI) medicine, focusing on its utility triaging managing acute gynecologic obstetric emergencies.Methods MaterialsThis feasibility study assessed Chat-GPT's performance recommending interventions for emergencies, using ten fictive cases....
Abstract Background Peripheral blood mononuclear cells (PBMCs) are valuable biomarkers, providing crucial insights into the patients’ immune system. Reliable biobanking of PBMCs is essential to minimize heterogeneity. In multicenter trials, sample transportation central laboratories can increase time between collection and PBMC isolation. This study evaluated effect prolonged hold on viability cytotoxicity. Methods From July 2021 May 2023, 104 patients with early HER2-positive breast cancer...
Abstract The objective of this IRB approved retrospective study was to apply deep learning identify magnetic resonance imaging (MRI) artifacts on maximum intensity projections (MIP) the breast, which were derived from diffusion weighted (DWI) protocols. dataset consisted 1309 clinically indicated breast MRI examinations 1158 individuals (median age [IQR]: 50 years [16.75 years]) acquired between March 2017 and June 2020, in a DWI sequence with high b-value equal 1500 s/mm 2 acquired. From...
Analysis of circulating cell-free DNA (ccfDNA) is a suitable tool for detecting somatic mutations the purpose making decisions on treatment, monitoring treatment response, and predicting survival. High-throughput techniques ccfDNA extraction are essential to implementing testing in clinical setting. We set out compare two automated with regard hands-on time, output integrity, mitochondrial (mtDNA). CcfDNA was isolated using EZ1&2 field test kit (EZ2 kit, QIAGEN) Maxwell RSC plasma (Maxwell...
ABSTRACT Background Virtual contrast-enhanced (vCE) imaging techniques are an emerging topic of research in breast MRI. Purpose To investigate how different combinations T1-weighted (T1w), T2-weighted (T2w), and diffusion-weighted (DWI) impact the performance vCE Materials Methods The IRB-approved, retrospective study included 1064 multiparametric MRI scans (age:52±12 years) obtained from 2017-2020 (single site, two 3T MRI). Eleven independent neural networks were trained to derive images...
Before the era of immunotherapies and antibody-drug conjugates, there were limited chemotherapeutic options for patients with recurrent metastatic cervical cancer. Combination therapies cisplatin have shown some superiority over monotherapy. This study examined platinum-free treatment regimens, comparing a combination topotecan paclitaxel (TP) (TC) in or cancer, without prior platinum-based treatment.
Abstract Background Breast magnetic resonance imaging (MRI) protocols often include T2-weighted fat-saturated (T2w-FS) sequences, which are vital for tissue characterization but significantly increase scan time. Purpose This study aims to evaluate whether a 2D-U-Net neural network can generate virtual T2w-FS images from routine multiparametric breast MRI sequences. Materials and Methods IRB approved, retrospective included n=914 examinations performed between January 2017 June 2020. The...
Mammographic density (MD) is one of the strongest risk factors for breast cancer (BC). However, influence MD on BC prognosis unclear. The objective this study was therefore to investigate whether percentage (PMD) associated with a difference in disease-free or overall survival primary patients.A total 2525 patients primary, metastasis-free were followed up retrospectively analysis. For all patients, PMD evaluated by two readers using semi-automated method. association between and Cox...
We used a shifted-excitation Raman difference spectroscopy method for the ex vivo classification of resected and formalin-fixed breast tissue samples as normal (healthy) tissue, fibroadenoma, or invasive carcinoma. analyzed 8 containing carcinoma that were surrounded by 3 with fibroadenoma only. made various measurement sites on samples, in total 240 measurements each type tissue. Although acquired raw spectra contain enough information to clearly differentiate between tumor (fibroadenoma...
Objective Three‐dimensional (3D) printing has become widely available, and a few cases of its use in clinical practice have been described. The aim this study was to explore facilities for the semi‐automated delineation breast cancer tumors assess feasibility 3D tumors. Methods In case series five patients, different imaging methods—magnetic resonance (MRI), digital tomosynthesis (DBT), ultrasound—were used capture data volumes were calculated comparability tumor models, MRI information...
Background X‐ray dark‐field radiography could enhance mammography by providing more information on imaged tissue and microcalcifications. The dark field signal is a measure of small angle scattering can thus provide additional the materials. This be useful for material distinction calcifications diagnosis breast cancer classifying benign malign association these calcifications. Methods: For this study, institutional review board approval was obtained. We present evaluation images acquired...