A5083265378- Diabetes and associated disorders
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Diabetes Management and Research
- Microplastics and Plastic Pollution
- Phagocytosis and Immune Regulation
- Nanoparticles: synthesis and applications
- Neonatal Respiratory Health Research
- Graphene and Nanomaterials Applications
- Psoriasis: Treatment and Pathogenesis
- Orthopaedic implants and arthroplasty
- MicroRNA in disease regulation
- Recycling and Waste Management Techniques
- Immunotherapy and Immune Responses
- Child and Adolescent Health
- Immune Response and Inflammation
- Hematopoietic Stem Cell Transplantation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2019-2024
Universitat Autònoma de Barcelona
2019-2024
Radboud University Nijmegen
2021
Radboud University Medical Center
2021
Plastic pollution is a global problem. Animals and humans can ingest inhale plastic particles, with uncertain health consequences. Nanoplastics (NPs) are particles ranging from 1 nm to 1000 that result the erosion or breakage of larger debris, be highly polydisperse in physical properties heterogeneous composition. Potential effects NPs exposure may associated alterations xenobiotic metabolism, nutrients absorption, energy cytotoxicity, behavior. In humans, no data on absorptions has been...
BackgroundNeutrophil accumulation in the skin is a hallmark of psoriasis. Novel insights on neutrophil phenotypic and functional heterogeneity raise question to what extent these cells contribute sustained inflammatory reaction.ObjectiveWe sought examine phenotype properties neutrophils blood patients with psoriasis, effect TNF-α p40(IL-12/IL-23) antibody therapy circulating neutrophils.MethodsThirty-two psoriasis were enrolled an observational study performed 2 university hospitals. We...
Type 1 diabetes (T1D) results from a breakdown in immunological tolerance, with pivotal involvement of antigen-presenting cells. In this context, antigen-specific immunotherapies have been developed to arrest autoimmunity, such as phosphatidylserine (PS)-liposomes. However, the role certain cells immunotherapy, particularly human macrophages (Mφ) T1D remains elusive. The aim study was determine Mφ immune tolerance and T1D. To that end, we evaluated ability capture apoptotic-body mimicking...
Type 1 diabetes (T1D) is a chronic metabolic disease characterized by the autoimmune destruction of β-cells in pancreatic islets. T1D preceded islet-specific inflammation led several immune cells. Among them, natural killer (NK) cells are emerging as important players development. Human NK CD56 and CD16 expression, which allows classifying into four subsets: 1) dim + or effector (NK eff ); 2) bright − regulatory reg 3) intermediate cells; 4) cells, whose function not well determined. Since...
Type 1 diabetes is an autoimmune disease caused by the destruction of insulin-producing β-cells. An ideal immunotherapy should combine blockade response with recovery functional target cell mass. With aim to develop new therapies for type that could contribute β-cell mass restoration, a drug repositioning analysis based on systems biology was performed identify regenerative potential commercially available compounds. Drug strategy used identifying uses approved drugs are outside scope...
The partial remission (PR) phase, a period experienced by most patients with type 1 diabetes (T1D) soon after diagnosis, is characterized low insulin requirements and improved glycemic control. Given the great potential of this phase as therapeutic window for immunotherapies because its association immunoregulatory mechanisms β-cell protection, our objective was to find peripheral immunological biomarkers better characterization, monitoring, prediction. longitudinal follow-up 17 pediatric...
Type 1 diabetes (T1D) is prompted by defective immunological tolerance, an event in which dendritic cells (DCs) are crucial as immune response orchestrators. In fact, they contribute to maintaining tolerance self-antigens, but can also prompt immunogenic against them, leading autoimmunity. Countless factors potentially impact on the proper functionality of DCs, range from altered subset distribution, impaired phagocytic function abnormal gene expression. Moreover, T1D, metabolic...
The partial remission (PR) phase of type 1 diabetes (T1D) is an underexplored period characterized by endogenous insulin production and downmodulated autoimmunity. To comprehend the mechanisms behind this transitory develop precision medicine strategies, biomarker discovery patient stratification are unmet needs. MicroRNAs (miRNAs) small RNA molecules that negatively regulate gene expression modulate several biological processes, functioning as biomarkers for many diseases. Here, we identify...
Abstract Type 1 diabetes is an autoimmune disease caused by the destruction of insulin-producing β-cells. To revert type diabetes, suppression attack should be combined with a β-cell replacement strategy. It has been previously demonstrated that liraglutide, glucagon-like peptide-1 receptor agonist, restores mass in via α-cell transdifferentiation and neogenesis. We report here treatment liraglutide does not prevent spontaneous non-obese diabetic (NOD) mouse model, but it tends to reduce...
Nanoplastics (NPs) and microplastics (MPs) are an emerging threat to global health. They negatively impact ecosystems many physiological processes, causing alterations in xenobiotic metabolism, nutrient uptake, energy or cytotoxicity. In humans, we beginning analyze these plastics for the mechanisms by which they enter organism, accumulate diffuse, their pathogenic potential. NP accumulation has been demonstrated human tissues, such as blood placenta, while others it remains largely...
Nanoplastics (NPs) and microplastics (MPs) are an emerging threat to global health. They negatively impact ecosystems many physiological processes, causing alterations in xenobiotic metabolism, nutrient uptake, energy or cytotoxicity. In humans, we beginning analyze these plastics for the mechanisms by which they enter organism, accumulate, diffuse as well their pathogenic potential. NP accumulation has been demonstrated human tissues, such blood placenta, while others it remains largely...
Betamethasone, a glucocorticoid used to induce lung maturation when there is risk of preterm delivery, can affect the immune system and type 1 diabetes (T1D) incidence in progeny. It has been described that prenatal betamethasone protects offspring from experimental T1D development. The main aim this study was evaluate possible association between exposure humans. Research Design Methods. A retrospective case-control with total 945 children, including 471 patients 474 healthy siblings,...
Hematopoietic stem cell (HSC) transplantation is crucial to cure hematologic malignancies. Umbilical cord blood (UCB) a source of cells, but 90% UCB units are discarded due low cellularity. Improving the engraftment capacities CD34+ cells would allow use that were so far rejected. Betamethasone induces long-term transcriptomic and epigenomic changes in immune through glucocorticoid receptor. We hypothesize could be used owing improvements induced by betamethasone. Isolated HSC from exposed...