A5076107716- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Management and Research
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Neuroethics, Human Enhancement, Biomedical Innovations
- Phagocytosis and Immune Regulation
- Reproductive Health and Technologies
- Birth, Development, and Health
- Reproductive Biology and Fertility
- Biomedical Ethics and Regulation
- Prenatal Screening and Diagnostics
- Diet, Metabolism, and Disease
- Immunotherapy and Immune Responses
- Adenosine and Purinergic Signaling
- Grief, Bereavement, and Mental Health
- Race, Genetics, and Society
- Genetic Mapping and Diversity in Plants and Animals
- Palliative Care and End-of-Life Issues
- Genetic diversity and population structure
- Genetic and phenotypic traits in livestock
- Organ Donation and Transplantation
- Calcium signaling and nucleotide metabolism
Universidad de Granada
2023-2025
Centre National de la Recherche Scientifique
2022-2025
Institut Cochin
2022-2025
Inserm
2022-2025
Université Paris Cité
2022-2025
Universitat Autònoma de Barcelona
2014-2024
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2018-2024
Type 1 diabetes (T1D) is a metabolic disease caused by the autoimmune destruction of insulin-producing β-cells. With its incidence increasing worldwide, to find safe approach permanently cease autoimmunity and allow β-cell recovery has become vital. Relying on inherent ability apoptotic cells induce immunological tolerance, we demonstrated that liposomes mimicking β-cells arrested prevented experimental T1D through tolerogenic dendritic cell (DC) generation. These contained...
<p dir="ltr">Murine pancreatic endocrinogenesis has been extensively studied, but human data remain scarce due to limited sample availability. Here, we first built a large collection of embryonic and fetal pancreases covering the trimester pregnancy explore endocrinogenesis. Using an experimental pipeline combining in toto staining, tissue clearing, light-sheet fluorescence microscopy, show that insulin<sup>+</sup>, glucagon<sup>+</sup>,...
Recombination rates vary in intensity and location at the species, individual, sex chromosome levels. Despite fundamental biological importance of this process, selective forces that operate to shape recombination rate patterns are unclear. Domestication offers a unique opportunity study interplay between selection. In domesticates, intense selection for particular traits is imposed on small populations over many generations, resulting organisms differ, sometimes dramatically, morphology...
Abstract Aims/hypothesis Rodent pancreas development has been described in great detail. On the other hand, there are still gaps our understanding of developmental trajectories pancreatic cells during human ontogenesis. Here, aim was to map spatial and chronological dynamics cell differentiation proliferation by using 3D imaging cleared embryonic fetal pancreases. Methods We combined tissue clearing with light-sheet fluorescence pancreases first trimester pregnancy. In addition, we validated...
Type 1 diabetes (T1D) is a chronic metabolic disease characterized by the autoimmune destruction of β-cells in pancreatic islets. T1D preceded islet-specific inflammation led several immune cells. Among them, natural killer (NK) cells are emerging as important players development. Human NK CD56 and CD16 expression, which allows classifying into four subsets: 1) dim + or effector (NK eff ); 2) bright − regulatory reg 3) intermediate cells; 4) cells, whose function not well determined. Since...
In this article, I explore the ethical dimensions of same-sex reproduction achieved through epigenome editing—an innovative and transformative technique. For first time, analyse potential normativity disruptive approach for reproductive purposes, focusing on its implications lesbian couples seeking genetically related offspring. Epigenome editing offers a compelling solution to complex challenges posed by traditional gene editing, as it sidesteps genome modifications long-term genetic...
Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-producing cells. Due to ability apoptotic cells clearance induce tolerance, we previously generated liposomes rich in phophatidylserine (PS) -a feature cells- loaded with insulin peptides mimic beta-cells. PS-liposomes arrested autoimmunity experimental T1D through induction tolerance. The aim this study was investigate potential several from different autoantigens encapsulated (PS)-liposomes for prevention...
Type 1 diabetes is an autoimmune disease caused by the destruction of insulin-producing β-cells. An ideal immunotherapy should combine blockade response with recovery functional target cell mass. With aim to develop new therapies for type that could contribute β-cell mass restoration, a drug repositioning analysis based on systems biology was performed identify regenerative potential commercially available compounds. Drug strategy used identifying uses approved drugs are outside scope...
Type 1 diabetes (T1D) is prompted by defective immunological tolerance, an event in which dendritic cells (DCs) are crucial as immune response orchestrators. In fact, they contribute to maintaining tolerance self-antigens, but can also prompt immunogenic against them, leading autoimmunity. Countless factors potentially impact on the proper functionality of DCs, range from altered subset distribution, impaired phagocytic function abnormal gene expression. Moreover, T1D, metabolic...
In brief Two independent groups have reported the development of ‘artificial embryos’. Those are in vitro models made mouse embryonic stem cells, without need for egg or sperm, and grown ex utero requiring implantation. This system might open new venues bioethical research if human cells show ability to replicate this system. Abstract The recent publications 2022 reveal possibility obtaining embryos sperm. These embryos’ can recapitulate some stages – from neurulation organogenesis Synthetic...
Abstract Blunted first-phase insulin secretion and deficiency are indicators of β cell dysfunction diabetes manifestation. Therefore, insights into molecular mechanisms that regulate homeostasis might provide entry sites to replenish content restore function. Here, we identify the inhibitory receptor (inceptor; encoded by gene IIR/ELAPOR1 ) as an insulin-binding regulates stores lysosomal degradation. Using human induced pluripotent stem (SC)-derived islets, show IIR knockout (KO) results in...
Abstract Type 1 diabetes is an autoimmune disease caused by the destruction of insulin-producing β-cells. To revert type diabetes, suppression attack should be combined with a β-cell replacement strategy. It has been previously demonstrated that liraglutide, glucagon-like peptide-1 receptor agonist, restores mass in via α-cell transdifferentiation and neogenesis. We report here treatment liraglutide does not prevent spontaneous non-obese diabetic (NOD) mouse model, but it tends to reduce...
Abstract Non-genetic factors are crucial in the pathogenesis of type 1 diabetes (T1D), a disease caused by autoimmunity against insulin-producing β-cells. Exposure to medications prenatal period may influence immune system maturation, thus altering self-tolerance. Prenatal administration betamethasone –a synthetic glucocorticoid given women at risk preterm delivery– affect development T1D. It has been previously demonstrated that protects offspring from T1D nonobese diabetic (NOD) mice. The...
Type 1 diabetes (T1D) is an auto-immune disease characterized by the progressive destruction of insulin-producing pancreatic beta cells. While cells are target immune attack, other islet endocrine cells, namely alpha and delta can also be affected inflammatory milieu. Here, using a flow cytometry-based strategy, we compared impact IFNγ, one main cytokines involved in T1D, on three cell subsets isolated from C57BL/6 mouse islets. RNA-seq analyses revealed that exposed vitro to IFNγ display...
In this paper, we discuss the ethical concerns that may arise from synthesis of human DNA. To date, only small stretches DNA have been constructed, but prospect generating genomes is becoming feasible. At same time, significance genes for identity, health and reproduction coming under increased scrutiny. We examine implications its impact on debates over relationship with our ownership genes, potential to disrupt common understandings privacy, way in which synthetic challenges traditional...
<p dir="ltr">Murine pancreatic endocrinogenesis has been extensively studied, but human data remain scarce due to limited sample availability. Here, we first built a large collection of embryonic and fetal pancreases covering the trimester pregnancy explore endocrinogenesis. Using an experimental pipeline combining in toto staining, tissue clearing, light-sheet fluorescence microscopy, show that insulin<sup>+</sup>, glucagon<sup>+</sup>,...
<p dir="ltr">Murine pancreatic endocrinogenesis has been extensively studied, but human data remain scarce due to limited sample availability. Here, we first built a large collection of embryonic and fetal pancreases covering the trimester pregnancy explore endocrinogenesis. Using an experimental pipeline combining in toto staining, tissue clearing, light-sheet fluorescence microscopy, show that insulin<sup>+</sup>, glucagon<sup>+</sup>,...