A5074718722- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Childhood Cancer Survivors' Quality of Life
- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Immune Cell Function and Interaction
- Adolescent and Pediatric Healthcare
- Bone fractures and treatments
- Vascular Malformations Diagnosis and Treatment
- Total Knee Arthroplasty Outcomes
- Hip disorders and treatments
- Genetic Syndromes and Imprinting
- Health and Lifestyle Studies
- Intracranial Aneurysms: Treatment and Complications
- Metabolism and Genetic Disorders
- Ureteral procedures and complications
- Neurosurgical Procedures and Complications
- T-cell and Retrovirus Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Stress Responses and Cortisol
- Healthcare during COVID-19 Pandemic
- Cystic Fibrosis Research Advances
- Reproductive tract infections research
- Moyamoya disease diagnosis and treatment
Institute of Research and Innovation Parc Tauli
2021-2024
Universitat Autònoma de Barcelona
2013-2024
Corporació Sanitària Parc Taulí
2013-2024
Universidad Politécnica de Cartagena
2024
Instituto de Salud Carlos III
2021-2024
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2021
Government of Catalonia
2021
Deleted Institution
2013-2019
Hospital Universitario Fundación Jiménez Díaz
2018
Universidad Autónoma de Madrid
2018
Abstract Background Before the COVID-19 pandemic, Sexually transmitted infections (STIs) were increasing in Europe, and Spain Catalonia not an exception. has been one of regions with highest number confirmed cases Spain. The objective this study was to estimate magnitude decline, due STI during lockdown de-escalation phases. Methods Interrupted time series analysis performed decline reported - chlamydia, gonorrhoea, syphilis, lymphogranuloma venereum- since historical data, from March 13th...
The objective of the study was to describe baseline health-related quality life (HRQOL) in a cohort children and adolescents with type 1 diabetes mellitus (T1DM), analyze its associated clinical sociodemographic factors, assessing HRQOL through internet. This descriptive 136 patients T1DM from 5 hospitals Catalonia, Spain (72 girls, mean age 13.4 years (range 8–19). Inclusion criteria were more than 6 months diagnosis, 8 old without cognitive problems. Sociodemographic (age, sex, family...
Abstract Context Safety concerns have been raised regarding premature mortality, diabetes, neoplasia, and cerebrovascular disease in association with GH therapy. Objective To assess incidence of key safety outcomes. Design Prospective, multinational, observational study (1999 to 2015). Setting A total 22,311 GH-treated children from 827 investigative sites 30 countries. Patients Children growth disorders. Interventions treatment. Main outcome measures Standardized mortality ratio (SMR)...
Non-adherence to r-hGH treatments occurs in a variable percentage of subjects. One problem found when evaluating adherence is the great variability methods detection and definitions utilized studies. This study assessed level subjects receiving with easypod™ electronic device.National, multicenter, prospective observational involving 238 (144 GH deficiency (GHD), 86 small for gestational age (SGA), 8 Turner Syndrome), who received at least 3 months before inclusion. The follow-up period was...
Type 1 diabetes (T1D) is a chronic metabolic disease characterized by the autoimmune destruction of β-cells in pancreatic islets. T1D preceded islet-specific inflammation led several immune cells. Among them, natural killer (NK) cells are emerging as important players development. Human NK CD56 and CD16 expression, which allows classifying into four subsets: 1) dim + or effector (NK eff ); 2) bright − regulatory reg 3) intermediate cells; 4) cells, whose function not well determined. Since...
: To assess the impact of COVID-19 pandemic and lockdown measures on presenting characteristics (age at diagnosis, severity, monthly distribution) newly diagnosed type 1 diabetes in Spanish children.
The lack of continuity between health-related quality life (HRQoL) instruments designed for children and adults hinders change analysis with a course approach. To resolve this gap, EuroQol (EQ) developed the EQ-5D-Youth (EQ-5D-Y), derived from EQ-5D adults. Few studies have assessed metric properties EQ-5D-Y in specific chronic conditions, none done so type I diabetes mellitus (T1DM).This study aimed to evaluate acceptability, validity, reliability, responsiveness adolescents T1DM, when...
The partial remission (PR) phase, a period experienced by most patients with type 1 diabetes (T1D) soon after diagnosis, is characterized low insulin requirements and improved glycemic control. Given the great potential of this phase as therapeutic window for immunotherapies because its association immunoregulatory mechanisms β-cell protection, our objective was to find peripheral immunological biomarkers better characterization, monitoring, prediction. longitudinal follow-up 17 pediatric...
Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between expression and MCP-1 level found (r -0.649, 0.020), while no soluble biomarkers or cellular immune activation found.
Salt-losing crisis with hypoglycaemia and shock are the main manifestations of congenital adrenal hyperplasia (CAH) during first weeks life, while hyponatremia hyperpotassemia alone seen on mineralocorticoid deficiency or resistance. During neonatal period, high blood levels steroids may lead to confusing laboratory tests not being able identify real level each hormone. A 33-day-old male baby was admitted at emergency department severe salt-losing (Na + 99 mEq/l K 9.4 mEq/l) mild acidosis....
The partial remission (PR) phase of type 1 diabetes (T1D) is an underexplored period characterized by endogenous insulin production and downmodulated autoimmunity. To comprehend the mechanisms behind this transitory develop precision medicine strategies, biomarker discovery patient stratification are unmet needs. MicroRNAs (miRNAs) small RNA molecules that negatively regulate gene expression modulate several biological processes, functioning as biomarkers for many diseases. Here, we identify...
The success of micropropagation Limonium sinuatum depends on the establishment phase.The most suitable explant should be selected to ensure a good introduction laboratory conditions.This paper presents results tests carried out with four varieties different colours L. sinuatum, SN8946, SN9013, SN9000 and SN9001, using as starting material 5 x mm pieces taken from young leaves an alternative immature inflorescences.The explants were tested in treatments Murashige Skoog (MS) culture media...
Precursors of peptide hormones undergo posttranslational modifications within the trans-Golgi network (TGN). Dysfunction proteins involved at different steps this process cause several complex syndromes affecting central nervous system (CNS). We aimed to clarify genetic in a group patients characterized by hypopituitarism combination with brain atrophy, thin corpus callosum, severe developmental delay, visual impairment, and epilepsy.
Light plays an important role during the multiplication phase in vitro culture of Limonium sinuatum.Light intensity affects growth, rate and concentration pigments plants.This work presents behavioural results four L. sinuatum varieties different colours, SN8946, SN9013, SN9000 SN9001, subcultured on Murashige Skoog (MS) medium supplemented with N6 -benzyladenine (BA), subjected to three light treatments.The incident photosynthetically active radiation (PAR) was measured for each them, flow...
ntroduction : Autoimmune type 1 diabetes mellitus (T1D) is one of the most prevalent chronic diseases in paediatric age group. Gamification education may have potential to change health behaviours by creating an innovative, engaging and interactive learning environment. Material methods A 6-month prospective quasiexperimental pilot study aimed at evaluating impact a gamified educational intervention (own kahoot ®, face-to-face, 2 sessions, with immediate feedback) on knowledge, metabolic...
ResumenLos aneurismas disecantes que afectan de forma exclusiva a la arteria cerebelosa posteroinferior (PICA) son muy raros.Su manifestación clínica dependerá del lugar pared arterial en se produzca disección, produciendo hemorragia subaracnoidea (HSA) o bien oclusión vaso e isquemia.El diagnóstico aneurisma realiza el estudio angiográfico mostrándose como una dilatación fusiforme grados variables estrechamiento y vaso.La resonancia magnética (RM) puede ser gran ayuda detectando hematoma...
Background: This multicenter crossover study investigated the potential beneficial effect of an automated bolus calculator (ABC) in children and adolescents with type 1 diabetes (T1D) treated multiple daily injections (MDI). Methods: Participants were randomized to either begin or end a 5 months intervention versus their regular treatment regimen (control), separated by 2 washout period. During participants carefully instructed use ABC (Accu-Check Aviva Expert) manual insulin calculations...
The treatment of massive osteochondral defects in young patients constitutes a challenge for the orthopaedic surgeon. On one hand, facing biological filling and on other, guaranteeing function short long term. Defects lateral femoral condyle are extremely rare. We studied 7 cases bone condyle, 2 them bilateral, with median surface area 6.8 cm2 (IQR: 4.9−7.0 cm2) depth 2.8 cm (IQR; 2.2–3.2 cm). were between 17 21 years old, without any previous traumatic background treated autologous iliac...