A5036533821- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Prion Diseases and Protein Misfolding
- Nuclear Receptors and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- Neuroinflammation and Neurodegeneration Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Ion Transport and Channel Regulation
- Cancer Genomics and Diagnostics
- Diet and metabolism studies
- Immune Cell Function and Interaction
- Wnt/β-catenin signaling in development and cancer
- Platelet Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Attention Deficit Hyperactivity Disorder
- 14-3-3 protein interactions
- Bipolar Disorder and Treatment
- Protein Degradation and Inhibitors
- Colorectal Cancer Treatments and Studies
- Advanced Glycation End Products research
- Amyotrophic Lateral Sclerosis Research
- Genomics, phytochemicals, and oxidative stress
Anaxomics (Spain)
2010-2023
Hospital Del Mar
2018
Texas Endosurgery Institute
2013
Institute for Neurodegenerative Disorders
2013
Hospital de Sant Pau
2008-2011
Massachusetts General Hospital
2010-2011
Harvard University
2010-2011
Universitat Autònoma de Barcelona
2009-2011
Biomedical Research Networking Center on Neurodegenerative Diseases
2009
Universitat Pompeu Fabra
2005-2009
Whereas amyloid-β (Aβ) accumulates in the brain of normal animals dosed with low levels copper (Cu), mechanism is not completely known. Cu could contribute to Aβ accumulation by altering its clearance and/or production. Because homeostasis altered transgenic mice overexpressing precursor protein (APP), objective this study was elucidate Cu-induced brains and then explore Cu's effects a mouse model Alzheimer's disease. In aging mice, capillaries associated reduction low-density lipoprotein...
A key event in the pathogenesis of Alzheimer’s disease (AD) is accumulation amyloid-β (Aβ) species brain, derived from sequential cleavage amyloid precursor protein (APP) by β- and γ-secretases. Based on a systems biology study to repurpose drugs for AD, we explore effect lansoprazole, other proton-pump inhibitors (PPIs), Aβ production AD cellular animal models. We found that lansoprazole enhances Aβ37, Aβ40 Aβ42 lowers Aβ38 levels cell Interestingly, acute treatment wild type transgenic...
It has long been assumed that β-amyloid (Aβ) had to assemble into fibrillar amyloid plaques exert its neurotoxic effects in Alzheimer disease. An alternative hypothesis is soluble oligomers ofAβ play a much larger role neuronal damage than the insoluble component. We have tested these competing hypotheses vivo by studying clinicopathologic correlates of oligomeric Aβ species and classic brains double-transgenic APP-tau mice up 17 months age. Biochemical immunohistochemical measures brain...
Voltage-dependent K+ channels (VDPC) are expressed in most mammalian cells and involved the proliferation activation of lymphocytes. However, role VDPC macrophage responses is not well established. This study was undertaken to characterize macrophages determine their physiological during activation. Macrophages proliferate until an endotoxic shock halts cell growth they become activated. By inducing a schedule that similar pattern, we have identified non-transformed bone marrow-derived...
Alzheimer's disease neuropathology is characterized by neuronal death, amyloid beta-peptide deposits and neurofibrillary tangles composed of paired helical filaments tau protein. Although crucial for our understanding the pathogenesis disease, molecular mechanisms linking remain unknown. Here, we show that beta-peptide-induced nitro-oxidative damage promotes nitrotyrosination glycolytic enzyme triosephosphate isomerase in human neuroblastoma cells. Consequently, nitro-triosephosphate was...
From January 2020, COVID-19 is spreading around the world producing serious respiratory symptoms in infected patients that some cases can be complicated by severe acute syndrome, sepsis and septic shock, multiorgan failure, including kidney injury cardiac injury. Cost time efficient approaches to reduce burthen of disease are needed. To find potential treatments among whole arsenal existing drugs, we combined system biology artificial intelligence-based approaches. The drug combination...
Here we used a systems biology approach and artificial intelligence to identify neuroprotective agent for the treatment of peripheral nerve root avulsion. Based on accumulated knowledge neurodegenerative processes that occur in motoneurons after avulsion, built up protein networks converted them into mathematical models. Unbiased proteomic data from our preclinical models were machine learning algorithms restrictions be imposed solutions. Solutions allowed us combinations repurposed drugs as...
It has been suggested that cellular cholesterol levels can modulate the metabolism of amyloid precursor protein (APP) but underlying mechanism remains controversial. In current study, we investigate in detail relationship between reduction, APP processing and gamma-secretase function cell culture studies. We found mild membrane reduction led to a decrease Abeta(40) Abeta(42) different types. did not detect changes intracellular domain or Notch generation. Western blot analyses showed...
We report the clinical, pathologic, and biochemical characteristics of recently described amyloid precursor protein (APP) I716F mutation. present clinical findings individuals carrying APP mutation neuropathologic examination proband. The was found in a patient with Alzheimer disease onset at age 31 years death 36 who had positive family history early-onset disease. Neuropathologic showed abundant diffuse plaques mainly composed amyloid-beta42 widespread neurofibrillary pathology. Lewy...
Perceived age has been defined as the that a person is visually estimated to be on basis of physical appearance. In society where youthful appearance are an object desire for consumers, and source commercial profit cosmetic companies, this concept prominent role. addition, perceived also indicator overall health status in elderly people, since old-looking people tend show higher rates morbidity mortality. However, there lack objective methods quantifying age.In order satisfy need approaches...
Abstract Background Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) are manifestations of an autoinflammatory disorder with complex pathophysiology significant morbidity, together also termed disease. The objective the current study is to set in silico models based on systems biology investigate optimal treat-to-target strategy for as a proof-of-concept modeling approach. Methods Molecular characteristics data biological inhibitors interleukin (IL)-1...
Amyotrophic Lateral Sclerosis is a fatal, progressive neurodegenerative disease characterized by loss of motor neuron function for which there no effective treatment. One the main difficulties in developing new therapies lies on multiple events that contribute to death amyotrophic lateral sclerosis. Several pathological mechanisms have been identified as underlying process, including excitotoxicity, mitochondrial dysfunction, oxidative stress, altered axonal transport, proteasome synaptic...
// Enric Carcereny 1 , Alonso Fernández-Nistal 2 Araceli López Carmen Montoto Andrea Naves Cristina Segú-Vergés 3 Mireia Coma Guillem Jorba 4 Baldomero Oliva and Jose Manuel Mas Catalan Institute of Oncology B-ARGO Group, Hospital Germans Trias i Pujol, Badalona, Spain Takeda Farmacéutica España, Madrid, Anaxomics Biotech, Barcelona, Structural Bioinformatics (GRIB-IMIM), Departament de Ciències Experimentals la Salut, Universitat Pompeu Fabra, Correspondence to: Carcereny, email:...
Amyloid β-peptide (Aβ) cytotoxicity, the hallmark of Alzheimer's disease, implicates oxidative stress in both neurons and vascular cells, particularly endothelial cells. Consequently, antioxidants have shown neuroprotective activities against Aβ-induced cytotoxicity. Among different used vitro vivo studies, 17β-oestradiol (E2) has garnered most attention. Oestrogen attenuated AβE22Q-induced toxicity but failed to protect Here we show that E2-mediated activation nitric oxide synthase (eNOS)...
Type 1 diabetes is an autoimmune disease caused by the destruction of insulin-producing β-cells. An ideal immunotherapy should combine blockade response with recovery functional target cell mass. With aim to develop new therapies for type that could contribute β-cell mass restoration, a drug repositioning analysis based on systems biology was performed identify regenerative potential commercially available compounds. Drug strategy used identifying uses approved drugs are outside scope...
The prevalence of type 2 diabetes is increasing worldwide, accounting for 85-95% all diagnosed cases diabetes. Clinical trials provide evidence benefits low-carbohydrate ketogenic diets in terms clinical outcomes on patients. However, the molecular events responsible these improvements still remain unclear spite high amount knowledge primary mechanisms both and metabolic state ketosis. Molecular network analysis conditions, diseases treatments might new insights help build a better...
Eltrombopag is a thrombopoietin receptor (MPL) agonist approved for the treatment of primary immune thrombocytopenia (ITP). Recent evidence shows that some patients may sustain platelet counts following eltrombopag discontinuation. The systemic immunomodulatory response resolves ITP in could result from an increase mass, caused either by direct action on megakaryocytes through MPL stimulation, or potential MPL-independent actions other cell types. To uncover possible mechanisms eltrombopag,...
TNF‐α, generated during the systemic inflammatory response, triggers a wide range of biological activities that mediate neurologic manifestations associated with cancer and infection. Since this cytokine regulates ion channels in vitro (especially Kv1.3 Kir2.1), we aimed to study Kir2.1 expression brain response vivo inflammation. Cancer‐induced cachexia LPS administration increased plasma TNF‐α. was impaired cachexia. However, treatment induced downregulated expression, TNF‐α mimicked these...
Real-world studies are needed to identify factors associated with response biologic therapies in patients axial spondyloarthritis (SpA). The objective was assess sex differences tumor necrosis factor inhibitors (TNFi) and explore possible risk TNFi efficacy.A total of 969 SpA (315 females, 654 males) enrolled the BIOBADASER registry (2000-2019) who initiated a (first, second, or further lines) were studied. Statistical artificial intelligence (AI)-based data analyses used association other...