A5006867583- Cancer Cells and Metastasis
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Angiogenesis and VEGF in Cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Metastasis and carcinoma case studies
- Mechanisms of cancer metastasis
- Axon Guidance and Neuronal Signaling
- PI3K/AKT/mTOR signaling in cancer
- Muscle Physiology and Disorders
- Neuroendocrine Tumor Research Advances
- Receptor Mechanisms and Signaling
- Exercise and Physiological Responses
- Immune cells in cancer
- Respiratory Support and Mechanisms
- Pancreatic function and diabetes
- Proteoglycans and glycosaminoglycans research
- Endoplasmic Reticulum Stress and Disease
- HER2/EGFR in Cancer Research
- Autophagy in Disease and Therapy
- Muscle metabolism and nutrition
- Neuropeptides and Animal Physiology
- Cancer-related gene regulation
Universitat de Barcelona
2013-2024
Universitat de Vic - Universitat Central de Catalunya
2020-2024
Institute for Radiological Image Sciences
2024
Institut de Biomedicina de la Universitat de Barcelona
2024
Hospital Regional Universitario de Málaga
2021-2023
Institute for Research in Biomedicine
2021
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2013-2020
Fondazione IRCCS Istituto Nazionale dei Tumori
2016
Hospital Clínic de Barcelona
2013-2016
Centro de Investigación Biomédica en Red
2010-2015
This article introduces the second release of Gypsy Database Mobile Genetic Elements (GyDB 2.0): a research project devoted to evolutionary dynamics viruses and transposable elements based on their phylogenetic classification (per lineage protein domain). The (GyDB) is long-term that continuously progressing, owing high molecular diversity mobile requires be completed in several stages. GyDB 2.0 has been powered with wiki allow other researchers participate project. current database stage...
Abstract Purpose: Despite the therapeutic success of existing HER2-targeted therapies, tumors invariably relapse. This study aimed at identifying new mechanisms responsible for therapy resistance. Experimental Design: We have used a platform therapy–resistant cell lines and primary cultures healthy tumor-associated fibroblasts (TAF) to identify potential targets related tumor escape from anti-HER2 therapies. Results: shown that TAFs promote resistance produce secrete high levels FGF5, which...
Voltage-dependent K+ channels (VDPC) are expressed in most mammalian cells and involved the proliferation activation of lymphocytes. However, role VDPC macrophage responses is not well established. This study was undertaken to characterize macrophages determine their physiological during activation. Macrophages proliferate until an endotoxic shock halts cell growth they become activated. By inducing a schedule that similar pattern, we have identified non-transformed bone marrow-derived...
Abstract In cancer cachexia both cardiac and skeletal muscle suffer an important protein mobilization as a result of increased proteolysis. Administration the β2-agonist formoterol to rats mice bearing highly cachectic tumors resulted in reversal muscle-wasting process. The anti-wasting effects drug were based on activation rate synthesis inhibition Northern blot analysis revealed that treatment decrease mRNA content ubiquitin proteasome subunits gastrocnemius muscles; this, together with...
Survivors of critical illness often have significant long-term brain dysfunction, and routine clinical procedures like mechanical ventilation (MV) may affect outcome. We aimed to investigate the effect increase tidal volume (Vt) on activation in a rat model. Male Sprague Dawley rats were randomized three groups: 1) Basal: anesthetized unventilated animals, 2) low Vt (LVt): MV for hours with 8 ml/kg zero positive end-expiratory pressure (ZEEP), 3) high (HVt) 30 ZEEP. measured lung mechanics,...
Abstract ERBB receptor transmodulation by heterologous G-protein–coupled receptors (GPCR) generates functional diversity in signal transduction. Tachykinins are neuropeptides and proinflammatory cytokines that promote cell survival cancer progression activating several GPCRs. In this work, we found the pain-associated tachykinin Substance P (SP) contributes to persistent of receptors, EGFR HER2, breast cancer, acting enhance malignancy therapeutic resistance. SP its high-affinity NK-1R were...
Abstract Purpose: ABTL0812 is a novel first-in-class, small molecule which showed antiproliferative effect on tumor cells in phenotypic assays. Here we describe the mechanism of action this antitumor drug, currently clinical development. Experimental Design: We investigated cancer cell death, proliferation, and modulation intracellular signaling pathways, using human lung (A549) pancreatic (MiaPaCa-2) xenografts. To identify cellular targets, performed silico high-throughput screening...
Histamine receptor 1 (HRH1) belongs to the rhodopsin-like G-protein-coupled family. Its activation by histamine triggers cell proliferation, embryonic development, and tumor growth. We recently established that HRH1 is up-regulated in basal human epidermal growth factor 2 (HER2)-enriched breast tumors its expression correlates with a worse prognosis. Nevertheless, functional role of HER2-targeted therapy-resistant cancer (BC) progression has not yet been addressed. Using terfenadine,...
Abstract The tumor-promoting fibrotic stroma rich in tumor-associated fibroblasts (TAF) is drawing increased therapeutic attention. Intriguingly, a trial with the antifibrotic drug nintedanib non–small cell lung cancer reported clinical benefits adenocarcinoma (ADC) but not squamous carcinoma (SCC), even though both histotypes. Likewise, we that inhibited phenotype of TAFs selectively ADC. Here show tumor fibrosis actually higher ADC-TAFs than SCC-TAFs vitro and patient samples....
Interleukin-15 (IL-15) plays an important role in lipid metabolism as its administration to rats causes a marked depletion of white adipose tissue (WAT). This reduction fat mass seems be caused by and related hipotriglyceridemia result lower hepatic lipogenesis increased fatty acid oxidation. We have previously observed that IL-15 treatment induces the expression uncoupling proteins (UCPs) muscle. The aim this study was investigate effects on brown (BAT), particular genes tissue.Male Wistar...
Two lineages, epithelial, and myoepithelial cells are the main cell populations in normal mammary gland breast cancer. Traditionally, cancer research has been performed using commercial lines, but primary cultures obtained from fresh tissue a powerful tool to study more reliably new aspects of biology, including pathological conditions. Nevertheless, methods described date have some technical problems terms viability yield, which hamper work with cells. Therefore, there is need optimize...
Abstract Implantation of the Yoshida AH-130 ascites hepatoma to rats resulted in a decrease muscle weight 7 days after inoculation tumor. These changes were associated with increases mRNA content for both peroxisome proliferator-activated receptor (PPAR) γ and PPARδ skeletal muscle. The increase gene expression these transcription factors was related several genes involved fatty acid transport, activation, oxidation. Tumor burden also PPARγ coactivator-1α pyruvate dehydrogenase kinase 4. All...
Abstract Interleukin‐15 (IL‐15) is an anabolic factor for skeletal muscle and several reports have described its important role as a regulator of energy homeostasis. In this study, we analyzed the effects IL‐15 on adipocyte differentiation using 3T3‐L1 preadipose cell line. The data show that tends to reduce rate proliferation, induces apoptosis, partially stops differentiation. signaling molecules behind these actions cytokine adipose cells are: p42/p44 MAPK (which seem be associated with...
Acute lung injury (ALI) is a clinical manifestation of respiratory failure, caused by inflammation and the disruption alveolar-capillary barrier. Preservation physical integrity alveolar epithelial monolayer critical importance to prevent edema. Barrier depends largely on balance between forces cell-cell cell-matrix contacts, this might be affected alterations in coagulation cascade patients with ALI. We aimed study effects activated protein C (APC) mechanical tension barrier human cells...
Around 40% of newly diagnosed lung cancer patients are Stage IV, where the improvement survival and reduction disease-related adverse events is main goal for oncologists. In this scenario, we present preclinical evidence supporting use ABTL0812 in combination with chemotherapy treating advanced metastatic Nonsmall cell adenocarcinomas (NSCLC) squamous carcinomas. a new chemical entity, currently Phase 1b/2a clinical trial NSCLC paclitaxel carboplatin (P/C), after successfully completing...
// Roberto Lugo 1 , Marta Gabasa Francesca Andriani 2 Puig 1, 3 Federica Facchinetti Josep Ramírez 4 Abel Gómez-Caro 5 Ugo Pastorino 6 Gemma Fuster 6, 7 Isaac Almendros Pere Gascón 3, Albert Davalos 8 Noemí Reguart Luca Roz Jordi Alcaraz 9 Unit of Biophysics and Bioengineering, Department Biomedicine, School Medicine, Universitat de Barcelona, Spain Tumor Genomics Unit, Experimental Oncology Molecular Fondazione IRCCS Istituto Nazionale dei Tumori INT, Milano,...