A5022495007- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Anesthesia and Sedative Agents
- Neonatal Respiratory Health Research
- Anesthesia and Neurotoxicity Research
- Family and Patient Care in Intensive Care Units
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mechanical Circulatory Support Devices
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Non-Invasive Vital Sign Monitoring
- Long-Term Effects of COVID-19
- Airway Management and Intubation Techniques
- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- Vagus Nerve Stimulation Research
- Thermal Regulation in Medicine
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
- Healthcare Technology and Patient Monitoring
- EEG and Brain-Computer Interfaces
- Healthcare professionals’ stress and burnout
- Magnetic and Electromagnetic Effects
- S100 Proteins and Annexins
Universitat Autònoma de Barcelona
2015-2025
Institute of Research and Innovation Parc Tauli
2015-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2014-2025
Instituto de Salud Carlos III
2015-2025
Corporació Sanitària Parc Taulí
2013-2024
Deleted Institution
2004-2018
Centro de Investigación Biomédica en Red
2015
Ospedale di Cattinara
2009
Jacobson Holman (United States)
2005-2006
St. Joseph’s Healthcare Hamilton
2005
Intensive Care Unit (ICU) COVID-19 survivors may present long-term cognitive and emotional difficulties after hospital discharge. This study aims to characterize the neuropsychological dysfunction of 12 months ICU discharge, whether use a measure perceived deficit allows detection objective impairment. We also explore relationship between demographic, clinical factors, both subjective deficits.Critically ill from two medical ICUs underwent assessment one year The perception state was...
Abstract Background Flow starvation is a type of patient-ventilator asynchrony that occurs when gas delivery does not fully meet the patients’ ventilatory demand due to an insufficient airflow and/or high inspiratory effort, and it usually identified by visual inspection airway pressure waveform. Clinical diagnosis cumbersome prone underdiagnosis, being opportunity for artificial intelligence. Our objective develop supervised intelligence algorithm identifying deformation during square-flow...
Survivors of critical illness often have significant long-term brain dysfunction, and routine clinical procedures like mechanical ventilation (MV) may affect outcome. We aimed to investigate the effect increase tidal volume (Vt) on activation in a rat model. Male Sprague Dawley rats were randomized three groups: 1) Basal: anesthetized unventilated animals, 2) low Vt (LVt): MV for hours with 8 ml/kg zero positive end-expiratory pressure (ZEEP), 3) high (HVt) 30 ZEEP. measured lung mechanics,...
Double cycling generates larger than expected tidal volumes that contribute to lung injury. We analyzed the incidence, mechanisms, and physiologic implications of double during volume- pressure-targeted mechanical ventilation in critically ill patients.Prospective, observational study.Three general ICUs Spain.Sixty-seven continuously monitored adult patients undergoing volume control-continuous mandatory with constant flow, decelerated or pressure for longer 24 hours.None.We 9,251 hours...
Objective: To assess the influence of massive brain injury on pulmonary susceptibility to attending subsequent mechanical or ischemia/reperfusion stress. Design: Prospective experimental study. Setting: Animal research laboratory. Subjects: Twenty-four anesthetized New Zealand White rabbits randomized control (n = 12) induced group. Interventions: After randomization, was by inflation an intracranial balloon-tipped catheter, and animals were ventilated with a tidal volume 10 mL/kg zero...
The aim of the study was to analyse effects positive end-expiratory pressure (PEEP) on volumetric capnography and respiratory system mechanics in mechanically ventilated patients. Eight normal subjects (control group), nine patients with moderate acute lung injury (ALI group) eight distress syndrome (ARDS were studied. Respiratory mechanics, alveolar ejection volume as a fraction tidal (VAE/VT), phase III slopes expired CO2 beyond VAE Bohr's dead space (VD/VT(Bohr)) at different levels PEEP...
Oxygen therapy is currently used as a supportive treatment in septic patients to improve tissue oxygenation. However, oxygen can exert deleterious effects on the inflammatory response triggered by infection. We postulated that use of high concentrations may be partially responsible for worsening sepsis-induced multiple system organ dysfunction an experimental clinically relevant model sepsis. Sprague-Dawley rats. Sepsis was induced cecal ligation and puncture. Sham-septic controls (n = 16)...
The mechanisms of lung repair and fibrosis in the acute respiratory distress syndrome (ARDS) are poorly known. Since role WNT/β-catenin signaling appears to be central healing fibrosis, we hypothesized that this pathway is activated very early lungs after sepsis.We tested our hypothesis using a three-step experimental design: (1) vitro cell injury model with human bronchial epithelial BEAS-2B fibroblasts (MRC-5) cells exposed endotoxin for 18 hours; (2) an animal sepsis-induced ARDS induced...
Growing evidence suggests that critical illness often results in significant long-term neurocognitive impairments one-third of survivors. Although these are long-lasting and devastating for survivors, rehabilitation rarely occurs during or after illness. Our aim is to describe an early stimulation intervention based on virtual reality patients who critically ill present the a proof-of-concept study testing feasibility, safety, suitability this intervention.Twenty adult undergoing having...
Abstract In mechanical ventilation, it is paramount to ensure the patient’s ventilatory demand met while minimizing asynchronies. We aimed develop a model predict likelihood of asynchronies occurring. analyzed 10,409,357 breaths from 51 critically ill patients who underwent ventilation >24 h. Patients were continuously monitored and common identified regularly indexed. Based on discrete time-series data representing total count asynchronies, we defined four states or levels risk z1...
In critically ill patients, poor patient-ventilator interaction may worsen outcomes. Although sedatives are often administered to improve comfort and facilitate ventilation, they can be deleterious. Whether opioids asynchronies with fewer negative effects is unknown. We hypothesized that alone would result in more wakeful patients than or sedatives-plus-opioids. This prospective multicenter observational trial enrolled adults mechanically ventilated (MV) > 24 h. compared sedation depth...
Abstract Background ICU patients undergoing invasive mechanical ventilation experience cognitive decline associated with their critical illness and its management. The early detection of different phenotypes might reveal the involvement diverse pathophysiological mechanisms help to clarify role precipitating predisposing factors. Our main objective is identify in critically ill survivors 1 month after discharge using an unsupervised machine learning method, contrast them classical approach...
Objective: To evaluate the influence of vascular flow on ventilator-induced lung injury independent pressures. Design: Laboratory study. Setting: Hospital laboratory. Subjects: Thirty-two New Zealand White rabbits. Interventions: isolated perfused rabbit lungs were allocated into four groups: low flow/low pulmonary capillary pressure; high flow/high pressure, and pressure. All ventilated with peak airway pressure 30 cm H2O positive end-expiratory 5 for mins. Measurements Main Results:...
This study focuses on the application of a non-immersive virtual reality (VR)-based neurocognitive intervention in critically ill patients. Our aim was to assess feasibility direct outcome measures detect impact this digital therapy patients' cognitive and emotional outcomes. Seventy-two mechanically ventilated adult patients were randomly assigned "treatment as usual" (TAU, n = 38) or "early stimulation" (ENRIC, 34) groups. All received standard intensive care unit (ICU) care. Patients...