A5079996061- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Tissue Engineering and Regenerative Medicine
- Cancer, Hypoxia, and Metabolism
- Respiratory Support and Mechanisms
- Sleep and Wakefulness Research
- Adipose Tissue and Metabolism
- Neonatal Respiratory Health Research
- Electrospun Nanofibers in Biomedical Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Cardiovascular and Diving-Related Complications
- Fibroblast Growth Factor Research
- Tracheal and airway disorders
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
- High Altitude and Hypoxia
- Extracellular vesicles in disease
- Immune cells in cancer
- Cardiovascular Disease and Adiposity
- Gut microbiota and health
- Cardiovascular Function and Risk Factors
Universitat de Barcelona
2015-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2014-2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2015-2024
Departament de Salut
2017-2022
Instituto de Salud Carlos III
2017-2022
Centro de Investigación Biomédica en Red
2016-2021
Institut Català de Nanociència i Nanotecnologia
2021
Institut de Nanociència i Nanotecnologia de la Universitat de Barcelona
2021
Zero to Three
2020
Centre for Biomedical Network Research on Rare Diseases
2016-2019
Abstract Chronic sleep fragmentation (SF) commonly occurs in human populations, and although it does not involve circadian shifts or deprivation, markedly alters feeding behaviors ultimately promoting obesity insulin resistance. These symptoms are known to be related the host gut microbiota. Mice were exposed SF for 4 weeks then allowed recover 2 weeks. Taxonomic profiles of fecal microbiota obtained prospectively, conventionalization experiments performed germ-free mice. Adipose tissue...
El objetivo principal de este documento internacional consenso sobre apnea obstructiva del sueño es proporcionar unas directrices que permitan a los profesionales sanitarios tomar las mejores decisiones en la asistencia pacientes adultos con esta enfermedad según un resumen crítico literatura más actualizada. grupo trabajo expertos se ha constituido principalmente por 17 sociedades científicas y 56 especialistas amplia representación geográfica (con participación 4 internacionales), además...
An increased cancer aggressiveness and mortality have been recently reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), a hallmark of OSA, enhances melanoma growth metastasis in mice.
Abstract Sleep fragmentation (SF) is a highly prevalent condition and hallmark of sleep apnea, that has been associated with increased cancer incidence mortality. In this study, we examined the hypothesis promotes tumor growth progression through proinflammatory TLR4 signaling. design, compared mice were exposed to one week before engraftment syngeneic TC1 or LL3 cells analysis four weeks later. We also host contributions use genetically deficient in its effector molecules MYD88 TRIF. found...
Evidence from patients and animal models suggests that obstructive sleep apnea (OSA) may increase the risk of Alzheimer's disease (AD) AD is associated with reduced brain tissue stiffness.To investigate whether intermittent hypoxia (IH) alters cortex stiffness in mutant mice exposed to IH mimicking OSA.Six-eight month old (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J) wild-type (WT) littermates were subjected (21% O2 40 s 5% 20 s; 6 h/day) or normoxia for 8 weeks. After euthanasia, (E) 200-μm slices was...
Obstructive sleep apnoea (OSA) is associated with higher cancer incidence, tumour aggressiveness and mortality, as well greater severity of infections, which have been attributed to an immune deregulation. We studied the expression programmed cell death (PD)-1 receptor its ligand (PD-L1) on cells from patients OSA, consequences immune-suppressing activity. report that PD-L1 was overexpressed monocytes PD-1 CD8 + T-cells in a severity-dependent manner. overexpression were induced both human...
Intermittent hypoxia (IH) mimicking obstructive sleep apnea (OSA) significantly modifies gut microbiota in mice. However, whether these IH-induced microbiome changes are reversible after restoring normal oxygenation (the equivalent of effective OSA therapy) is unknown. The aim this study was to investigate composition and circulating endotoxemia a post-IH normoxic period mouse model OSA. Ten mice were subjected IH (40 sec 21% O2-20 5% O2) for 6 h/day w 10 breathing air (NM) used as controls....
Abstract Cell response to force regulates essential processes in health and disease. However, the fundamental mechanical variables that cells sense respond remain unclear. Here we show rate of application (loading rate) drives mechanosensing, as predicted by a molecular clutch model. By applying dynamic regimes through substrate stretching, optical tweezers, atomic microscopy, find increasing loading rates trigger talin-dependent leading adhesion growth reinforcement, YAP nuclear...
Gut microbiota (GM) contribute to obesity and insulin resistance (IR). Obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), promotes IR alters GM. Since circulating exosomes are implicated in IR, we examined the effects of IH physical activity (PA) mice on GM, colonic epithelium permeability, systemic plasma exosome cargo, visceral white adipose tissues (vWAT) IR.C57BL/6 were exposed or room air (RA) for 6 weeks with without PA (n = 12/group), GM changes assessed, as...
Intravascular neutrophils and platelets collaborate in maintaining host integrity, but their interaction can also trigger thrombotic complications. We report here that cooperation between neutrophil platelet lineages extends to the earliest stages of formation by megakaryocytes bone marrow. Using intravital microscopy, we show "plucked" intravascular megakaryocyte extensions, termed proplatelets, control production. Following CXCR4-CXCL12-dependent migration towards perisinusoidal...
To test the hypotheses that dynamic changes in brain oxygen partial pressure (PtO(2)) response to obstructive apneas or intermittent hypoxia differ from those other organs and PtO(2) is a source of oxidative stress.Prospective controlled animal study.University laboratory.98 Sprague-Dawley rats.Cerebral cortex, skeletal muscle, visceral fat tissues were exposed anesthetized animals subjected either (apneic hypoxic events 15 s each 60 events/h) for 1 h.Arterial saturation (SpO(2)) presented...
Angiogenesis, a process induced by hypoxia in visceral white adipose tissues (vWAT) the context of obesity, mediates obesity-induced metabolic dysfunction and insulin resistance. Chronic intermittent (IH) sustained (SH) induce body weight reductions resistance different magnitudes, suggesting inducible factor (HIF)-1α-related activity. Eight-week-old male C57BL/6J mice (n = 10-12/group) were exposed to either IH, SH, or room air (RA). vWAT analyzed for sensitivity (phosphorylated...
In January 2019, a European Respiratory Society research seminar entitled "Targeting the detrimental effects of sleep disturbances and disorders" was held in Dublin, Ireland. It provided opportunity to critically review current evidence pathophysiological responses disturbances, such as deprivation, fragmentation or circadian misalignment abnormalities physiological gases oxygen carbon dioxide, which occur frequently respiratory conditions during sleep. A specific emphasis placed on...
Three-dimensional printing is revolutionizing the development of scaffolds due to their rapid-prototyping characteristics. One most used techniques fused filament fabrication (FFF), which fast and compatible with a wide range polymers, such as PolyLactic Acid (PLA). Mechanical properties 3D printed polymeric are often weak for certain applications. A potential solution composite materials. In present work, metal-PLA composites have been tested material scaffolds. Three different materials...
Decellularization procedures have been developed and optimized for the entire organ or tissue blocks, by either perfusion of decellularizing agents through tissue's vasculature submerging large sections in solutions. However, some research aims require analysis native as well decellularized slices side side, but an optimal protocol has not yet established to address this need. Thus, main goal work was develop a fast efficient decellularization method slices-with emphasis on lung-while...
To test a cell model of snoring-induced airway inflammation and to assess whether vibration stimulus simulating the one experienced by tissues in snoring patients induces epithelial cells. Prospective controlled study culture. University laboratory. Human bronchial cells (BEAS-2B line). Cell cultures were subjected (60 Hz, ± 0.3 mm) for time periods 6 hours, 12 24 hours. The vibratory was applied with without treatment inhibitors 3 main pathways mitogen-activated protein kinases (MAPK): p38,...