A5030313841- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Cardiovascular and Diving-Related Complications
- Sleep and related disorders
- Tracheal and airway disorders
- Sleep and Wakefulness Research
- Venous Thromboembolism Diagnosis and Management
- Respiratory Support and Mechanisms
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Neonatal Respiratory Health Research
- Cardiovascular Disease and Adiposity
- Head and Neck Cancer Studies
- Atrial Fibrillation Management and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Alcohol Consumption and Health Effects
- Gestational Diabetes Research and Management
- Asthma and respiratory diseases
- Cardiac Valve Diseases and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Emergency and Acute Care Studies
- Fatty Acid Research and Health
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Sleep and Work-Related Fatigue
Health Research Institute of the Balearic Islands
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2013-2025
Instituto de Salud Carlos III
2008-2025
Hospital Universitario Son Espases
2016-2025
Universitat de les Illes Balears
2024-2025
Diego Portales University
2022
Universidad Bernardo O'Higgins
2022
University of the Americas
2022
Consorci Sanitari de Terrassa
2016
Garrahan Hospital
2012-2015
Continuous positive airway pressure (CPAP) is the first-line treatment for patients with symptomatic obstructive sleep apnea (OSA). However, its indication all sleep-disordered breathing, regardless of daytime symptoms, unclear.To evaluate effect CPAP on incidence hypertension or cardiovascular events in a cohort nonsleepy OSA.Multicenter, parallel-group, randomized controlled trial 14 teaching hospitals Spain. Between May 2004 and 2006, 725 consecutive were enrolled who had an...
for the Spanish
Rationale: Continuous positive airway pressure (CPAP) is the current treatment for patients with symptomatic obstructive sleep apnea (OSA). Its use all subjects sleep-disordered breathing, regardless of daytime symptoms, unclear.Objectives: This multicenter controlled trial assesses effects 1 year CPAP on blood (BP) in nonsymptomatic, hypertensive OSA.Methods: We evaluated 359 OSA. Inclusion criteria consisted an apnea–hypopnea index (AHI) greater than 19 hour−1, Epworth Sleepiness Scale...
Barbé, Ferran*†; Durán-Cantolla, Joaquín†‡; Sánchez de la Torre, Manuel*†; Martínez-Alonso, Montserrat*; Carmona, Carmen§; Barceló, Antonia†∥; Chiner, Eusebi¶; Masa, Juan F.#†; Gonzalez, Mónica**†††; Marín, Jose M.†††; Garcia-Rio, Francisco‡‡; Atauri, Josefa Diaz**; Terán, Joaquín†§§; Mayos, Mercedes†∥∥; Peña, Mónica†¶; Monasterio, Carmen†¶¶; del Campo, Felix##; Montserrat, Josep M.†*** for the Spanish Sleep and Breathing Network Author Information
Obstructive sleep apnea (OSA) has been associated with increased cancer mortality, but whether it is also incidence unknown.To investigate OSA in a large clinical cohort.A multicenter, cohort study including consecutive patients investigated for suspected between 2003 and 2007 seven Spanish teaching hospitals. Apnea-hypopnea index (AHI) percent nighttime oxygen saturation less than 90% (TSat(90)) were used as surrogates of severity, both continuous variables categorized by tertiles. Cox...
To assess the effect of continuous positive airway pressure (CPAP) on 24 hour ambulatory blood monitoring values in a large number patients with untreated systemic hypertension new onset and obstructive sleep apnoea.Multicentre, double blind, randomised, placebo controlled trial.Eleven general hospitals Spain between 2004 2007.340 recently diagnosed as having by practitioner (systolic ≥140 mm Hg, diastolic ≥90 or both) an apnoea-hypopnoea index per >15 events/hour.Patients were assigned to...
The aim of the present study was to assess impact nasal continuous positive airway pressure (nCPAP) in ischaemic stroke patients followed for 2 yrs. Stroke with an apnoea–hypopnoea index ≥20 events·h −1 were randomised early nCPAP (n = 71; 3–6 days after onset) or conventional treatment 69). Barthel Index, Canadian Scale, Rankin Scale and Short Form-36 measured at baseline, 1, 3, 12 24 months. percentage neurological improvement 1 month significantly higher group (Rankin scale 90.9 versus...
Excessive daytime sleepiness (EDS) is not invariably present in patients with obstructive sleep apnoea syndrome (OSAS). The aim of the study was to investigate polysomnographic determinants EDS OSAS. assessed using Epworth Sleepiness Scale (ESS) and multiple latency test (MSLT). Patients showed whenever ESS score >10 MSLT <5 min. Absence defined as having an <10 In total, 23 male (mean± sd 17±3 4±1 min, respectively) 17 without (ESS 5±2 16±3 respectively), were studied. Both groups...
The episodes of hypoxia/re-oxygenation associated with the respiratory disturbances observed in patients obstructive sleep apnoea syndrome (OSAS) may induce generation oxygen free radicals. Indeed, several studies suggest that OSAS is oxidative stress. present study tested hypothesis have an alteration antioxidant defences. plasma levels total status (TAS), glutathione peroxidase (GPX), gamma-glutamyltransferase (GGT), vitamins A, E, B12 and folate, homocysteine were determined 47 37 healthy...
<h3>Background:</h3> Previous studies have presented contradictory data concerning obstructive sleep apnoea syndrome (OSAS), lipid oxidation and nitric oxide (NO) bioavailability. This study was undertaken to (1) compare the concentration of 8-isoprostane total nitrate nitrite (NOx) in plasma middle-aged men with OSAS no other known co-morbidity healthy controls same age, gender body mass index; (2) test hypothesis that nasal continuous positive airway pressure (CPAP) therapy attenuates...
Excessive daytime sleepiness (EDS), obesity and insulin resistance (IR) occur frequently in patients with obstructive sleep apnoea syndrome (OSAS). We hypothesised that these patients, EDS is a marker of IR, independent obesity.We studied 44 OSAS (22 22 without EDS) matched for age (+/-5 years), body mass index (BMI +/-3 kg/m(2)) severity (as determined by the apnoea-hypopnoea (AHI)), 23 healthy controls. Patients (n = 35) were re-examined after 3 months effective therapy continuous positive...
Home respiratory polygraphy may be a simpler alternative to in-laboratory polysomnography for the management of more symptomatic patients with obstructive sleep apnea, but its effectiveness has not been evaluated across broad clinical spectrum.To compare long-term (6 mo) home and protocols in intermediate-to-high apnea suspicion (most requiring study).A multicentric, noninferiority, randomized controlled trial two open parallel arms cost-effectiveness analysis was performed 12 tertiary...
Summary The main purpose of the present analysis is to assess influence introducing early nasal continuous positive airway pressure ( nCPAP ) treatment on cardiovascular recurrences and mortality in patients with a first‐ever ischaemic stroke moderate–severe obstructive sleep apnea (OSA) an apnea–hypopnea index (AHI) ≥20 events h −1 during 5‐year follow‐up. Patients received conventional for were assigned randomly group n = 71) or control 69). Cardiovascular registered all patients. Survival...
<h3>Background</h3> Compliance with continuous positive airway pressure (CPAP) therapy is essential in patients obstructive sleep apnoea (OSA), but adequate control not always possible. This clinically important because CPAP can reverse the morbidity and mortality associated OSA. Telemedicine, support provided via a web platform video conferences, could represent cost-effective alternative to standard care management. <h3>Aim</h3> To assess telemedicine impact on treatment compliance,...
Background Hypoxic burden (HB) has emerged as a strong predictor of cardiovascular risk in obstructive sleep apnoea (OSA). We aimed to assess the potential HB predict benefit treating OSA with continuous positive airway pressure (CPAP). Methods This was post hoc analysis ISAACC trial ( ClinicalTrials.gov : NCT01335087 ) including non-sleepy patients acute coronary syndrome (ACS) diagnosed (apnoea–hypopnoea index ≥15 events·h −1 by respiratory polygraphy. Patients were randomised CPAP or...
Neuropeptide Y (NPY) and leptin are two peptides involved in the regulation of body weight, energy balance, sympathetic tone. This study investigates independent role apneas obesity on NPY plasma levels patients with obstructive sleep apnea syndrome (OSAS). To this end we compared their values 23 obese (body mass index > 30 kg/m2) 24 nonobese < 27 OSAS, 19 18 control subjects without OSAS. Patients who used continuous positive airway pressure for more than 4 hours/night were reexamined 3 12...
Obstructive sleep apnea (OSA) is an independent cause of resistant hypertension (RH) but its association with refractory (RfH), a recently described form severe hypertension, has not yet been investigated. This study seeks to analyze the between presence and severity OSA/OSA syndrome RfH compare it group patients RH. We conducted multicenter, cross-sectional consecutive diagnosed RH by means 24-hour ambulatory blood pressure monitoring. Those levels ≥130/80 mm Hg, despite taking at least 5...
Rationale: Obstructive sleep apnea (OSA) is associated with increased cardiovascular disease (CVD) risk. Conversely, OSA has not been shown to increase recurrent events in patients acute coronary syndrome (ACS). This lack of homogeneity could suggest that the deleterious effect and its contribution CVD depend on specific patient profiles.Objectives: To evaluate risk for different ACS phenotypes.Methods:Post hoc analysis ISAACC (Continuous Positive Airway Pressure Patients OSA) study,...
<i>Background:</i> Endothelial dysfunction and cardiovascular diseases are frequent in patients with obstructive sleep apnea (OSA). Circulating endothelial progenitor cells (EPCs) contribute to repair dysfunctional endothelium have been related increased risk. <i>Objectives:</i> We tested the hypothesis that number of circulating EPCs may be altered OSA patients. <i>Methods:</i> (CD34+ VEGF-R2+) were isolated quantified from peripheral blood samples (n =...