Teresa Gómez‐García
A5102860033- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Cardiovascular and Diving-Related Complications
- Cardiovascular Disease and Adiposity
- Uterine Myomas and Treatments
- Lymphatic System and Diseases
- Endometrial and Cervical Cancer Treatments
- Sleep and Wakefulness Research
- Heart Rate Variability and Autonomic Control
- Diabetes and associated disorders
- HIV-related health complications and treatments
- Alcohol Consumption and Health Effects
- HIV/AIDS drug development and treatment
- Tracheal and airway disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Cardiovascular Function and Risk Factors
- Endometriosis Research and Treatment
Hospital Universitario Fundación Jiménez Díaz
2012-2023
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2017-2023
Hospital General Universitario de Albacete
2015
<h3>Background</h3> Non-invasive ventilation (NIV) is an effective form of treatment in patients with obesity hypoventilation syndrome (OHS) who have concomitant severe obstructive sleep apnoea (OSA). However, there a paucity evidence on the efficacy NIV OHS without OSA. We performed multicentre randomised clinical trial to determine comparative versus lifestyle modification (control group) using daytime arterial carbon dioxide tension (PaCO<sub>2</sub>) as main outcome measure....
Rationale Despite a significant association between obesity hypoventilation syndrome (OHS) and cardiac dysfunction, no randomised trials have assessed the impact of non-invasive ventilation (NIV) or CPAP on structure function by echocardiography. Objectives We performed secondary analysis data from largest multicentre controlled trial OHS (Pickwick project, n=221) to determine comparative efficacy 2 months NIV (n=71), (n=80) lifestyle modification (control group, n=70) structural functional...
Rationale: Obesity hypoventilation syndrome (OHS) has been associated with cardiac dysfunction. However, randomized trials assessing the impact of long-term noninvasive ventilation (NIV) or continuous positive airway pressure (CPAP) on structure and function assessed by echocardiography are lacking.Objectives: In a prespecified secondary analysis largest multicenter controlled trial OHS (Pickwick Project; N = 221 patients coexistent severe obstructive sleep apnea), we compared effectiveness...
Noninvasive ventilation (NIV) is an effective form of treatment in obesity hypoventilation syndrome (OHS) with severe OSA. However, there paucity evidence patients OHS without OSA phenotype.Is NIV phenotype?In this multicenter, open-label parallel group clinical trial performed at 16 sites Spain, we randomly assigned 98 stable ambulatory untreated and apnea-hypopnea index < 30 events/h (ie, no OSA) to or lifestyle modification (control group) using simple randomization through electronic...
Rationale: Obstructive sleep apnea (OSA) is associated with impaired glycemic control and a higher risk of vascular complications, such as diabetic kidney disease (DKD). However, the effect apnea-hypopnea suppression on DKD progression unclear. Objectives: To assess continuous positive airway pressure (CPAP) urinary albumin-to-creatinine ratio (UACR) in patients OSA. Methods: In 52-week, multicentric, open-label, parallel, randomized clinical trial, 185 OSA were to CPAP usual care (n = 93)...
Low flow supplemental oxygen is commonly prescribed to patients with obesity hypoventilation syndrome (OHS). However, there a paucity of data regarding its efficacy and safety. The objective this study was assess the medium-term treatment adding therapy modalities in OHS.In post hoc analysis previous randomized controlled trial, we studied 302 sequentially screened OHS who were randomly assigned noninvasive ventilation, continuous positive airway pressure, or lifestyle modification. Outcomes...
Abstract Obstructive sleep apnea (OSA) is a recognized risk factor for the development of diabetic kidney disease (DKD). Our objectives were to compare urinary albumin–creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) patients with DKD according OSA severity, evaluate contribution parameters their renal function. In multicenter, observational, cross-sectional study, 214 recruited. After UACR eGFR measured, as well serum creatinine, fasting glucose, glycated hemoglobin,...
Background Obesity hypoventilation syndrome (OHS) is treated with either non-invasive ventilation (NIV) or CPAP, but there are no long-term cost-effectiveness studies comparing the two treatment modalities. Objectives We performed a large, multicentre, randomised, open-label controlled study to determine comparative cost and effectiveness of NIV versus CPAP in patients OHS severe obstructive sleep apnoea (OSA) using hospitalisation days as primary outcome measure. Methods Hospital resource...
Objective Snoring is a common reason for referral to sleep unit. Although there are several instruments measure snoring, no gold standard this purpose. In study, we determine the diagnostic accuracy of cannula as compared with microphone, which two most commonly used tools. Study Design We performed cross‐sectional study 75 patients who underwent baseline home apnea testing any reason. Methods Snore intensity and percentage were assessed during Home sleep‐apnea via nasal microphone in all...
To evaluate the long-term effectiveness, persistence and tolerability of dolutegravir (DTG)/lamivudine (3TC), compared with most frequently prescribed first-line treatment regimens, among antiretroviral-naive people HIV from CoRIS, a multicentre cohort in Spain, 2018-23.
There are no randomized controlled trials assessing the impact of noninvasive ventilation (NIV) and continuous positive airway pressure (CPAP) on cardiac function in obesity hypoventilation syndrome (OHS). <b>Objective:</b> To determine efficacy 2 months NIV, CPAP or lifestyle modification (control) echocardiographic changes. <b>Method:</b> OHS patients (n=302) were sequentially by: 1) severe obstructive sleep apnea (OSA), into control; 2) non-severe OSA, NIV control. ABG, spirometry,...
<b>Background:</b> Obesity hypoventilation syndrome (OHS) is associated with a high burden of cardiovascular morbidity (CVM) and mortality. The majority OHS patients have concomitant obstructive sleep apnea (OSA), but there paucity data on the association between CVM OSA severity in OHS. objective our study was to assess large cohort <b>Methods:</b> In cross-sectional analysis, we examined based tertiles oxygen desaturation index (ODI) 302 Logistic regression models were constructed quantify...
<b>Rationale:</b> Supplemental oxygen is commonly prescribed to patients with obesity hypoventilation syndrome (OHS). However, there paucity of data regarding its efficacy and safety. <b>Objectives:</b> To assess the medium-term treatment adding supplemental therapy modalities in OHS. <b>Methods:</b> In this post-hoc analysis a previous randomized controlled trial, we studied 302 sequentially screened OHS who were assigned positive airway pressure (PAP) or lifestyle modification. Outcomes at...
<b>Rationale:</b> Noninvasive ventilation (NIV) is an effective treatment in patients with obesity hypoventilation syndrome (OHS) who have severe obstructive sleep apnea (OSA). However, there paucity of evidence on the efficacy NIV OHS without OSA. <b>Objective:</b> We performed a multicenter randomized clinical trial to determine versus lifestyle modification (control group) using daytime PaCO<sub>2</sub> as main outcome measure. <b>Methods:</b> Sequentially screened OSA were and followed...