A5066486351- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Nonmelanoma Skin Cancer Studies
- Melanoma and MAPK Pathways
- Autoimmune Bullous Skin Diseases
- Cancer and Skin Lesions
- Nail Diseases and Treatments
- Genetic and rare skin diseases.
- melanin and skin pigmentation
- Cancer Immunotherapy and Biomarkers
- Drug-Induced Adverse Reactions
- Oral Health Pathology and Treatment
- Genital Health and Disease
- Autoimmune and Inflammatory Disorders
- Cell Image Analysis Techniques
- Herpesvirus Infections and Treatments
- Skin and Cellular Biology Research
- Colorectal Cancer Treatments and Studies
- Optical Coherence Tomography Applications
- Chemotherapy-related skin toxicity
- Contact Dermatitis and Allergies
- Cancer Treatment and Pharmacology
- Infectious Diseases and Mycology
- Eosinophilic Disorders and Syndromes
- Body Contouring and Surgery
Parc de Salut
2015-2025
Universitat Pompeu Fabra
2022-2025
Hospital del Mar Research Institute
2015-2024
Universitat Autònoma de Barcelona
2009-2024
Hospital Del Mar
2009-2024
Universitat de Vic - Universitat Central de Catalunya
2023
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2023
Centre Hospitalier Universitaire de Nantes
2016-2017
Hospital Clínic de Barcelona
2006-2009
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2004-2008
Purpose Primary care physicians (PCPs) constitute an appropriate target for new interventions and educational campaigns designed to increase skin cancer screening prevention. The aim of this randomized study was determine whether the adjunct dermoscopy standard clinical examination improves accuracy PCPs triage lesions suggestive cancer. Patients Methods in Barcelona, Spain, Naples, Italy, were given a 1-day training course detection dermoscopic evaluation, randomly assigned evaluation arm...
<h3>Objectives</h3> To identify in vivo microscopic substrates of the dermoscopic patterns melanocytic lesions and to correlate them with histopathologic features. <h3>Design</h3> Before excision, lesion areas that showed characteristic were imaged by dermoscopy confocal microscopy directly correlated <h3>Setting</h3> Departments Dermatology University Modena Reggio Emilia Hospital Clínico Barcelona, between July 2006 March 2007. <h3>Patients</h3> Patients 202 lesions, corresponding 76...
Intralymphatic histiocytosis is a rare condition characterized by the presence of dilated lymphatic vessels containing aggregates mononuclear histiocytes (macrophages) within their lumina. The phenomenon seems to occur almost exclusively reticular dermis. Although its pathogenesis remains uncertain, there has been speculation about possible relationship between intralymphatic and intravascular reactive angioendotheliomatosis. In addition, several examples historically have associated with...
Objective: To characterize nodular melanoma (NM) using dermoscopy, in vivo reflectance-mode confocal microscopy, and histopathologic analysis.Design: Consecutive pure NMs superficial spreading melanomas (SSMs) with or blue areas were studied dermoscopy a correlation findings was performed.Materials: Ten NMs, 10 SSMs area, palpable but not yet area.
Abstract Dermatofibrosarcoma protuberans (DFSP) is characterized by the presence of t(17;22)(q22;q13) that leads to fusion COL1A1 and PDGFB genes. This translocation can be detected multiplex reverse transcriptase‐polymerase chain reaction (RT‐PCR) or fluorescence in situ hybridization (FISH) techniques. We have evaluated usefulness a dual color FISH probe strategy for COL1A1/PDGFB detection series 103 archival DFSPs compared obtained results with RT‐PCR analyses. were carried out on...
Melanomas that clinically mimic seborrheic keratosis (SK) can delay diagnosis and adequate treatment. However, little is known about the value of dermoscopy in recognizing these difficult-to-diagnose melanomas.To describe dermoscopic features SK-like melanomas to understand their clinical morphology.This observational retrospective study used 134 images histopathologically proven patients treated 9 skin cancer centers Spain, France, Italy, Austria. Without knowledge definite for all lesions...
Cutaneous immune-related adverse events (irAEs) represent the most frequent toxicities induced by immune checkpoint inhibitors (ICIs).To investigate clinical associations of cutaneous different ICI therapies.This was a multicentre retrospective international cohort study patients with cancer who developed irAEs under therapy. Analysis performed rates and basic characteristics all toxicities, identification any using univariate multivariate models.In total, 762 were included, 993 toxicities....
<h3>Background</h3> Reflectance-mode confocal microscopy (RCM) is a new approach for the in vivo diagnosis of skin tumors. A few studies RCM on basal cell carcinoma (BCC) have provided specific diagnostic criteria, but large pigmented are lacking. Proliferation dendritic-shaped cells within melanocytic tumor has been associated with melanoma by RCM. Benign melanocytes and Langerhans may populate BCC according to previous histological studies. We studied 3 consecutive means performed...
Nonsurgical treatment (radiotherapy, imiquimod) is increasingly employed for the management of lentigo maligna (LM). While diagnosis LM remains difficult, detection failure even more challenging.To describe sensitivity and specificity individual features methods using dermoscopy in vivo reflectance confocal microscopy (RCM) to aid following nonsurgical treatment.A retrospective study RCM images (blinded correlation with pathology) patients biopsy-confirmed who were undergoing two referral...
Amino acid homology searches of the human genome revealed three members metallocarboxypeptidase (metallo-CP) family that had not been described in literature addition to 14 known genes. One these three, named <i>CPA5</i>, is present a gene cluster with <i>CPA1</i>, <i>CPA2</i>, and <i>CPA4</i>on chromosome 7. The cDNA encoding mouse homolog human<i>CPA5</i> was isolated from testis library sequenced. deduced amino sequence CPA5 has highest identity (60%) CPA1. Modeling analysis shows overall...
The objective of the study was to analyse prevalence and clinical significance hypocomplementemia in a large series patients diagnosed either with systemic lupus erythematosus (SLE) or primary antiphospholipid syndrome (APS) its association main clinical, hematological immunological features these diseases. Between 1992 2003, complement determinations (C3 C4 levels, CH50 activity) were performed 597 consecutive SLE (530 women 67 men, mean age 32.6 years) 70 APS (57 13 38.7) visited our...
Journal Article Eosinophilic ulcer of the oral mucosa: another histological simulator CD30+ lymphoproliferative disorders Get access S. Segura, Segura Departments Dermatology and Pathology, Hospital Clínic, University Barcelona, 170 Villarroel, 08036 Spain Sonia Segura. E‐mail: sonietast@yahoo.es Search for other works by this author on: Oxford Academic Google Scholar D. Romero, Romero J.M. Mascaró, Jr, Jr L. Colomo, Colomo J. Ferrando, Ferrando T. Estrach British Dermatology, Volume 155,...
Eosinophilic ulcer of the oral mucosa (EUOM) is an uncommon self‐limited condition that clinically manifests as a solitary ulceration with elevated indurate borders affecting tongue, buccal or lip. Microscopically, it characterized by polymorphic inflammatory infiltrate prominent polymorphonuclear eosinophilic component extending deep into submucosa, underlying muscle and salivary glands. Large mononuclear cells probably corresponding to histiocytes, myofibroblasts activated lymphoid are...
Nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy is a rare fibrotic condition that presents in patients with history of renal disease. The aetiology unknown, but it has recently been proposed gadolinium, paramagnetic contrast agent, may be trigger this We report three NSF use gadolinium magnetic resonance angiography few weeks before the onset symptoms. In future, should probably avoided as much possible insufficiency until its role development clarified.
The introduction of cyclin-dependent kinase inhibitors (CDK4/6i) was a great advance in therapeutics for patients with estrogen receptor+/human epidermal growth factor receptor (HER2) locally advanced and metastatic breast cancer. Despite the increasing use these agents, their adverse drug-related events have not yet been fully characterized. We describe spectrum cutaneous reactions occurring cancer treated inhibitors, analyzing types, severity, time to onset, possible treatment outcomes.We...
Abstract Background Patients with genodermatosis such as Gorlin syndrome (GS) and Xeroderma pigmentosum (XP) require a close follow‐up for early diagnosis treatment of skin cancer. We aimed to evaluate the efficacy methyl‐aminolevulinate (MAL) photodynamic therapy (PDT) in basal cell carcinomas (BCCs) from patients GS XP, determine utility reflectance confocal microscopy (RCM) evaluation therapeutic response. methods included four two siblings XP. Single or multiple lesions localized areas...
<h3>Background</h3> Exogenous ochronosis presents as an acquired asymptomatic hyperpigmentation on photoexposed areas, predominantly over bony prominences, and is caused by the topical application of several skin-lightening agents. <h3>Observations</h3> We describe a 63-year-old Hispanic woman who developed exogenous lesions her face after using bleaching creams containing hydroquinone, 2% to 3%, oxybenzone, 2%, for years. Dermoscopy revealed irregular brown-gray globular, annular, arciform...
Early stages of 36 melanomas on limbs were morphologically characterised. Most occurred in high-risk patients (multiple and/or familial melanoma) attending a referral unit for melanoma and pigmented lesions. None the tumours was clinically suspicious (mean diameter 4.3 mm). The classified into four dermoscopic groups: (i) prominent network (n=16); (ii) delicate (n=5); (iii) hypo-pigmentation with dotted vessels (n=10); (iv) diffuse light pigmentation perifollicular (n=5). Confocal microscopy...
Malignant melanomas mimicking seborrheic keratosis (SK-like MMs) carry the risk of delayed diagnosis and inadequate treatment. The value dermoscopy to improve correct detection these mimickers has not been previously studied.To evaluate diagnostic accuracy clinically SK-like MMs with without dermoscopy.Clinical dermoscopic images histopathologically proven (n = 134) intermingled other benign tumors were randomly presented clinicians different levels experience, blinded goal study. Each...