A5102897607- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Autoimmune and Inflammatory Disorders
- Platelet Disorders and Treatments
- Mycobacterium research and diagnosis
- Biomedical Research and Pathophysiology
- Nail Diseases and Treatments
- Inflammasome and immune disorders
- HIV-related health complications and treatments
- Eosinophilic Disorders and Syndromes
- Musculoskeletal synovial abnormalities and treatments
- Soft tissue tumors and treatment
- HIV Research and Treatment
- Infectious Diseases and Mycology
- Dysphagia Assessment and Management
- Immunodeficiency and Autoimmune Disorders
- Skin and Cellular Biology Research
- Nerve Injury and Rehabilitation
- Hair Growth and Disorders
- Hepatitis Viruses Studies and Epidemiology
- Facial Rejuvenation and Surgery Techniques
- Tuberous Sclerosis Complex Research
- Inflammatory Myopathies and Dermatomyositis
- Transgenic Plants and Applications
Hospital Clínic de Barcelona
2012-2025
Universitat de Barcelona
2006-2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2004-2010
Barcelona Biomedical Research Park
2010
Dipeptidyl peptidase-4 (DPP-4) inhibitors have increasingly been identified as causative agents of bullous pemphigoid. The clinical and immunological characteristics this pemphigoid variant are still unclear. objective our study was to analyze the features patients with induced by DPP-4 inhibitors.All diagnosed inhibitor-associated at dermatology departments in three Spanish centers during period 2013 2015 were included. ELISA assays for NC16A domain BP180 BP230 performed. Immunoblot studies...
Epidermolysis bullosa acquisita is an exceedingly rare subepidermal blistering disease caused by antibodies against type VII collagen. Studies summarizing the clinical and immunological features of this in large series patients are scarce.To analyse immunopathological characteristics, treatment responses outcomes 12 with epidermolysis from four tertiary hospitals Spain.An extensive retrospective review charts.The mean age onset was 48 years delay to diagnosis 20·75 months. The classical...
Facial discoid dermatosis (FDD) is a condition characterized by papules-plaques primarily affecting the face. FDD has been associated with psoriasis, seborrheic dermatitis, and pityriasis rubra pilaris. We conducted retrospective multicenter study 13 patients diagnosed in Spain (2014-2022). Patient demographics, clinical presentations, histopathological findings, treatment outcomes were collected. shows as erythematous-orange, nummular papules and/or plaques dry scales that affect facial...
There has been no previous clinical-immunological study of pemphigus in Spain. The aim this was to perform a retrospective analysis patients who had followed for period 18 years our centre. We characterized the autoantibody response, compared diagnostic assays and correlated immunobiological data with phenotype prognosis. Clinical, epidemiological immunopathological were collected from 40 patients. Patients sera by indirect immunofluorescence enzyme-linked immunosorbent assay (ELISA)....
Bullous pemphigoid (BP) is an autoimmune subepidermal bullous disease in which autoantibodies are directed against components of the basement membrane. Most these antibodies belong to immunoglobulin G class and bind principally 2 hemidesmosomal proteins: 180-kD antigen (BP180) 230-kD (BP230). It most common blistering adult population developed countries, with estimated incidence Spain 0.2 3 cases per 100,000 inhabitants year. The primarily affects older people, although it can also occur...
Pyodermatitis-pyostomatitis vegetans is a rare mucocutaneous dermatosis often associated with gastrointestinal disorders, especially inflammatory bowel disease. It clinically characterized by erythematous lesions multiple pustules and erosions affecting the mucosal surfaces. Cutaneous are exudative vegetating plaques frequently axillae groins. The clinical diagnosis supported histologic findings, whereas immunofluorescence studies useful to rule out other entities such as pemphigus3. Herein...
Paraneoplastic pemphigus is a life-threatening autoimmune bullous disease associated with neoplasia, generally of lymphoid origin. Immunosuppressive therapy often disappointing and there are only few reports patients surviving more than 2 years. These cases were benign neoplasms. We report here the case patient paraneoplastic non-Hodgkin B-cell lymphoma who had surprisingly good response to systemic corticosteroids remains free lesions 3 years later despite progression her neoplasm.
Summary Background and objectives Ocular/periocular involvement in pemphigus vulgaris (OPV) has rarely been reported. The objective of the present study was to investigate pattern OPV define prognostic value its manifestation. Patients methods From 1985 2014, a total 167 patients with (PV) were treated at four tertiary Spanish hospitals. In this retrospective study, we included all OPV. Clinical data information on associated symptoms obtained from patients’ medical records. Results Only 24...
The mainstay of treatment for pemphigus is systemic corticosteroids. Different adjuvants have been used to reduce side-effects long-term corticotherapy. Gold an anti-inflammatory drug in autoimmune diseases, whose use has waned with the advent new immunosuppressive agents.To study outcome intramuscular gold vulgaris refractory previous therapies.Thirteen patients who had failed respond several prior therapies were treated aurothiomalate, as a steroid-sparing agent. Patients monitored assess...
Abstract We describe a patient with nonclassical clinical and histopathological features of pemphigus exclusively IgG antibodies against desmocollin (Dsc) 3 detected by enzyme‐linked immunosorbent assay recombinant eukaryotic protein Dsc1‐Dsc3. The absence other known targets, such as desmogleins, reinforces the role anti‐Dsc in pathophysiology atypical pemphigus.
The case of a bisexual male patient with acquired immunodeficiency syndrome (AIDS) and an infected abdominal aortic aneurysm requiring surgery is presented. Attention drawn to the fact that unpredictable number operations will be needed in AIDS patients next future.
Background: The diagnosis of pemphigus vulgaris and foliaceus is usually based on clinical, histological, immunofluorescence (IF) findings. In recent years, the antigenic profile both diseases has been further defined by immunobiochemical techniques (ELISA, immunoblot, immunoprecipitation). Methods: A retrospective study 40 patients was performed to determine in with followed at our Department. Charts review, clinical data, histological IF findings, analysis ELISA were all patients. Results:...
Lichen planus pemphigoides (LPP) is a rare autoimmune subepidermal blistering disease characterized by the coexistence of both lichen and either bullous pemphigoid or mucous membrane (MMP) features. Frontal fibrosing alopecia (FFA) scarring alopecia, generally considered form planopilaris. We report two patients with concomitant FFA MPP. Patient 1 was 73-year-old woman clinical histological diagnosis oral planus. In addition, she presented alopecic plaques in parietal area blisters,...
Monoallelic NLRC4 gain-of-function variants cause an inflammasomopathy with diverse clinical forms including infantile enterocolitis, recurrent macrophage activation syndrome, cold-induced urticaria-like lesions (or familial-cold autoinflammatory FCAS4), and painful subcutaneous nodules. Here, we identified a large family six consecutive generations affected. Genetic analyses detected the heterozygous p.Ser445Pro variant in three patients, which has been previously reported Dutch FCAS4. We...