A5037938709- Obstructive Sleep Apnea Research
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and Diving-Related Complications
- Cardiac Arrest and Resuscitation
- Sleep and related disorders
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Cardiovascular Disease and Adiposity
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Gastrointestinal disorders and treatments
- Head and Neck Cancer Studies
- COVID-19 Clinical Research Studies
- Labor Law and Work Dynamics
- Acute Ischemic Stroke Management
- Congenital Heart Disease Studies
- Airway Management and Intubation Techniques
- Celiac Disease Research and Management
- Gastroesophageal reflux and treatments
- Sleep and Wakefulness Research
Marqués de Valdecilla University Hospital
2016-2025
Hospital Clínico de la Universidad de Chile
2023-2025
Instituto de Investigación Marqués de Valdecilla
2018-2025
Universidad de Cantabria
2002-2025
Hospital Roberto del Rio
2015-2025
University of Chicago
2025
The University of Texas Southwestern Medical Center
2025
Southwestern Medical Center
2025
Centro Científico Tecnológico - Nordeste
2024
Cuban Neuroscience Center
2023
Continuous positive airway pressure (CPAP) is the first-line treatment for patients with symptomatic obstructive sleep apnea (OSA). However, its indication all sleep-disordered breathing, regardless of daytime symptoms, unclear.To evaluate effect CPAP on incidence hypertension or cardiovascular events in a cohort nonsleepy OSA.Multicenter, parallel-group, randomized controlled trial 14 teaching hospitals Spain. Between May 2004 and 2006, 725 consecutive were enrolled who had an...
for the Spanish
Rationale: Continuous positive airway pressure (CPAP) is the current treatment for patients with symptomatic obstructive sleep apnea (OSA). Its use all subjects sleep-disordered breathing, regardless of daytime symptoms, unclear.Objectives: This multicenter controlled trial assesses effects 1 year CPAP on blood (BP) in nonsymptomatic, hypertensive OSA.Methods: We evaluated 359 OSA. Inclusion criteria consisted an apnea–hypopnea index (AHI) greater than 19 hour−1, Epworth Sleepiness Scale...
Barbé, Ferran*†; Durán-Cantolla, Joaquín†‡; Sánchez de la Torre, Manuel*†; Martínez-Alonso, Montserrat*; Carmona, Carmen§; Barceló, Antonia†∥; Chiner, Eusebi¶; Masa, Juan F.#†; Gonzalez, Mónica**†††; Marín, Jose M.†††; Garcia-Rio, Francisco‡‡; Atauri, Josefa Diaz**; Terán, Joaquín†§§; Mayos, Mercedes†∥∥; Peña, Mónica†¶; Monasterio, Carmen†¶¶; del Campo, Felix##; Montserrat, Josep M.†*** for the Spanish Sleep and Breathing Network Author Information
Obstructive sleep apnea (OSA) has been associated with increased cancer mortality, but whether it is also incidence unknown.To investigate OSA in a large clinical cohort.A multicenter, cohort study including consecutive patients investigated for suspected between 2003 and 2007 seven Spanish teaching hospitals. Apnea-hypopnea index (AHI) percent nighttime oxygen saturation less than 90% (TSat(90)) were used as surrogates of severity, both continuous variables categorized by tertiles. Cox...
The incidence of obesity hypoventilation syndrome (OHS) may be increasing in parallel with the present epidemic. Despite extensive noninvasive ventilation (NIV) and continuous positive airway pressure (CPAP) use patients OHS, information regarding efficacy is limited.We performed a large, multicenter randomized controlled study to determine comparative NIV, CPAP, lifestyle modification (control group) using daytime PaCO2 as main outcome measure.Sequentially screened OHS severe sleep apnea...
To assess the effect of continuous positive airway pressure (CPAP) on 24 hour ambulatory blood monitoring values in a large number patients with untreated systemic hypertension new onset and obstructive sleep apnoea.Multicentre, double blind, randomised, placebo controlled trial.Eleven general hospitals Spain between 2004 2007.340 recently diagnosed as having by practitioner (systolic ≥140 mm Hg, diastolic ≥90 or both) an apnoea-hypopnoea index per >15 events/hour.Patients were assigned to...
Introduction:Obesity in children is assumed to serve as a major risk factor pediatric obstructive sleep apnea syndrome (OSAS). However, the prevalence of OSAS otherwise healthy obese from community unknown.
<h3>Background</h3> Non-invasive ventilation (NIV) is an effective form of treatment in patients with obesity hypoventilation syndrome (OHS) who have concomitant severe obstructive sleep apnoea (OSA). However, there a paucity evidence on the efficacy NIV OHS without OSA. We performed multicentre randomised clinical trial to determine comparative versus lifestyle modification (control group) using daytime arterial carbon dioxide tension (PaCO<sub>2</sub>) as main outcome measure....
Introduction. Obesity and obstructive sleep apnea syndrome (OSA) are common coexisting conditions associated with a chronic low-grade inflammatory state underlying some of the cognitive, metabolic, cardiovascular morbidities. Aim. To examine levels markers in obese community-dwelling children OSA, as compared to no-OSA, their association clinical polysomnographic (PSG) variables. Methods. In this cross-sectional, prospective multicenter study, healthy Spanish (ages 4–15 years) were randomly...
Rationale Despite a significant association between obesity hypoventilation syndrome (OHS) and cardiac dysfunction, no randomised trials have assessed the impact of non-invasive ventilation (NIV) or CPAP on structure function by echocardiography. Objectives We performed secondary analysis data from largest multicentre controlled trial OHS (Pickwick project, n=221) to determine comparative efficacy 2 months NIV (n=71), (n=80) lifestyle modification (control group, n=70) structural functional...
Obstructive sleep apnea (OSA) is an independent cause of resistant hypertension (RH) but its association with refractory (RfH), a recently described form severe hypertension, has not yet been investigated. This study seeks to analyze the between presence and severity OSA/OSA syndrome RfH compare it group patients RH. We conducted multicenter, cross-sectional consecutive diagnosed RH by means 24-hour ambulatory blood pressure monitoring. Those levels ≥130/80 mm Hg, despite taking at least 5...
Objectives: To describe the deployment of pediatric Calculated Assessment Risk and Triage (pCART), a machine learning (ML) model to predict risk direct ward ICU transfer within 12 hours, associated improved outcomes among hospitalized children. Design: Pre- vs. post-implementation study. Setting: An urban, tertiary-care, academic hospital. Patients: Pediatric (age < 18 yr) admissions from May 1, 2019, April 30, 2023. Interventions: None. Measurements Main Results: Patients were divided...
Rationale: Obesity hypoventilation syndrome (OHS) has been associated with cardiac dysfunction. However, randomized trials assessing the impact of long-term noninvasive ventilation (NIV) or continuous positive airway pressure (CPAP) on structure and function assessed by echocardiography are lacking.Objectives: In a prespecified secondary analysis largest multicenter controlled trial OHS (Pickwick Project; N = 221 patients coexistent severe obstructive sleep apnea), we compared effectiveness...
The first line of treatment obstructive sleep apnoea syndrome (OSAS) in children consists adenotonsillectomy (T&A). aim the present study was to evaluate outcomes OSAS among obese recruited from community. A cross-sectional, prospective, multicentre Spanish aged 3–14 years, with four groups available for follow-up: group 1: non-OSAS no treatment; 2: dietary 3: surgical and 4: continuous positive airway pressure treatment. 117 (60 boys, 57 girls) a mean age 11.3±2.9 years completed...
Home single-channel nasal pressure (HNP) may be an alternative to polysomnography (PSG) for obstructive sleep apnea (OSA) diagnosis, but no cost studies have yet been carried out. Automatic scoring is simpler generally less effective than manual scoring.To determine the diagnostic efficacy and of both scorings (automatic manual) compared with PSG, taking as a polysomnographic OSA diagnosis several apnea-hypopnea index (AHI) cutoff points.We included suspected patients in multicenter study....